Neural stimulation devices and systems for treatment of chronic inflammation

• US 10,384,068 B2
• Filed: 06/11/2018
• Issued: 08/20/2019
• Est. Priority Date: 12/23/2009
• Status: Active Grant

• Current Assignee: Setpoint Medical Corporation
• Original Assignee: Setpoint Medical Corporation
• Inventors: Faltys, Michael A., Simon, Jesse M., Liu, Yiming
• Primary Examiner(s): Lavert, Nicole F
• Application Number:
  US16/005,191
• Publication Number:
  US 20180289970A1
• Time in Patent Office: 435 Days
• Field of Search: 607 33, 607116, 607118
• CPC Class Codes: A61N 1/0556 Cuff electrodes
• CPC Class Codes: A61N 1/36053 adapted for vagal stimulation A61N1/36114 takes precedence
• CPC Class Codes: A61N 1/3606 adapted for a particular treatment
• CPC Class Codes: A61N 1/36125 Details of circuitry or electric components
• CPC Class Codes: A61N 1/36142 for improving safety
• CPC Class Codes: A61N 1/36175 Pulse width or duty cycle
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/37235 Aspects of the external programmer
• CPC Class Codes: A61N 1/375 Constructional arrangements, e.g. casings
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators
• CPC Class Codes: A61N 1/3787 from an external energy source

Abstract

A system for treating chronic inflammation may include an implantable microstimulator, a wearable charger, and optionally an external controller. The implantable microstimulator may be implemented as a leadless neurostimulator implantable in communication with a cervical region of a vagus nerve. The microstimulator can address several types of stimulation including regular dose delivery. The wearable charger may be worn around the subject'"'"'s neck to rapidly (<10 minutes per week) charge an implanted microstimulator. The external controller may be configured as a prescription pad that controls the dosing and activity of the microstimulator.

Claims

1. A charger device configured to be worn around a patient'"'"'s neck for charging a microstimulator implanted in the patient'"'"'s neck, the device comprising:

an energizer coil configured to fit around the patient'"'"'s neck;

a latch configured to releasably secure together two ends of the energizer coil to close the energizer coil and form a solenoid loop around the patient'"'"'s neck; and

a class-D amplifier driving the solenoid loop and configured to create a magnetic field of between about 40 and 100 A/m at a frequency of between about 120 and 140 KHz.

2. The device of claim 1, wherein the latch comprises a plurality of pins making electrical connection between the two ends of the energizer coil, the pins configured to maintain a low coil resistance and high Q.

3. The device of claim 1, wherein the class-D amplifier comprises a high efficiency class-D amplifier.

4. The device of claim 1, wherein the class-D amplifier is configured to be driven at a variable frequency to maximize power transfer.

5. The device of claim 1, wherein the class-D amplifier output is driven to optimize a microstimulator power absorption by measuring a back-telemetry modulation depth.

6. The device of claim 1, wherein the class-D amplifier controls temperature and prevents telemetry channel saturation.

7. The device of claim 1, further comprising a digitally compensated pulse width modulator (pwm) circuit to modulate a strength of the magnetic field and tune a power transfer to the microstimulator.

8. The device of claim 1, wherein the class-D amplifier driving the solenoid loop is configured to create the magnetic field of between about 47-94 A/m at a frequency of between about 127-135 KHz.

9. The device of claim 1, further comprising resonators that are adjustable to between about 127 KHz to 135 KHz.

10. The device of claim 1, further comprising a telemetry system.

11. The device of claim 10, wherein the telemetry system comprises a microprocessor configured to modulate a transmitter collector voltage to send data.

12. The device of claim 1, further comprising a display.

13. A charger device configured to be worn around a patient'"'"'s neck for charging a microstimulator implanted in the patient'"'"'s neck, the device comprising:

a solenoid loop configured to be worn around the patient'"'"'s neck; and

a class-D amplifier driving the solenoid loop and configured to create a magnetic field of between about 40 and 100 A/m at a frequency of between about 120 and 140 KHz.

14. The device of claim 13, further comprising a display configured to indicate one or more of a state of the microstimulator and a state of the device.

15. The device of claim 14, wherein the display is configured to indicate one or more of:

when the device is around the patient'"'"'s neck, when the device detects a presence of the microstimulator but has not started charged, when the microstimulator is charging, when an external controller is communicating with the microstimulator, when the device is in standby mode, an emergency shutoff display, and when the microstimulator is in an off state.

16. The device of claim 13, further comprising circuitry to modulate a strength of the magnetic field.

17. The device of claim 16, wherein the circuitry is configured to tune a power transfer to the microstimulator.

18. The device of claim 16, wherein the circuitry is configured to dynamically maximize power transfer and/or minimize side-lobe radiation outside an allocated frequency band.

19. The device of claim 13, wherein the device is configured to communicate with an external controller, the external controller configured to control aspects of the microstimulator when implanted within the patient'"'"'s body.

20. The device of claim 19, wherein the external controller is configured to set one or more of a dose amplitude and a dose interval for the microstimulator.