Multimodal brain sensing lead

• US 10,390,721 B2
• Filed: 04/03/2017
• Issued: 08/27/2019
• Est. Priority Date: 11/10/2011
• Status: Active Grant

• Current Assignee: Neuropace Inc.
• Original Assignee: Neuropace Inc.
• Inventors: Tcheng, Thomas K.
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Pahakis, Manolis
• Application Number:
  US15/478,168
• Publication Number:
  US 20170238832A1
• Time in Patent Office: 876 Days
• Field of Search: None
• CPC Class Codes: A61B 2562/0209 Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 2562/0285 Nanoscale sensors
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 2562/063 in a linear array
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue
• CPC Class Codes: A61B 5/165 Evaluating the state of mind, e.g. depression, anxiety
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/4082 Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6868 Brain
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence
• CPC Class Codes: A61N 1/025 Digital circuitry features of electrotherapy devices, e.g. memory, clocks, processors
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 : Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/36064 : Epilepsy
• CPC Class Codes: A61N 1/36067 : Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36082 : Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36132 : using patient feedback
• CPC Class Codes: A61N 1/36139 : with automatic adjustment

Abstract

A medical lead with at least a distal portion thereof implantable in the brain of a patient is described, together with methods and systems for using the lead. The lead is provided with at least two sensing modalities (e.g., two or more sensing modalities for measurements of field potential measurements, neuronal single unit activity, neuronal multi unit activity, optical blood volume, optical blood oxygenation, voltammetry and rheoencephalography). Acquisition of measurements and the lead components and other components for accomplishing a measurement in each modality are also described as are various applications for the multimodal brain sensing lead.

Claims

1. A system for measuring physiological information from a patient, the system comprising:

a lead configured to be implanted in the patient, the lead comprising;

a body having a distal portion,

a plurality of lead components at the distal portion, wherein the plurality of lead components includes a plurality of macroelectrodes, a plurality of microelectrodes, and at least one optical assembly, and

a lead electronics module comprising a lead signal processor configured to process signals from one or more of the plurality of lead components to obtain at least one of a plurality of first measurements including a neuronal single unit activity measurement, a neuronal multi unit activity measurement, an optical blood volume measurement, or an optical blood oxygenation measurement; and

a host coupled to the lead, the host comprising;

a host control module configured to generate and output host control signals,

a host power supply configured to provide power, and

a host signal processor configured to process signals from one or more of the plurality of lead components to obtain at least one of a plurality of second measurements including neuronal field potential measurement or a rheoencephalography measurement,

wherein the host control module and the host power supply are electrically coupled to the lead electronics module, and the lead electronics module is configured to selectively enable, based on the host control signals;

a) a first sensing modality that provides one of the plurality of first measurements to the host by electrically coupling at least one of the plurality of lead components to at least one of;

i) an input to the lead signal processor, and ii) the host power supply, and electrically coupling an output of the lead signal processor to the host, and

b) a second sensing modality that enables the host signal processor to obtain one of the plurality of second measurement by electrically coupling at least one of the plurality of lead components to the host signal processor, bypassing the lead signal processor.

2. The system of claim 1, wherein:

the lead electronics module is configured to electrically couple a first microelectrode to a first input of the lead signal processor and electrically couple a second microelectrode to a second input of the lead signal processor, to selectively enable the first sensing modality that provides a first measurement corresponding to the single unit activity measurement and the multi unit activity measurement, and electrically couple an output of lead signal processor to the host.

3. The system of claim 2, wherein the lead signal processor comprises an amplifier and the first input corresponds to a first input of the amplifier, and the second input corresponds to a second input of the amplifier.

4. The system of claim 1, wherein:

the lead electronics module is configured to electrically couple a microelectrode to a first input of the lead signal processor and electrically couple a macroelectrode to a second input of the lead signal processor, to selectively enable the first sensing modality that provides a first measurement corresponding to the single unit activity measurement and the multi unit activity measurement, and electrically couple an output of the lead signal processor to the host.

5. The system of claim 4, wherein the lead signal processor comprises an amplifier and the first input corresponds to a first input of the amplifier, and the second input corresponds to a second input of the amplifier.

6. The system of claim 1, wherein:

the at least one optical assembly comprises at least one light emitting diode (LED) and at least one photodetector, and

the lead electronics module is configured to electrically couple a LED to the host power supply to illuminate the LED and electrically couple a photodetector to an input of the lead signal processor, to selectively enable the first sensing modality that provides a first measurement corresponding to either of the optical blood volume measurement, or the optical blood oxygenation measurement, and electrically couple an output of the lead signal processor to the host.

