Drug delivery device and methods having an occluding member

• US 10,384,048 B2
• Filed: 08/29/2017
• Issued: 08/20/2019
• Est. Priority Date: 07/25/2014
• Status: Active Grant

• Current Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Original Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Inventors: Clay, Danielle L., Snyder, Lloyd, Soucia, Jeffrey A., Merves, Michael, Belton, Antonio, Corrigan, Sean, Grider, Keith, Lau, Michael Honsing, Leatzow, Derek
• Primary Examiner(s): Eisenberg, Rebecca E
• Application Number:
  US15/689,810
• Publication Number:
  US 20170354811A1
• Time in Patent Office: 721 Days
• CPC Class Codes: A61M 2205/32 with radio-opaque indicia
• CPC Class Codes: A61M 2205/584 having a color code
• CPC Class Codes: A61M 2205/60 with identification means
• CPC Class Codes: A61M 2207/10 Device therefor
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: A61M 5/31576 Constructional features or modes of drive mechanisms for piston rods

Abstract

Drug depot delivery devices and methods for delivering a drug depot to a site beneath the skin of a patient are provided. In various embodiments the device has a housing having a top housing end, and a bottom housing end. The housing defines a housing channel. The device has a drug cartridge defining a depot channel aligned with the housing channel and configured to slidably accept the drug depot. The drug cartridge has at least a first occluding device configured to occlude the depot channel at a first position such that the drug depot cannot pass through the depot channel without force applied to the drug depot sufficient to deflect the first occluding device. The bottom end of the housing has a coupling configuration for engaging a cannula. A plunger has a push rod to expel the drug depot through the occluding device and the cannula.

Claims

1. A drug delivery device comprising:

a housing comprising a first channel and a second channel that is in communication with the first channel; and

a drug cartridge removably positioned in the first channel, the drug cartridge comprising a first cantilever arm and a second cantilever arm, the cantilever arms defining a passageway that is aligned with the second channel, the passageway having a drug depot positioned therein,

wherein the drug cartridge comprises a first plate and a second plate that is coupled to the first plate, the first plate comprising the first cantilever arm and the second plate comprising the second cantilever arm,

wherein the first plate comprises a plurality of spaced apart bosses that are each positioned in a receiving hole in the second plate to couple the second plate to the first plate.

2. A drug delivery device as recited in claim 1, wherein the cantilever arms are each configured to occlude the passageway at an occluding position such that the drug depot cannot pass through the passageway at the occluding positions without force, greater than that of gravity, applied to the drug depot sufficient to deflect one of the cantilever arms an amount permitting passage of the drug depot past one of the cantilever arms.

3. A drug delivery device as recited in claim 1, wherein the first cantilever arm comprises a first protrusion and the second cantilever arm comprises a second protrusion, the drug depot being positioned between the first protrusion and the second protrusion.

4. A drug delivery device as recited in claim 1, wherein the first cantilever arm comprises a first ramped protrusion and the second cantilever arm comprises a second ramped protrusion, the drug depot being positioned between the first ramped protrusion and the second ramped protrusion.

5. A drug delivery device as recited in claim 1, wherein the first cantilever arm comprises a first ramped protrusion and the second cantilever arm comprises a second ramped protrusion, the drug depot being positioned between the first ramped protrusion and the second ramped protrusion, the plates each comprising a half channel extending from an end of a respective plate along a body of the respective plate and a corresponding one of the cantilever arms up to a corresponding one of the ramped protrusions, the half channels being aligned together to define the passageway.

6. A drug delivery device as recited in claim 1, further comprising a funnel body coupled to the housing such that the drug cartridge is positioned between the funnel body and the second channel, the funnel body comprising a tapered funnel bore and a tubular bore that is in communication with the passageway.

7. A drug delivery device as recited in claim 6, wherein the funnel body includes a pair of flanges that are each received in a slot in the housing to prevent the funnel body from rotating relative to the housing.

8. A drug delivery device as recited in claim 6, further comprising a plunger, the plunger comprising a knob and a push rod, the knob including a tapered portion configured for disposal in the tapered funnel bore such that the push rod extends through the tubular bore, the channels and the passageway.

9. A drug delivery device as recited in claim 1, further comprising a cannula that is coupled to the housing such that a lumen of the cannula is in communication with the second channel.

