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Methods and compositions for the treatment of cancer

  • US 10,385,343 B2
  • Filed: 08/28/2015
  • Issued: 08/20/2019
  • Est. Priority Date: 08/29/2014
  • Status: Active Grant
First Claim
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1. A method of treating cancer, the method comprising administering a chimeric molecule comprising an EPCAM binding aptamer domain and an inhibitory nucleic acid domain,wherein the inhibitory nucleic acid inhibits the expression of Plk1and wherein the chimeric molecule is an aptamer-siRNA chimera (AsiC) comprising the sequence of SEQ ID NO:

  • 1 or SEQ ID NO;

    3.

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