Medical devices incorporating thermoelectric transducer and controller

• US 10,390,991 B2
• Filed: 08/14/2012
• Issued: 08/27/2019
• Est. Priority Date: 01/11/2007
• Status: Active Grant

• Current Assignee: Scion Neurostim Incorporated
• Original Assignee: Scion Neurostim, LLC
• Inventors: Rogers, Lesco L., von Windheim, Jesko, Lee, Seri
• Primary Examiner(s): Kim, Eun Hwa
• Application Number:
  US13/584,853
• Publication Number:
  US 20120310313A1
• Time in Patent Office: 2,569 Days
• CPC Class Codes: A61F 2007/0075 using a Peltier element, e.g. near the spot to be heated or cooled
• CPC Class Codes: A61F 7/007 characterised by electric heating
• CPC Class Codes: F25B 21/02 using Peltier effect; using Nernst-Ettinghausen effect
• CPC Class Codes: F25B 2321/021 Control thereof
• CPC Class Codes: H10N 10/17 characterised by the structure or configuration of the cell or thermocouple forming the device

Abstract

A temperature control system may include a thermoelectric device, a controller electrically coupled to the thermoelectric device, a heat transfer structure thermally coupled to the thermoelectric device, a temperature controlled medium thermally coupled to the thermoelectric device and a temperature feedback sensor. The controller may be configured to sense a first value of an electrical characteristic of the thermoelectric device and to generate a first electrical control to activate the thermoelectric device in response to sensing the first value of the electrical characteristic of the thermoelectric device. The controller may be further configured to sense a second value of the electrical characteristic of the thermoelectric device and to generate a second electrical control signal to activate the thermoelectric device in response to sensing the second value of the electrical characteristic of the thermoelectric device.

Claims

1. A temperature control system comprising:

a thermoelectric device;

a controller electrically coupled to the thermoelectric device and configured to sense an electrical characteristic of the thermoelectric device;

a heat transfer structure thermally coupled to a first side of the thermoelectric device;

a temperature controlled medium thermally coupled to a second side of the thermoelectric device so that the thermoelectric device is thermally coupled between the heat transfer structure and the temperature controlled medium, wherein said temperature controlled medium comprises a medical instrument configured to contact living tissue; and

a temperature feedback sensor, wherein said controller is configured to generate a first electrical control signal to activate said thermoelectric device and said first electrical control signal is generated in response to a first value of the electrical characteristic of the thermoelectric device, wherein the electrical characteristic of the thermoelectric device comprises an electrical characteristic of the thermoelectric device indicating one of a temperature gradient across the thermoelectric device and a temperature of the temperature controlled medium.

2. The temperature control system of claim 1, wherein said electrical characteristic comprises a voltage across the thermoelectric device.

3. The temperature control system of claim 1, wherein said electrical characteristic comprises a current through the thermoelectric device.

4. The temperature control system of claim 1, wherein said electrical characteristic comprises a resistance of the thermoelectric device.

5. The temperature control system of claim 1, wherein said first electrical control signal is generated in response to temperature feedback data generated by the temperature feedback sensor.

6. The temperature control system of claim 1, wherein said controller is configured to generate a second electrical control signal to activate said thermoelectric device, said second electrical signal being generated in response to a second value of the electrical characteristic of the thermoelectric device and/or in response to temperature feedback data generated by the temperature feedback sensor.

7. The temperature control system of claim 1, wherein said controller is configured to cyclically activate the thermoelectric device.

8. The temperature control system of claim 1, wherein said controller is configured to provide thermal pulses to the temperature controlled medium.

9. The temperature control system of claim 1, wherein said controller is configured to maintain a stable temperature of the temperature controlled medium.

10. The temperature control system of claim 1, wherein said controller is configured to cyclically alter the temperature profile of the temperature controlled medium.

11. The temperature control system of claim 1, wherein said controller is configured to provide a temperature ramp for the temperature controlled medium.

12. The temperature control system of claim 1, wherein said controller is configured to cool the tissue adjacent to said temperature controlled medium between about 1 and about 20 degrees Centigrade.

