Autoinjector

• US 10,391,246 B2
• Filed: 11/04/2013
• Issued: 08/27/2019
• Est. Priority Date: 11/06/2012
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: Henderson, Charley, Cross, David, Jennings, Douglas Ivan, McGinley, Ryan Anthony
• Primary Examiner(s): Farrar, Lauren P
• Application Number:
  US14/440,819
• Publication Number:
  US 20150297833A1
• Time in Patent Office: 2,122 Days
• CPC Class Codes: A61M 2005/202 cocking means, e.g. to bias the main drive spring of an injector
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/208 Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin
• CPC Class Codes: A61M 2005/314 Flat shaped barrel forms, e.g. credit card shaped
• CPC Class Codes: A61M 2005/3247 Means to impede repositioning of protection sleeve from needle covering to needle uncovering position
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/582 by tactile feedback
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 2205/586 Ergonomic details therefor, e.g. specific ergonomics for left or right-handed users
• CPC Class Codes: A61M 2205/60 with identification means
• CPC Class Codes: A61M 2205/6009 for matching patient with his treatment, e.g. to improve transfusion security
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/3129 Syringe barrels A61M5/3205 and A61M5/50 take precedence
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: A61M 5/3204 Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
• CPC Class Codes: A61M 5/3245 Constructional features thereof, e.g. to improve manipulation or functioning
• CPC Class Codes: A61M 5/326 Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
• CPC Class Codes: A61M 5/46 having means for controlling depth of insertion

Abstract

Described is an autoinjector comprising a case, a door hingedly coupled to the case and having an open position and a closed position, a plunger slidably disposed in the case, and at least one drive spring applying a biasing force on the plunger relative to the case, wherein the door is operably coupled to the plunger, and wherein rotation of the door from the closed position to the open position moves the plunger from a distal position in the case to a proximal position in the case and compresses the at least one drive spring.

Claims

1. An autoinjector comprising:

a syringe comprising a body and a needle carried by the body, the syringe being movable to advance the needle for insertion along a needle insertion direction;

a case configured to receive the syringe;

a door hingedly coupled to the case and having an open position and a closed position;

a plunger slidably disposed in the case; and

two parallel compression drive springs disposed on opposite sides of the syringe and positioned between a proximal end of the case and a distal end of the plunger, the two parallel compression drive springs respectively defining two axes along which the two parallel compression drive springs are compressible and that are parallel to the needle insertion direction, the two parallel compression drive springs configured to apply a biasing force on the plunger relative to the case, and the plunger being configured to advance the syringe relative to the case and to advance a stopper of the syringe relative to the body of the syringe when the two parallel compression drive springs apply the biasing force on the plunger,

wherein the door is operably coupled to the plunger in a manner such that rotation of the door from the closed position to the open position moves the plunger from a distal position in the case to a proximal position in the case and compresses the two parallel compression drive springs.

2. The autoinjector of claim 1, further comprising:

a trigger button disposed on the case and operably coupled to the plunger.

3. The autoinjector of claim 2, further comprising:

an interlock sleeve slidably disposed in the case and having an extended position and a retracted position relative to the case.

4. The autoinjector of claim 3, wherein the interlock sleeve comprises at least one interlock beam extending axially in the case.

5. The autoinjector of claim 4, further comprising:

at least one resilient button locking beam disposed in the case and configured to engage the at least one interlock beam.

6. The autoinjector of claim 5, wherein the at least one interlock beam is configured to cause the at least one resilient button locking beam to deflect when the interlock sleeve is in the retracted position.

7. The autoinjector of claim 6, further comprising:

at least one trigger button beam operably coupled to the trigger button, wherein the at least one trigger button beam is configured to abut the at least one resilient button locking beam when the interlock sleeve is in the extended position.

