Sample handling system

• US 10,386,380 B2
• Filed: 12/05/2017
• Issued: 08/20/2019
• Est. Priority Date: 05/16/2007
• Status: Active Grant

• Current Assignee: Hitachi High-Tech Company Limited (Hitachi, Ltd.)
• Original Assignee: Hitachi High-Technologies Corporation (Hitachi, Ltd.)
• Inventors: Onizawa, Kuniaki, Obari, Koichi, Oizumi, Junichi, Oba, Shigemi, Abe, Tetsuaki
• Primary Examiner(s): Whatley, Benjamin R
• Application Number:
  US15/831,562
• Publication Number:
  US 20180095101A1
• Time in Patent Office: 623 Days
• CPC Class Codes: G01N 2001/1081 Storing samples under refrigeration
• CPC Class Codes: G01N 2035/00346 Heating or cooling arrangements
• CPC Class Codes: G01N 2035/00445 Other cooling arrangements
• CPC Class Codes: G01N 2035/0462 Buffers [FIFO] or stacks [LIFO] for holding carriers between operations
• CPC Class Codes: G01N 35/026 having blocks or racks of reaction cells or cuvettes
• CPC Class Codes: G05B 1/00 Comparing elements, i.e. elements for effecting comparison directly or indirectly between a desired value and existing or anticipated values

Abstract

A sample processing system is configured for analyzing, preprocessing, or carrying out other operations for a biological sample such as blood or urea. With the sample processing system, it is possible to store samples to be stored in a thermally insulated state or specimens required for accuracy control in the thermally insulated state for preventing evaporation or denaturing of the samples and specimens. Also it is possible to carry in or out the samples, rack by rack, according to necessity. Further, the sample processing system is provided with a buffer unit in a cold container having a capability for cold storage and also by accessing a sample rack at random for carrying in or out a rack with a transfer mechanism provided outside of the cold container.

Claims

1. A sample handling system comprising:

a sample processing unit for processing samples;

a buffer unit for temporarily receiving a plurality of sample racks, each sample rack holding samples therein, the buffer unit including a buffer unit transfer section;

a main transfer section for transferring the sample racks between the buffer unit and the sample processing unit;

a buffer unit transfer mechanism for transferring the sample racks, on each of which sample racks at least one sample can be mounted, in the transfer section of the buffer unit-;

a cold container in the buffer unit to refrigerate and to store samples held on ones of the sample racks;

a cold container rack transfer mechanism usable to randomly access the ones of the sample racks stored in the cold container, the cold container rack transfer mechanism including a sample rack holding bucket and a carriage to engage a sample rack positioned in the sample rack holding bucket and to move the sample rack between the sample rack holding bucket and the cold container;

at least one stand-by position of the sample rack holding bucket adjacent the cold container, in which at the at least one stand-by position, the rack is carried between the cold container and the sample rack holding bucket by the carriage; and

a door in the cold container, the carriage carrying the sample rack between the sample rack holding bucket in the at least one stand-by position and the cold container when the door in the cold container is open.

2. The sample handling system according to claim 1, and including an operating section and wherein, when a number of openings and closings of the door of the cold container, in a unit of time, exceeds a prespecified value stored in the operating section, an alarm signal is output to the operating section.

3. The sample handling system according to claim 2, wherein the prespecified value can be set in the operating section.

4. The sample handling system according to claim 1, further including a carriage drive motor and a sample rack holding bucket drive motor, the carriage drive motor and the sample rack holding bucket drive motor being part of the cold container rack transfer mechanism, the sample rack bucket drive motor being operable to position the sample rack holding bucket in the at least one stand-by position.

5. A sample handling system comprising:

a sample processing unit for processing samples;

a buffer unit for temporarily receiving a plurality of sample racks, each sample rack holding samples therein; and

a main transfer section for transferring the sample racks between the buffer unit and the sample processing unit, wherein the buffer unit includes;

a buffer unit transfer section and including a buffer unit transfer mechanism for transferring the sample racks in the transfer section of the buffer unit;

a cold storage section in the buffer unit and having a cold container with a thermally insulating function to hold first ones of the sample racks in a horizontal plane of the buffer unit, with thermal control, in a cooling condition and which ones of the sample racks have been temporarily held in the buffer unit;

a cooler on the cold container, which cooler maintains the first ones of the sample racks held in the cold container of the buffer unit in the cooling condition;

a buffer section in the buffer unit for holding second ones of the sample racks in the horizontal plane of the buffer unit, the second ones of the sample racks excluding the first ones of the sample racks requiring the thermal control and first which ones of the sample racks have been placed in the cold container of the cold storage section of the buffer unit, and

wherein the buffer unit transfer section includes;

a cold container rack transfer mechanism, and including a sample rack holding bucket, the cold container rack transfer mechanism transferring the first ones of the sample racks between the cold container of the cold storage section, and the sample rack holding bucket;

a carriage to engage individual ones of the first ones of the plurality of sample racks and to move the individual ones of the first ones of the sample racks between the bucket and the cold container of the cold storage section;

a sample rack holding bucket drive motor and a carriage drive motor in the rack transfer mechanism; and

at least one stand-by position of the sample rack holding bucket and in which at least one stand-by position a sample rack is carried between the cold container and the sample rack holding bucket by operation of the carriage drive motor.