Systems and methods for predicting adverse events and assessing level of sedation during medical procedures
First Claim
1. A system for automatically providing a quantitative assessment of a physiological state of a patient during procedural sedation, the system comprising:
- a breath receiver in fluid communication with a patient undergoing procedural sedation;
a sensor configured to measure a carbon dioxide concentration in air captured by the breath receiver, the sensor being coupled to the breath receiver;
a processor configured to;
generate, in real time, a capnogram associated with the patient, the capnogram being generated based on the carbon dioxide concentration measured by the sensor over one or more respiratory cycles;
extract, in real time, one or more features from the capnogram that are indicative of the physiological state of the patient;
determine, in real time, using a clustering technique, clusters of the one or more features indicative of the physiological state of the patient, wherein each of the clusters corresponds to a different physiological state;
compute, in real time, a metric indicative of the physiological state of the patient based, at least in part, on the determined clusters;
determine a baseline value of the metric for the patient, the baseline value corresponding to a baseline physiological state of the patient before procedural sedation begins; and
monitor, in real time, a value of the metric relative to the baseline value to assess the physiological state of the patient during the procedural sedation, wherein monitoring the value of the metric relative to the baseline value comprises determining the physiological state of the patient based, at least in part, on the determined clusters; and
a display configured to display an indication of the assessed physiological state of the patient during the procedural sedation.
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Accused Products
Abstract
Systems and methods are disclosed herein for quantitatively identifying a patient'"'"'s sedation level and predicting adverse events, based on one or more capnograms or outputs from a pharmacokinetic, pharmacodynamic, or ventilatory model. A sensor measures a carbon dioxide concentration of air exhaled by a patient into a breath receiver. A processor processes the sensor data to generate a capnogram including one or more respiratory cycles, computes the outputs of pharmacokinetic, pharmacodynamic, or ventilatory models, and extracts one or more of the resulting features from the capnogram and pharmacokinetic, pharmacodynamic, or ventilatory model outputs. A multi-parameter metric is computed based on the one or more extracted features and estimates the current or predicted sedation level of the patient.
42 Citations
15 Claims
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1. A system for automatically providing a quantitative assessment of a physiological state of a patient during procedural sedation, the system comprising:
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a breath receiver in fluid communication with a patient undergoing procedural sedation; a sensor configured to measure a carbon dioxide concentration in air captured by the breath receiver, the sensor being coupled to the breath receiver; a processor configured to; generate, in real time, a capnogram associated with the patient, the capnogram being generated based on the carbon dioxide concentration measured by the sensor over one or more respiratory cycles; extract, in real time, one or more features from the capnogram that are indicative of the physiological state of the patient; determine, in real time, using a clustering technique, clusters of the one or more features indicative of the physiological state of the patient, wherein each of the clusters corresponds to a different physiological state; compute, in real time, a metric indicative of the physiological state of the patient based, at least in part, on the determined clusters; determine a baseline value of the metric for the patient, the baseline value corresponding to a baseline physiological state of the patient before procedural sedation begins; and monitor, in real time, a value of the metric relative to the baseline value to assess the physiological state of the patient during the procedural sedation, wherein monitoring the value of the metric relative to the baseline value comprises determining the physiological state of the patient based, at least in part, on the determined clusters; and a display configured to display an indication of the assessed physiological state of the patient during the procedural sedation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for automatically providing a quantitative assessment of a physiological state of a patient during procedural sedation, the method comprising:
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receiving, at a processor, from a sensor, data indicating a carbon dioxide concentration in air captured by a breath receiver, the sensor being coupled to the breath receiver; generating, in real time, a capnogram associated with the patient, the capnogram being generated based on the carbon dioxide concentration measured by the sensor over one or more respiratory cycles; extracting, in real time, one or more features from the capnogram that are indicative of a physiological state of the patient; determining, in real time, using a clustering technique, clusters of the one or more features indicative of the physiological state of the patient, wherein each of the clusters corresponds to a different physiological state; computing, in real time, a metric indicative of a physiological state of the patient based, at least in part, on the determined clusters; determining a baseline value of the metric for the patient, the baseline value corresponding to a baseline physiological state of the patient before procedural sedation begins; and monitoring, in real time, a value of the metric relative to the baseline value to assess the physiological state of the patient during the procedural sedation, wherein monitoring the value of the metric relative to the baseline value comprises determining the physiological state of the patient based, at least in part, on the determined clusters; and displaying an indication of the assessed physiological state of the patient during the procedural sedation.
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Specification