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CHD risk stratification evaluations for subjects with high levels of large HDL-P

  • US 10,386,355 B2
  • Filed: 09/29/2016
  • Issued: 08/20/2019
  • Est. Priority Date: 04/27/2012
  • Status: Active Grant
First Claim
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1. A method of determining whether a subject with elevated concentrations of very large high density lipoprotein (HDL) particles (HDL-P) is at increased risk for a cardiac event and/or CHD, comprising:

  • providing a blood plasma or serum sample from the subject;

    obtaining NMR signal data of the blood plasma or serum sample from the subject;

    determining NMR derived concentration measurements of at least HPVS, HPML, and HPVL, where HPVS is a concentration of very small HDL-P subclasses, HPML is a concentration of medium and large HDL-P subclasses, and HPVL is a concentration of very large HDL-P subclasses;

    identifying when a subject has an elevated concentration of HPVL relative to a population norm, wherein the subject has an elevated concentration of HPVL when the subject'"'"'s concentration is ≥

    80% of a population norm; and

    calculating at least one HDL interaction risk parameter associated with HDL content of a blood plasma or serum sample of the subject, the at least one HDL interaction risk parameter comprising at least two of HPVS, HPML, and HPVL.

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