8. The autoinjector of claim 1, wherein the plunger comprises:

a transverse beam,

a piston rod extending longitudinally from the transverse beam and configured to advance along the longitudinal axis to engage the stopper of the syringe, and

at least one leg extending from the transverse beam and parallel to the piston rod, the at least one leg comprising a distal foot and a ratchet face having a plurality of teeth, the distal foot being configured to support at least one of the two parallel compression drive springs.

9. The autoinjector of claim 8, further comprising:

at least one resilient tongue disposed in the case and having a hook configured to engage a tooth of the plurality of teeth.

10. The autoinjector of claim 9, further comprising:

a trigger button; and

at least one trigger button beam disposed in the case, wherein the at least one trigger button beam is configured to cause the at least one tongue from the ratchet face to disengage from the tooth when the trigger button is actuated.

11. The autoinjector of claim 1, further comprising:

at least one lever hingedly coupled to the door; and

at least one roller rotatably coupled to the lever.

12. The autoinjector of claim 11, wherein the at least one roller is disposed in a track formed in the case.

13. The autoinjector of claim 1, further comprising:

a retraction collar configured to engage a needle boot on a syringe.

14. The autoinjector of claim 13, further comprising at least one lever hingedly coupled to the door, wherein the at least one lever is configured to engage the retraction collar to push the needle boot at least partially through an aperture of an interlock sleeve slidably disposed in the case when the door is rotated from the open position to the closed position.

15. A method of delivering a medicament, the method comprising:

placing a syringe containing the medicament into a case of an autoinjector, the syringe comprising a body, comprising a needle carried by the body, and being movable to advance the needle for insertion along a needle insertion direction;

closing a door of the autoinjector to compress two parallel compression drive springs of the autoinjector, the two parallel compression drive springs being disposed on opposite sides of the syringe, being positioned between a proximal end of the case and a distal end of a plunger of the autoinjector, and the two parallel compression drive springs respectively defining two axes along which the two parallel compression drive springs are compressible and that are parallel to the needle insertion direction; and

releasing the two parallel compression drive springs of the autoinjector to advance the plunger such that the syringe is advanced relative to the case of the autoinjector and a stopper of the syringe is advanced relative to the body of the syringe, thereby delivering the medicament to a patient through an injection site on the patient.

16. The method of claim 15, further comprising:

removing the autoinjector from the injection site;

opening the door of the autoinjector; and

after opening the door of the autoinjector, removing the syringe from the case.

17. The method of claim 16, wherein:

opening the door of the autoinjector moves the plunger in a proximal direction, and

delivering the medicament to the patient comprises advancing the plunger in a distal direction to advance the syringe and to advance the stopper.

18. The method of claim 17, wherein opening the door prevents the plunger from advancing in the distal direction.

19. The method of claim 16, wherein closing the door of the autoinjector at least partially disengages a needle boot of the syringe from a needle of the syringe.

20. The method of claim 16, wherein closing and opening the door of the autoinjector comprises hingedly rotating the door relative to the case of the autoinjector.

21. The method of claim 15, wherein delivering the medicament comprises:

placing the autoinjector against an injection site of a patient to unlock a trigger button of the autoinjector; and

pressing the trigger button of the autoinjector to release the two parallel compression drive springs.

22. An autoinjector comprising:

a case configured to receive a syringe;

a door hingedly coupled to the case and having an open position and a closed position;

a plunger slidably disposed in the case; and

two compression drive springs positioned between a proximal end of the case and a distal end of the plunger, the two compression drive springs being parallel to each other and disposed on opposite sides of the syringe, the two compression drive springs configured to apply a biasing force on the plunger relative to the case, and the plunger being configured to advance the syringe relative to the case and to advance a stopper of the syringe relative to a body of the syringe when the two compression drive springs apply the biasing force on the plunger,

wherein the door is operably coupled to the plunger in a manner such that rotation of the door from the closed position to the open position moves the plunger from a distal position in the case to a proximal position in the case and compresses the two compression drive springs.