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Molecular complex for targeting antigens towards cells comprising antigens and uses thereof for vaccination

  • US 10,385,120 B2
  • Filed: 02/01/2011
  • Issued: 08/20/2019
  • Est. Priority Date: 02/01/2010
  • Status: Active Grant
First Claim
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1. An isolated immunogenic complex comprising at least one antigen associated with at least two protein or peptide ligands of surface molecules of antigen-presenting cells,said at least two protein or peptide ligands at least one first ligand of heparan sulfates and one second ligand of a surface molecule specific for antigen-presenting cells,wherein the first ligand is an isolated peptide consisting of the R domain of diphtheria toxin (SEQ ID NO:

  • 6);

    the second ligand is selected from the group consisting of;

    a BB fragment of Staphylococcus aureus protein A (SEQ ID NO;

         4) and a ZZ derivative thereof (SEQ ID NO;

         3),said antigen is a protein or a peptide which is specific for a tumor,said first ligand is covalently bonded to said antigen and to said second ligand,said complex does not comprise the full length diphtheria toxin, andsaid complex induces an anti-tumor immune response.

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