Photoplethysmography sensors

• US 10,390,715 B2
• Filed: 10/12/2012
• Issued: 08/27/2019
• Est. Priority Date: 06/29/2012
• Status: Active Grant

• Current Assignee: Xhale Assurance, Inc. (Koninklijke Philips N.V.), University of Florida Research Foundation, Incorporated (State University System of Florida)
• Original Assignee: University of Florida Research Foundation, Incorporated (State University System of Florida)
• Inventors: Rich, David, Melker, Richard J., Kersey, Andrew, Culen, Matt
• Primary Examiner(s): Smith, Ruth S
• Application Number:
  US13/650,310
• Publication Number:
  US 20140005557A1
• Time in Patent Office: 2,510 Days
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/0878 using temperature sensing means
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/6819 Nose

Abstract

Provided according to embodiments of the invention are photoplethysmography (PPG) sensors, systems and accessories, and methods of making and using the same. In some embodiments of the invention, the PPG sensors include a clip body that includes a first end portion and a second end portion; a flex circuit attached or adjacent to the clip body, and an elastomeric sleeve that envelops (1) at least part of the first end portion and at least part of the flex circuit attached or adjacent thereto; or (2) at least part of the second end portion and at least part of the flex circuit attached or adjacent thereto.

Claims

1. A photoplethysmography (PPG) sensor comprising:

(a) a clip body comprising a first end portion facing a second end portion, wherein the clip body comprises a first aperture in the first end portion and a second aperture in the second end portion;

(b) a flex circuit attached or adjacent to the clip body, wherein the flex circuit generally conforms to a curvature of the clip body,

wherein the flex circuit comprises a light emitter within or adjacent to the first aperture, a light detector within or adjacent to the second aperture, and at least one of a nasal air pressure detector and a nasal air flow detector,

wherein the light emitter emits at least one of visible, infrared and ultraviolet light, and wherein the light emitter is facing the light detector, which detects the light from the light emitter; and

(c) a first elastomeric sleeve that envelops a part of the first end portion and a part of the flex circuit attached or adjacent thereto that comprises the light emitter; and

a second elastomeric sleeve that envelops at least part of the second end portion and a part of the flex circuit attached or adjacent thereto that comprises the light detector.

2. The PPG sensor of claim 1, wherein no adhesive is present between the clip body and the flex circuit, between the clip body and the first elastomeric sleeve, between the flex circuit and the first elastomeric sleeve, between the clip body and the second elastomeric sleeve, or between the flex circuit and the second elastomeric sleeve.

3. The PPG sensor of claim 1, wherein the first end portion is configured to secure to an external tissue of a nasal alar, and the second end portion is configured to secure to an internal tissue of the nasal alar.

4. The PPG sensor of claim 3, wherein the clip body generally conforms to a curvature of a nasal tissue secured between the first end portion and the second end portion.

5. The PPG sensor of claim 1, wherein the clip body is a flexible molded polymer clip.

6. The PPG sensor of claim 1, wherein the clip body is opaque.

7. The PPG sensor of claim 1, wherein the clip body is U-shaped.

8. The PPG sensor of claim 1, wherein the first and second elastomeric sleeves bind the clip body and the flex circuit together, and no adhesive is present between the clip body and the flex circuit, between the clip body and the elastomeric sleeves or between the flex circuit and the elastomeric sleeves.

9. The PPG sensor of claim 1, wherein the first and second elastomeric sleeves comprise at least one elastomer selected from a group consisting of silicone, polyurethane, polyvinyl chloride and styrene-based copolymers.

10. The PPG sensor of claim 1, wherein a surface of the first and second elastomeric sleeves configured to contact a body tissue is smooth.

11. The PPG sensor of claim 1, wherein the first and second elastomeric sleeves are transparent.

12. The PPG sensor of claim 1, wherein at least one of the first and second elastomeric sleeves comprises an opaque portion and transparent portion.

13. The PPG sensor of claim 12, wherein the at least one of the first and second elastomeric sleeves is opaque except for a transparent window defined therein.

14. The PPG sensor of claim 1, wherein the at least one of a nasal air pressure detector and a nasal air flow detector is not enveloped by the first elastomeric sleeve or the second elastomeric sleeve.

15. The PPG sensor of claim 1, wherein the at least one of a nasal air pressure detector and a nasal air flow detector comprises a thermistor.

16. The PPG sensor of claim 1, wherein the clip body comprises an additional aperture, and the nasal air pressure or nasal air flow detector is within or adjacent to the additional aperture.

17. The PPG sensor of claim 1, wherein the flex circuit is configured to interface, directly or indirectly, with a signal processing device.

18. The PPG sensor of claim 1, wherein at least part of the first end portion is concave and at least part of the second end portion is convex.

19. A system for monitoring a subject, comprising:

a photoplethymography (PPG) sensor that comprises;

(a) a clip body comprising a first end portion facing a second end portion, wherein the clip body comprises an aperture in the first end portion and an aperture on the second end portion;

(b) a flex circuit attached or adjacent to the clip body, wherein the flex circuit generally conforms to a curvature of the clip body,

wherein the flex circuit comprises a light emitter within or adjacent to the first aperture, a light detector within or adjacent to the second aperture, and at least one of a nasal air pressure detector and a nasal air flow detector,

wherein the light emitter emits at least one of visible, infrared and ultraviolet light, and wherein the light emitter is facing the light detector, which detects the light from the light emitter; and

(c) a first elastomeric sleeve that envelops a part of the first end portion and a part of the flex circuit attached or adjacent thereto that comprises the light emitter; and

a second elastomeric sleeve that envelops at least part of the second end portion and a part of the flex circuit attached or adjacent thereto that comprises the light detector; and

a computer communicatingly connected to the PPG sensor.

20. The system of claim 19, wherein the computer comprises a processing module configured to process PPG signals from the PPG sensor to determine the respiratory rate of the subject.

21. The system of claim 19, wherein the computer comprises a processing module configured to process PPG signals from the PPG sensor to monitor blood flow in the subject.

22. The system of claim 19, wherein the PPG sensor is configured to secure to a nasal alar of the subject.