13. The temperature control system of claim 1, wherein said controller is configured to heat the tissue adjacent to said temperature controlled medium between about 1 and about 20 degrees Centigrade.

14. The temperature control system of claim 1, wherein said medical instrument is configured to be insertable into an ear canal of a subject.

15. The temperature control system of claim 1, wherein said medical instrument is a vestibular system stimulator.

16. The temperature control system of claim 15, wherein said vestibular system stimulator is configured to deliver caloric vestibular stimulation.

17. The temperature control system of claim 1, wherein said medical instrument is a nerve stimulation probe.

18. The temperature control system of claim 17, wherein said nerve stimulation probe is a vagal nerve stimulation probe.

19. A method of treating a subject, comprising:

positioning the temperature controlled medium of claim 1 in an ear canal of a subject; and

activating the thermoelectric device of claim 1 sufficient to treat the subject.

20. A method of delivering caloric vestibular stimulation to a subject, comprising:

positioning the temperature controlled medium of claim 1 in an ear canal of a subject; and

activating the thermoelectric device of claim 1 to deliver caloric vestibular stimulation to the subject.

21. A method of stimulating a nerve in a subject in need thereof, comprising:

positioning the temperature controlled medium of claim 1 in an ear canal of a subject; and

activating the thermoelectric device of claim 1 to stimulate a nerve.

22. A method of reducing pain in a subject, comprising:

positioning the temperature controlled medium of claim 1 in an ear canal of a subject; and

activating the thermoelectric device of claim 1 to treat migraine headache pain.

23. The temperature control system of claim 1, wherein the controller is configured to provide thermal pulses from about one-half second to about two minutes in duration.

24. A temperature control system comprising:

a thermoelectric device;

a controller electrically coupled to the thermoelectric device;

a heat transfer structure thermally coupled to a first side of the thermoelectric device; and

a temperature controlled medium thermally coupled to a second side of the thermoelectric device so that the thermoelectric device is thermally coupled between the heat transfer structure and the temperature controlled medium, wherein said temperature controlled medium comprises a medical instrument configured to contact living tissue,

wherein said controller is configured to cyclically activate the thermoelectric device and a cycle includes ramping to a first desired temperature or heat flux, maintaining the first desired temperature or heat flux for a period of time, and then ramping to a second desired temperature or heat flux and holding the second desired temperature or heat flux for a second period of time,

wherein the temperature control system further comprises a temperature feedback sensor, wherein said controller is configured to generate a first electrical control signal to activate said thermoelectric device and said first electrical control signal is generated in response to a first value of the electrical characteristic of the thermoelectric device, wherein the electrical characteristic of the thermoelectric device comprises an electrical characteristic of the thermoelectric device indicating one of a temperature gradient across the thermoelectric device and a temperature of the temperature controlled medium.

25. The temperature control system of claim 24, wherein said controller is configured to maintain a stable temperature of the temperature controlled medium.

26. The temperature control system of claim 24, wherein said controller is configured to cyclically alter the temperature profile of the temperature controlled medium.

27. The temperature control system of claim 24, wherein said controller is configured to provide a temperature ramp for the temperature controlled medium.

28. The temperature control system of claim 24, wherein said controller is configured to cool the tissue adjacent to said temperature controlled medium between about 1 and about 20 degrees Centigrade.

29. The temperature control system of claim 24, wherein said controller is configured to heat the tissue adjacent to said temperature controlled medium between about 1 and about 20 degrees Centigrade.

30. The temperature control system of claim 24, wherein said medical instrument is configured to be insertable into an ear canal of a subject.

31. The temperature control system of claim 24, wherein said medical instrument is a vestibular system stimulator.

32. The temperature control system of claim 31, wherein said vestibular system stimulator is configured to deliver caloric vestibular stimulation.

33. The temperature control system of claim 24, wherein said medical instrument is a nerve stimulation probe.

34. The temperature control system of claim 33, wherein said nerve stimulation probe is a vagal nerve stimulation probe.

35. A method of treating a subject, comprising:

positioning the temperature controlled medium of claim 24 in an ear canal of a subject; and

activating the thermoelectric device of claim 24 sufficient to treat the subject.

