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Methods for the treatment of mast cell related disorders with mast cell stabilizers

  • US 10,391,078 B2
  • Filed: 02/20/2019
  • Issued: 08/27/2019
  • Est. Priority Date: 08/07/2015
  • Status: Active Grant
First Claim
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1. A method of treating a subject having a mast cell related disorder, comprising administering to the subject an effective amount of a composition comprising cromolyn, or a salt thereof, using an inhalation device that produces in the subject an AUC(0-∞

  • ) of cromolyn of from about 5.3 ng*h/mL to about 8.5 ng*h/mL per milligram of cromolyn, or a salt thereof, administered to the subject, and wherein the mast cell related disorder is selected from primary biliary cirrhosis, secondary sclerosing cholangitis due to mast cell cholangiopathy, itching caused by or associated with primary biliary cirrhosis, bronchiolitis obliterans syndrome after lung transplantation, bronchopulmonary dysplasia in infants, cardiac fibrosis, atrial fibrosis, primary sclerosing cholangitis (PSC), chronic pelvic pain syndrome (prostatitis), viral pneumonia caused by respiratory syncytial virus, and interstitial lung disease.

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