Nasolacrimal drainage system implants for drug therapy
First Claim
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1. A drug insert configured for placement within a channel of a punctal plug, comprising:
- a drug core comprising a therapeutic agent admixed with a polymer matrix comprising a non-bioabsorbable polymer;
an impermeable sheath body partially covering the drug core, wherein the sheath body is configured to provide an exposed proximal end of the drug core in direct contact with tear fluid that releases therapeutic agent to the eye when the drug insert is disposed within a channel of the punctal plug and the punctal plug is inserted into a lacrimal canaliculus of a subject; and
,a sealant covering a distal end of the drug insert.
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Abstract
An implant for insertion through a punctum and into a canalicular lumen of a patient. The implant includes a matrix of material, a therapeutic agent dispersed in the matrix of material, a sheath disposed over a portion of the matrix of material and configured to inhibit the therapeutic agent from being released from the matrix of material into the canalicular lumen and to allow the therapeutic agent to be released from a surface of the matrix of material to a tear film, and a retention structure configured to retain the implant within the canalicular lumen.
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Citations
8 Claims
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1. A drug insert configured for placement within a channel of a punctal plug, comprising:
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a drug core comprising a therapeutic agent admixed with a polymer matrix comprising a non-bioabsorbable polymer; an impermeable sheath body partially covering the drug core, wherein the sheath body is configured to provide an exposed proximal end of the drug core in direct contact with tear fluid that releases therapeutic agent to the eye when the drug insert is disposed within a channel of the punctal plug and the punctal plug is inserted into a lacrimal canaliculus of a subject; and
,a sealant covering a distal end of the drug insert. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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Specification