36. A method of delivering caloric vestibular stimulation to a subject, comprising:

positioning the temperature controlled medium of claim 24 in an ear canal of a subject; and

activating the thermoelectric device of claim 24 to deliver caloric vestibular stimulation to the subject.

37. A method of stimulating a nerve in a subject in need thereof, comprising:

positioning the temperature controlled medium of claim 24 in an ear canal of a subject; and

activating the thermoelectric device of claim 24 to stimulate the nerve.

38. A method of reducing pain in a subject, comprising:

positioning the temperature controlled medium of claim 24 in an ear canal of a subject; and

activating the thermoelectric device of claim 24 to treat migraine headache pain.

39. The temperature control system of claim 24, wherein the controller is configured to cyclically activate the thermoelectric device with each cycle lasting from about one minute to about ten minutes in duration.

40. A temperature control system comprising:

a thermoelectric device;

a controller electrically coupled to the thermoelectric device;

a heat transfer structure thermally coupled to a first side of the thermoelectric device; and

a temperature controlled medium thermally coupled to a second side of the thermoelectric device so that the thermoelectric device is thermally coupled between the heat transfer structure and the temperature controlled medium, wherein said temperature controlled medium comprises a medical instrument configured to contact living tissue,

wherein said controller is configured to cyclically alter the temperature profile of the temperature controlled medium, and a temperature profile cycle includes ramping to a first desired temperature or heat flux, maintaining the first desired temperature or heat flux for a period of time, and then ramping to a second desired temperature or heat flux and holding the second desired temperature or heat flux for a second period of time,

wherein the temperature control system further comprises a temperature feedback sensor, wherein said controller is configured to generate a first electrical control signal to activate said thermoelectric device and said first electrical control signal is generated in response to a first value of the electrical characteristic of the thermoelectric device, wherein the electrical characteristic of the thermoelectric device comprises an electrical characteristic of the thermoelectric device indicating one of a temperature gradient across the thermoelectric device and a temperature of the temperature controlled medium.

41. The temperature control system of claim 40, wherein said controller is configured to maintain a stable temperature of the temperature controlled medium.

42. The temperature control system of claim 41, wherein said medical instrument is a nerve stimulation probe.

43. The temperature control system of claim 42, wherein said nerve stimulation probe is a vagal nerve stimulation probe.

44. The temperature control system of claim 40, wherein said controller is configured to cyclically alter the temperature profile of the temperature controlled medium.

45. The temperature control system of claim 40, wherein said controller is configured to provide a temperature ramp for the temperature controlled medium.

46. The temperature control system of claim 40, wherein said controller is configured to cool the tissue adjacent to said temperature controlled medium between about 1 and about 20 degrees Centigrade.

47. The temperature control system of claim 40, wherein said controller is configured to heat the tissue adjacent to said temperature controlled medium between about 1 and about 20 degrees Centigrade.

48. The temperature control system of claim 40, wherein said medical instrument is configured to be insertable into an ear canal of a subject.

49. The temperature control system of claim 40, wherein said medical instrument is a vestibular system stimulator.

50. The temperature control system of claim 49, wherein said vestibular system stimulator is configured to deliver caloric vestibular stimulation.

51. A method of treating a subject, comprising:

positioning the temperature controlled medium of claim 40 in the ear canal of a subject; and

activating the thermoelectric device of claim 40 sufficient to treat the subject.

52. A method of delivering caloric vestibular stimulation to a subject, comprising:

positioning the temperature controlled medium of claim 40 in the ear canal of a subject; and

activating the thermoelectric device of claim 40 to deliver caloric vestibular stimulation to the subject.

53. A method of stimulating a nerve in a subject in need thereof, comprising:

positioning the temperature controlled medium of claim 40 in an ear canal of a subject; and

activating the thermoelectric device of claim 40 to stimulate the nerve.

54. A method of reducing pain in a subject, comprising:

positioning the temperature controlled medium of claim 40 in the ear canal of a subject; and

activating the thermoelectric device of claim 40 to treat migraine headache pain.

55. The temperature control system of claim 40, wherein the controller is configured to cyclically alter the temperature profile of the temperature controlled medium with each cycle lasting from about one minute to about ten minutes in duration.