Microarray for delivery of therapeutic agent and methods of use
First Claim
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1. A microstructure apparatus, comprising:
- an approximately planar substrate having a first surface and a second surface opposed thereto; and
a microstructure array comprising a plurality of microstructures contacting the first surface of the substrate and fixedly attached thereto, at least a distal end of the microstructures being formed of a polymer matrix comprising at least one of;
(a) a formulation comprising;
(i) at least one low molecular weight polymer having a molecular weight of between about 1-10K Da,(ii) at least one high molecular weight polymer having a molecular weight of between about 50-300K Da, where the ratio of low molecular weight polymer to high molecular weight polymer is about 4;
1, and(iii) at least one therapeutic agent;
or(b) a formulation comprising;
(i′
) at least one water-insoluble biodegradable polymer,(ii′
) a hydrophilic component at about 10-20% of the polymer matrix, and(iii′
) at least one therapeutic agent; and
wherein the polymer matrix is prepared by a process comprising dissolving the at least one therapeutic agent in a polymer solution and dispensing the polymer solution on a mold having an array of microstructure cavities, whereby the therapeutic homogenously in the polymer matrix forming the at least distal end of the microstructures;
wherein the polymer matrix is composed to thereby release the therapeutic agent from the polymer matrix sustained for a period of time, the period of time having a minimum duration of about 1 hour; and
wherein the polymer matrix is composed to release the therapeutic agent from the polymer matrix at an initial release rate of about 0.05-10%/minute.
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Abstract
Microstructure arrays and methods for using and manufacturing the arrays are described.
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Citations
31 Claims
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1. A microstructure apparatus, comprising:
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an approximately planar substrate having a first surface and a second surface opposed thereto; and a microstructure array comprising a plurality of microstructures contacting the first surface of the substrate and fixedly attached thereto, at least a distal end of the microstructures being formed of a polymer matrix comprising at least one of; (a) a formulation comprising; (i) at least one low molecular weight polymer having a molecular weight of between about 1-10K Da, (ii) at least one high molecular weight polymer having a molecular weight of between about 50-300K Da, where the ratio of low molecular weight polymer to high molecular weight polymer is about 4;
1, and(iii) at least one therapeutic agent;
or(b) a formulation comprising; (i′
) at least one water-insoluble biodegradable polymer,(ii′
) a hydrophilic component at about 10-20% of the polymer matrix, and(iii′
) at least one therapeutic agent; andwherein the polymer matrix is prepared by a process comprising dissolving the at least one therapeutic agent in a polymer solution and dispensing the polymer solution on a mold having an array of microstructure cavities, whereby the therapeutic homogenously in the polymer matrix forming the at least distal end of the microstructures; wherein the polymer matrix is composed to thereby release the therapeutic agent from the polymer matrix sustained for a period of time, the period of time having a minimum duration of about 1 hour; and wherein the polymer matrix is composed to release the therapeutic agent from the polymer matrix at an initial release rate of about 0.05-10%/minute. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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Specification