7. The system of claim 6, wherein:

the lead signal processor comprises an amplifier and an analog-to-digital convertor, wherein an output of the amplifier is coupled to an input of an analog-to-digital convertor, and

the input of the lead signal processor corresponds to an input of the amplifier, and the output of the lead signal processor corresponds to an output of the analog-to-digital convertor.

8. The system of claim 1, wherein:

the lead electronics module is configured to electrically couple a first macroelectrode to the host signal processor, to selectively, enable the second sensing modality that enables the host signal processor to obtain a second measurement corresponding to the field potential measurement and to electrically couple a second macroelectrode to the host signal processor.

9. The system of claim 1, wherein:

the lead electronics module is configured to electrically couple each of a first macroelectrode, a second macroelectrode, a third macroelectrode, and a fourth macroelectrode to the host signal processor to selectively, enable the second sensing modality that enables the host signal processor to obtain a second measurement corresponding to the rheoncephalography measurement.

10. The system of claim 1, wherein the host control module is configured to change control signals during a period of time, and the lead electronics module is configured to, based on a change in control signals:

electrically couple a first set of the plurality of lead components to the lead signal processor to obtain at least one of the plurality of first measurements for a first portion of the period of time, and

electrically couple a second set of the plurality of lead components to the host signal processor to obtain one of the plurality of second measurements for a second portion of the period of time.

11. The system of claim 10, wherein the host control module is further configured to change control signals during the period of time, and the lead electronics module is configured to, based on a change in control signals, to electrically couple a third set of the plurality of lead components to the lead signal processor to obtain another one of the plurality of first measurements for a third portion of the period of time.

12. The system of claim 1, wherein the host control module is configured to change control signals during a period of time, and the lead electronics module is configured to, based on a change in control signals:

electrically couple a first set of the plurality of lead components to the lead signal processor to obtain a first of the plurality of first measurements for a first portion of the period of time, and

electrically couple a second set of the plurality of lead components to the lead signal processor to obtain a second of the plurality of first measurements for a second portion of the period of time, while electrically decoupling the first set of the plurality of lead components from the lead signal processor to suspend the obtaining of the first of the plurality of first measurements.

13. The system of claim 12, wherein the first of the plurality of first measurements is an activity measurement and the second of the plurality of first measurements is a voltammetry measurement.

14. The system of claim 1, wherein the host control module is configured to change control signals during a period of time, and the lead electronics module is configured to, based on a change in control signals:

electrically couple a first set of the plurality of lead components to the host signal processor to obtain a first of the plurality of second measurements for a first portion of the period of time, and

electrically couple a second set of the plurality of lead components to the host signal processor to obtain a second of the plurality of second measurements for a second portion of the period of time, while electrically decoupling the first set of the plurality of lead components from the host signal processor to suspend the obtaining of the first of the plurality of second measurements.

15. The system of claim 14, wherein the first of the plurality of second measurements is a field potential measurement and the second of the plurality of second measurements is a rheoencephalography measurement.

16. The system of claim 1, wherein:

the host further comprises a therapy module configured to output an electrical stimulation signal,

the lead electronics module is electrically coupled to the therapy module,

the host control module is configured to output control signals during a period of time, and

the lead electronics module is configured to, based on the control signals, electrically couple one or more of the plurality of lead components to the therapy module to deliver the electrical stimulation signal to the patient.

17. The system of claim 16, wherein the host control module is configured to output control signals during the period of time, and the lead electronics module is configured to, based the control signals, electrically couple a first set of the plurality of lead components to the lead signal processor to obtain a first of the plurality of first measurements during the period of time.

18. The system of claim 17, wherein the first of the plurality of first measurements is an optical measurement.

19. The system of claim 16, wherein the host control module is configured to output control signals during the period of time, and the lead electronics module is configured to, based on the control signals, suspend the obtaining of a second of the plurality of first measurements.

20. The system of claim 19, wherein the second of the plurality of first measurements is an activity measurement.

21. The system of claim 16, wherein the host control module is configured to output control signals during the period of time, and the lead electronics module is configured to, in response to the control signals, suspend the obtaining of a first of the plurality of second measurements.

22. The system of claim 21, wherein the first of the plurality of second measurements is a field potential measurement.