Methods, systems, and apparatuses for tissue ablation using electrolysis and permeabilization
First Claim
1. A method for tissue ablation, the method comprising:
- permeabilizing cell membranes in the tissue; and
performing electrolysis to deliver electrons to and remove electrons from the tissue thereby generating products of electrolysis in the tissue, wherein said products of electrolysis are toxic to cells in the tissue.
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Abstract
Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis treatment and cellular permeabilization treatment to a site in tissue. A system disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through the aqueous matrix to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site. The composition of the electrodes may be chosen in accordance with the desired products produced and electroporation effects. An apparatus is disclosed that may be in the form of electrodes the electrolysis and electrodes for electroporation applied to the tissue. An apparatus is disclosed that may be used for treating internal tissue.
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Citations
34 Claims
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1. A method for tissue ablation, the method comprising:
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permeabilizing cell membranes in the tissue; and performing electrolysis to deliver electrons to and remove electrons from the tissue thereby generating products of electrolysis in the tissue, wherein said products of electrolysis are toxic to cells in the tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. An apparatus for tissue ablation, the apparatus comprising:
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a source of products of electrolysis, wherein the source is configured to generate products of electrolysis through an electrochemical reaction of electrolysis by delivering electrons to or removing electrons from ions in the tissue, and the source is positioned proximal the tissue; and a device configured to permeabilize cell membranes in the tissue. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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Specification