10. A drug delivery device as recited in claim 1, wherein the drug cartridge comprises a clear material and the housing comprising a viewing aperture such that the drug depot is viewable through the viewing aperture.

11. A drug delivery device comprising:

a housing comprising a first channel and a second channel that is in communication with the first channel;

a drug cartridge removably positioned in the first channel, the drug cartridge comprising a first plate including a first cantilever arm and a second plate including a second cantilever arm, the cantilever arms defining a passageway that is aligned with the second channel, the passageway having a drug depot positioned therein; and

a push rod configured to be positioned through the channels and the passageway to apply a force to the drug depot sufficient to deflect at least one of the cantilever arms to expel the drug depot from the passageway,

wherein the first plate comprises a plurality of spaced apart bosses that are each positioned in a receiving hole in the second plate to couple the second plate to the first plate.

12. A drug delivery device as recited in claim 11, wherein the cantilever arms are each configured to occlude the passageway at an occluding position such that the drug depot cannot pass through the passageway at the occluding positions without force, greater than that of gravity, applied to the drug depot sufficient to deflect one of the cantilever arms an amount permitting passage of the drug depot past one of the cantilever arms.

13. A drug delivery device as recited in claim 11, wherein the first cantilever arm comprises a first ramped protrusion and the second cantilever arm comprises a second ramped protrusion, the drug depot being positioned between the first ramped protrusion and the second ramped protrusion.

14. A drug delivery device as recited in claim 11, wherein the first cantilever arm comprises a first ramped protrusion and the second cantilever arm comprises a second ramped protrusion, the drug depot being positioned between the first ramped protrusion and the second ramped protrusion, the plates each comprising a half channel extending from an end of a respective plate along a body of the respective plate and a corresponding one of the cantilever arms up to a corresponding one of the ramped protrusions, the half channels being aligned together to define the passageway.

15. A drug delivery device as recited in claim 11, further comprising a funnel body coupled to the housing such that the drug cartridge is positioned between the funnel body and the second channel, the funnel body comprising a tapered funnel bore and a tubular bore that is in communication with the passageway.

16. A drug delivery device as recited in claim 15, wherein the push rod includes a knob having a tapered portion configured for disposal in the tapered funnel bore such that the push rod extends through the tubular bore, the channels and the passageway.

17. A drug delivery device comprising:

a housing comprising a first channel and a second channel that is in communication with the first channel; and

a drug cartridge removably positioned in the first channel, the drug cartridge comprising a first cantilever arm and a second cantilever arm, the cantilever arms defining a passageway that is aligned with the second channel, the passageway having a drug depot positioned therein,

wherein the drug cartridge comprises a first plate and a second plate that is coupled to the first plate, the first plate comprising the first cantilever arm and the second plate comprising the second cantilever arm,

wherein the first cantilever arm comprises a first ramped protrusion and the second cantilever arm comprises a second ramped protrusion, the drug depot being positioned between the first ramped protrusion and the second ramped protrusion, the plates each comprising a half channel extending from an end of a respective plate along a body of the respective plate and a corresponding one of the cantilever arms up to a corresponding one of the ramped protrusions, the half channels being aligned together to define the passageway.

18. A drug delivery device as recited in claim 17, wherein the cantilever arms are each configured to occlude the passageway at an occluding position such that the drug depot cannot pass through the passageway at the occluding positions without force, greater than that of gravity, applied to the drug depot sufficient to deflect one of the cantilever arms an amount permitting passage of the drug depot past one of the cantilever arms.

19. A drug delivery device as recited in claim 17, wherein the first cantilever arm comprises a first protrusion and the second cantilever arm comprises a second protrusion, the drug depot being positioned between the first protrusion and the second protrusion.

20. A drug delivery device as recited in claim 17, wherein the first cantilever arm comprises a first ramped protrusion and the second cantilever arm comprises a second ramped protrusion, the drug depot being positioned between the first ramped protrusion and the second ramped protrusion.

21. A drug delivery device as recited in claim 17, further comprising a funnel body coupled to the housing such that the drug cartridge is positioned between the funnel body and the second channel, the funnel body comprising a tapered funnel bore and a tubular bore that is in communication with the passageway.

22. A drug delivery device as recited in claim 21, wherein the funnel body includes a pair of flanges that are each received in a slot in the housing to prevent the funnel body from rotating relative to the housing.

