Method, system and program for improved health care

• US 10,387,406 B2
• Filed: 03/08/2012
• Issued: 08/20/2019
• Est. Priority Date: 03/10/2011
• Status: Active Grant

• Current Assignee: Seegnal EHealth Ltd.
• Original Assignee: Mediseen Ehealth Ltd.
• Inventors: Shiloh, Ron Zeev
• Primary Examiner(s): Le, Linh Giang
• Application Number:
  US14/000,976
• Publication Number:
  US 20150058039A1
• Time in Patent Office: 2,721 Days
• CPC Class Codes: G06F 16/24 Querying
• CPC Class Codes: G16H 10/60 for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 70/40 relating to drugs, e.g. their side effects or intended usage

Abstract

A platform accessible by a user from a web browser/HMO'"'"'s electronic medical record (EMR) for providing the user with information regarding a patient'"'"'s drug regimen as well as generating alerts concerning potential adverse effects to a patient from taking a cluster including a plurality of pharmaceutical preparations and various food supplements/herbals may be in data communication with and configured to obtain information from at least two databases and at least one tool for processing the cluster of pharmaceutical preparations in accordance with the information to generate the alerts to the user.

Claims

1. A drug-to-drug interaction (DDI) platform for facilitating selection of a poly-pharmaceutical treatment of a patient being treated simultaneously with multiple prescribed drugs, by interactive access of a user via a graphical user interface (GUI) presented on a display from a web browser or an electronic medical record (EMR), the DDI platform comprising a processor configured to:

identify one or more currently prescribed drugs associated with the patient'"'"'s drug regimen from the patient'"'"'s EMR;

receive, via the GUI, a selection from the user for a first drug not currently prescribed to the patient;

query a DDI database for information relating to the one or more currently prescribed drugs and information relating to the first drug not currently prescribed;

obtain, from the DDI database, the information relating to the one or more currently prescribed drugs and the information relating to the first drug not currently prescribed, wherein the information relating to the one or more currently prescribed drugs comprises at least one side effect caused by the one or more currently prescribed drugs, and wherein the information relating to the first drug not currently prescribed comprises at least one side effect caused by the first drug not currently prescribed;

determine, based on the at least one side effect caused by the one or more currently prescribed drugs and the at least one side effect caused by the first drug not currently prescribed a first shared side effect common to at least one drug of the one or more currently prescribed drugs and the first drug not currently prescribed;

identify a first severity level related to the first shared side effect when independently caused by the at least one drug of the one or more currently prescribed drugs and a second severity level related to the first shared side effect when independently caused by the first drug not currently prescribed, where the first severity level and the second severity level are each below a predefined threshold value for alerting the user;

run a shared adverse side effect (SASE) predictor to;

predict a combined severity level related to the first shared side effect that is at least partially caused by the at least one drug of the one or more currently prescribed drugs and the first drug not currently prescribed; and

detect, based upon one or more rules accessible by a rules and alert engine, whether the combined severity level exceeds the predefined threshold value for alerting the user;

updating the GUI to present an alert when the combined severity level is detected as exceeding the predefined threshold value, wherein the updating of the GUI presents an indication that the combined severity level of the first shared side effect is above the threshold value and an indication of a DDI between the at least one drug of the one or more currently prescribed drugs and the first drug not currently prescribed, such that the user is notified of the first shared side effect and the DDI;

dynamically receiving, via the GUI, an input instructing modification of at least one of the one or more currently prescribed drugs and the first drug not currently prescribed to the patient, the modification including at least one of a replacement, a removal, and addition of a new drug;

dynamically iterating the updating of the GUI to present the alert, according to the dynamically received input instructing modification, the query the DDI database, the obtain information, the determine the first shared side effect, the identify the first severity level, and the run the SASE predictor,

wherein the alert presented in the updated GUI is indicative of quality of treatment of a prescribed poly-pharmaceutical treatment comprising the modified one or more currently prescribed drugs and the first drug not currently prescribed to the patient; and

when the combined severity level is detected as below the predefined threshold value, generating instructions for treatment of the patient with the prescribed poly-pharmaceutical treatment comprising the modified one or more currently prescribed drugs and the first drug not currently prescribed to the patient.

2. The DDI platform of claim 1, wherein the GUI is accessible by the user from the web browser or the EMR program.

3. The DDI platform of claim 1, wherein the processor is further configured to display the first shared side effect, the DDI, and an indication of the at least one drug on the GUI.

4. The DDI platform of claim 1, wherein the GUI further presents a range indicating how frequently the at least one drug, when taken together, cause in the first shared side effect, and wherein the threshold value is a lower bound of the range.

5. The DDI platform of claim 1, processor is further configured to:

receive, via the GUI, a selection from the user for a second drug not currently prescribed to the patient;

query the DDI database for information relating to the second drug not currently prescribed; and

receive, from the DDI database, the information relating to the second drug not currently prescribed;

determine, based on the one or more currently prescribed drugs, the second drug not currently prescribed, the information relating to the one or more currently prescribed drugs, and the information relating to the second drug not currently prescribed, that a second shared side effect of the one or more currently prescribed drugs and the second drug not currently prescribed is below the threshold value.

6. The DDI platform of claim 5, wherein the processor is further configured to receive, via the GUI, a selection from the user to replace one of the one or more currently prescribed drugs with the second drug not currently prescribed or to add the second drug not currently prescribed to the one or more currently prescribed drugs.

7. The DDI platform of claim 1, wherein the processor is further configured to update the GUI with a suggestion of at least one alternative drug to replace one of the one or more currently prescribed drugs or the first drug not currently prescribed.

8. The DDI platform of claim 7, wherein the processor is further configured to update the GUI with systematically suggested alternatives to each of the one or more currently prescribed drugs and the first drug not currently prescribed until no more than an acceptable number of indications regarding potential adverse effects above a preconfigured significance threshold are generated.

9. The DDI platform of claim 1, wherein the processor is further configured to updated the GUI with generated indications of potentially harmful effects of drug combinations based on the one or more rules, wherein the one or more rules are pre-defined rules or rules defined by the user.

10. The DDI platform of claim 9, wherein at least one rule relates to a healthcare burden of the one or more currently prescribed drugs and the first drug not currently prescribed.

11. The DDI platform of claim 1, wherein the processor is further configured to receive, from a blood serum level database, information relating to the effects of the combination of the one or more currently prescribed drugs and the first drug not currently prescribed on blood serum levels of the patient.

12. The DDI platform of claim 1, wherein the processor is further configured to collect and aggregate statistical information relating to the one or more currently prescribed drugs and the first drug not currently prescribed, and the first shared side effect.

13. The DDI platform of claim 1, wherein the processor is further configured to update the GUI with predicted costs resulting from the first shared side effect or the DDI to the patient from taking the one or more currently prescribed drugs and the first drug not currently prescribed, wherein the predicted costs include at least one of admission to hospital, duration of hospitalization, referrals to emergency rooms, sessions with general practitioners, sessions with specialist physicians, or at least one diagnostic technique, wherein the at least one diagnostic technique comprises at least one of computed tomography, Magnetic Resonance Imaging, Ultra Sound, or X-ray.

14. The DDI platform of claim 1, wherein a warning is displayed in the EMR of the patient when the DDI platform generates the indication for the combined severity level of the first shared side effect.