Setting mechanism

• US 10,391,258 B2
• Filed: 04/13/2018
• Issued: 08/27/2019
• Est. Priority Date: 10/15/2015
• Status: Active Grant

• Current Assignee: Nemera Szczecin Spolka Z Ograniczona Odpowiedzialnoscia
• Original Assignee: Copernicus Sp. Z o.o.
• Inventors: Stefanski, Adam, Wilczek, Mateusz, Lozano Platonoff, Alberto
• Primary Examiner(s): Bouchelle, Laura A
• Assistant Examiner(s): Ulsh, Dung T
• Application Number:
  US15/952,475
• Publication Number:
  US 20180228981A1
• Time in Patent Office: 501 Days
• CPC Class Codes: A61M 2005/3126 Specific display means related to dosing
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/31535 Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
• CPC Class Codes: A61M 5/31538 Permanent blocking, e.g. by medical personnel
• CPC Class Codes: A61M 5/31553 without axial movement of dose setting member
• CPC Class Codes: A61M 5/31583 based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
• CPC Class Codes: A61M 5/31585 performed by axially moving actuator, e.g. an injection button

Abstract

A setting mechanism for a dosing device, in particular for a device for dosing pharmaceutical or therapeutic substances, the setting mechanism including: a controlling assembly for connecting the setting mechanism with a dose setting element of the dosing device; a driving assembly for connecting the setting mechanism with a driving element of the dosing device; a dosing assembly for connecting the setting mechanism with a dosing element of the dosing device. The controlling assembly is coupled with the dosing assembly by a spring element, which can deform from a coupled position to a decoupled position during rotation of the dose setting element. The spring element is configured to allow a displacement of the controlling assembly with respect to the dosing assembly. In the coupled position the spring element is configured to block a rotation of the controlling assembly with respect to the dosing assembly.

Claims

1. An applicator comprising:

a housing comprising an inspection opening,

a dose setting knob coupled to the housing,

a setting mechanism coupled by a connecting element to the dose setting knob,

at least two coil springs comprising a driving coil spring extending in an axial direction,

a non-rotatable lock connected to the housing and to the driving coil spring,

a rotatable driving sleeve connected to the driving coil spring,

an indicating sleeve connected movably with the rotatable driving sleeve,

wherein the indicating sleeve is mounted slidingly and co-axially on the rotatable driving sleeve by a spline coupling comprising longitudinal protrusions,

wherein the housing comprises a first end portion with a first external diameter and a second end portion with a second external diameter, the second external diameter being greater than the first external diameter,

wherein the dose setting knob is rotatable and comprises at least one protrusion to couple with the first end portion of the housing,

wherein the connecting element comprises a longitudinal sleeve and extends above the first end portion of the housing to couple with the dose setting knob,

wherein the first end portion of the housing comprises at least two openings arranged non-coaxially,

wherein the non-rotatable lock comprises a curved surface to cover at least a portion of the at least two openings of the first end portion of the housing,

wherein the non-rotatable lock comprises a through-bore to receive the longitudinal sleeve of the connecting element, an opening to attach the driving coil spring and a wall to separate at least partially the through-bore from the opening,

wherein the wall of the non-rotatable lock covers at least a portion of the longitudinal sleeve of the connecting element,

wherein the longitudinal sleeve of the connecting element comprises a first end portion comprising protrusions and a second end portion to receive at least a portion of a piston rod,

wherein the piston rod is coupled to the driving coil spring, the driving coil spring being configured to drive the piston rod,

wherein the dose setting knob covers at least a portion of the wall of the non-rotatable lock, the curved surface of the non-rotatable lock, the first end portion of the housing and the protrusions of the first end portion of the longitudinal sleeve of the connecting element,

wherein the dose setting knob, the housing, the non-rotatable lock, the driving sleeve, the indicating sleeve, the driving coil spring, the connecting element and the piston rod are arranged coaxially.

2. The applicator according to claim 1, wherein the longitudinal sleeve of the connecting element comprises an internal waist.

3. The applicator according to claim 1, wherein the at least one protrusion of the dose setting knob axially blocks the dose setting knob to prevent the dose setting knob from moving in the axial direction.

4. The applicator according to claim 1, wherein the dose setting knob comprises at least one through-bore comprising a first opening and a second opening.

5. The applicator according to claim 4, wherein the dose setting knob comprises a covering element, wherein the covering element covers at least the first opening of the at least one through-bore of the dose setting knob, wherein the covering element comprises at least one protrusion and a concave portion.

6. The applicator according to claim 1, wherein the the applicator comprises the indicating sleeve and a cartridge holder, wherein only one of the indicating sleeve and the cartridge holder comprises a scale.

7. The applicator according to claim 1, wherein the the applicator comprises a cartridge holder, wherein the cartridge holder comprises an opening window, wherein the opening window comprises opposite edges, wherein the opposite edges are symmetrically shaped in respect to a main axis of the applicator.

8. The applicator according to claim 1, wherein the housing comprises at least five openings.

9. The applicator according to claim 1, wherein the dose setting knob, the connecting element, the driving sleeve, the indicating sleeve and the driving coil spring are rotatable.

10. The applicator according to claim 1, wherein the spline coupling ensures a play between an outer cylinder of the driving sleeve and an inner cylindrical wall of the indicating sleeve.

11. The applicator according to claim 1, wherein the piston rod is coupled to a piston rod guide and a nut.

12. The applicator according to claim 6, wherein the cartridge holder comprises an external surface, a first portion, a second portion and a third portion, wherein the first portion of the cartridge holder is adapted to connect with a needle, the second portion of the cartridge holder comprises an opening window and the third portion of the cartridge holder is adapted to connect with the housing, wherein only one of the first portion of the cartridge holder and the second portion of the cartridge holder comprises grooves on the external surface.

13. The applicator according to claim 1, wherein the indicating sleeve covers at least a portion of the rotatable driving sleeve, the rotatable driving sleeve covers at least a portion of the driving coil spring, and the driving coil spring covers at least a portion of the connecting element.

14. The applicator according to claim 1, wherein the setting mechanism comprises a controlling assembly for connecting the setting mechanism with the dose setting knob, a driving assembly for connecting the setting mechanism with the spring element, a dosing assembly for connecting the setting mechanism with the piston rod, wherein the piston rod is connected to a nut, wherein the piston rod or the nut is rotatable.

15. The applicator according to claim 1, wherein the inspection window is at least partially surrounded by an indentation portion of the housing, wherein the indentation portion comprises at least two protrusions.

16. The applicator according to claim 1, wherein the applicator comprises a cap, wherein the cap comprises a proximal portion and a distal portion, wherein the proximal portion comprises an external surface, wherein the cap comprises at least three hollow portions on the external surface of the proximal portion.

17. The applicator according to claim 1, wherein the applicator is adapted to provide a substantially constant time of injection for a particular dose.

18. The applicator according to claim 1, wherein the applicator is adapted to administer GLP-1, wherein the applicator is adapted to hold a 1.5 mL cartridge.

19. The applicator according to claim 1, wherein the applicator is an injecting device for liquid preparations, wherein an injection force of the applicator does not exceed 10 N.

20. The applicator according to claim 1, wherein the applicator is a delivery device adapted to inject 20 IU within a range from 0.9 seconds to 1.8 seconds.