23. A drug delivery device as recited in claim 21, further comprising a plunger, the plunger comprising a knob and a push rod, the knob including a tapered portion configured for disposal in the tapered funnel bore such that the push rod extends through the tubular bore, the channels and the passageway.

24. A drug delivery device as recited in claim 17, further comprising a cannula that is coupled to the housing such that a lumen of the cannula is in communication with the second channel.

25. A drug delivery device as recited in claim 17, wherein the drug cartridge comprises a clear material and the housing comprising a viewing aperture such that the drug depot is viewable through the viewing aperture.

26. A drug delivery device comprising:

a housing comprising a first channel and a second channel that is in communication with the first channel;

a drug cartridge removably positioned in the first channel, the drug cartridge comprising a first cantilever arm and a second cantilever arm, the cantilever arms defining a passageway that is aligned with the second channel, the passageway having a drug depot positioned therein; and

a funnel body coupled to the housing such that the drug cartridge is positioned between the funnel body and the second channel, the funnel body comprising a tapered funnel bore and a tubular bore that is in communication with the passageway, wherein the funnel body includes a pair of flanges that are each received in a slot in the housing to prevent the funnel body from rotating relative to the housing.

27. A drug delivery device as recited in claim 26, wherein the cantilever arms are each configured to occlude the passageway at an occluding position such that the drug depot cannot pass through the passageway at the occluding positions without force, greater than that of gravity, applied to the drug depot sufficient to deflect one of the cantilever arms an amount permitting passage of the drug depot past one of the cantilever arms.

28. A drug delivery device as recited in claim 26, wherein the first cantilever arm comprises a first protrusion and the second cantilever arm comprises a second protrusion, the drug depot being positioned between the first protrusion and the second protrusion.

29. A drug delivery device as recited in claim 26, wherein the first cantilever arm comprises a first ramped protrusion and the second cantilever arm comprises a second ramped protrusion, the drug depot being positioned between the first ramped protrusion and the second ramped protrusion.

30. A drug delivery device as recited in claim 26, further comprising a plunger, the plunger comprising a knob and a push rod, the knob including a tapered portion configured for disposal in the tapered funnel bore such that the push rod extends through the tubular bore, the channels and the passageway.

31. A drug delivery device as recited in claim 26, further comprising a cannula that is coupled to the housing such that a lumen of the cannula is in communication with the second channel.

32. A drug delivery device as recited in claim 26, wherein the drug cartridge comprises a clear material and the housing comprising a viewing aperture such that the drug depot is viewable through the viewing aperture.

33. A drug delivery device comprising:

a housing comprising a first channel and a second channel that is in communication with the first channel;

a drug cartridge removably positioned in the first channel, the drug cartridge comprising a first plate including a first cantilever arm and a second plate including a second cantilever arm, the cantilever arms defining a passageway that is aligned with the second channel, the passageway having a drug depot positioned therein; and

a push rod configured to be positioned through the channels and the passageway to apply a force to the drug depot sufficient to deflect at least one of the cantilever arms to expel the drug depot from the passageway,

wherein the first cantilever arm comprises a first ramped protrusion and the second cantilever arm comprises a second ramped protrusion, the drug depot being positioned between the first ramped protrusion and the second ramped protrusion, the plates each comprising a half channel extending from an end of a respective plate along a body of the respective plate and a corresponding one of the cantilever arms up to a corresponding one of the ramped protrusions, the half channels being aligned together to define the passageway.

34. A drug delivery device as recited in claim 33, wherein the cantilever arms are each configured to occlude the passageway at an occluding position such that the drug depot cannot pass through the passageway at the occluding positions without force, greater than that of gravity, applied to the drug depot sufficient to deflect one of the cantilever arms an amount permitting passage of the drug depot past one of the cantilever arms.

35. A drug delivery device as recited in claim 33, wherein the first cantilever arm comprises a first ramped protrusion and the second cantilever arm comprises a second ramped protrusion, the drug depot being positioned between the first ramped protrusion and the second ramped protrusion.

36. A drug delivery device as recited in claim 33, further comprising a funnel body coupled to the housing such that the drug cartridge is positioned between the funnel body and the second channel, the funnel body comprising a tapered funnel bore and a tubular bore that is in communication with the passageway.

37. A drug delivery device as recited in claim 36, wherein the push rod includes a knob having a tapered portion configured for disposal in the tapered funnel bore such that the push rod extends through the tubular bore, the channels and the passageway.