Methods and devices for activating brown adipose tissue using electrical energy

• US 10,391,298 B2
• Filed: 11/21/2018
• Issued: 08/27/2019
• Est. Priority Date: 12/29/2014
• Status: Active Grant

• Current Assignee: Cilag Gmbh International (Johnson & Johnson)
• Original Assignee: Ethicon, LLC (Johnson & Johnson)
• Inventors: Harris, Jason L., Baynham, Tamara C.
• Primary Examiner(s): Mahmood, Nadia A
• Application Number:
  US16/197,786
• Publication Number:
  US 20190091464A1
• Time in Patent Office: 279 Days
• Field of Search: 607 2, 607116
• CPC Class Codes: A61N 1/0456 Specially adapted for transcutaneous electrical nerve stimulation [TENS]
• CPC Class Codes: A61N 1/0492 Patch electrodes A61N1/0412, A61N1/0428 take precedence
• CPC Class Codes: A61N 1/0502 Skin piercing electrodes
• CPC Class Codes: A61N 1/0504 Subcutaneous electrodes
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36034 specified by the stimulation parameters
• CPC Class Codes: A61N 1/36146 specified by the stimulation parameters
• CPC Class Codes: A61N 1/36189 using modulation techniques

Abstract

Methods and devices are provided for activating brown adipose tissue (BAT) using electrical energy. In general, the methods and devices can facilitate activation of BAT to increase thermogenesis. The BAT can be activated by applying an electrical signal thereto that can be configured to target sympathetic nerves that can directly innervate the BAT. The electrical signal can be configured to target the sympathetic nerves using fiber diameter selectivity. In other words, the electrical signal can be configured to activate nerve fibers having a first diameter without activating nerve fibers having diameters different than the first diameter. Sympathetic nerves include postganglionic unmyelinated, small diameter fibers, while parasympathetic nerves that can directly innervate BAT include preganglionic myelinated, larger diameter fibers. The electrical signal can be configured to target and activate the postganglionic unmyelinated, small diameter fibers without activating the preganglionic myelinated, larger diameter fibers.

Claims

1. A medical apparatus, comprising:

a device configured to be positioned in contact with tissue of a patient and configured to be activated, when so positioned, to deliver an electrical signal to the patient using an electrode of the device and thereby activate a first type of neurons in brown adipose tissue (BAT) of the patient without activating a second, different type of neurons in the BAT.

2. The apparatus of claim 1, wherein the first type of neurons are unmyelinated neurons, and the second type of neurons are myelinated neurons.

3. The apparatus of claim 1, wherein the first type of neurons have a first diameter, and the second type of neurons have a second diameter that is greater than the first diameter.

4. The apparatus of claim 1, wherein the electrical signal has a peak current that is in a range of about 50 mA to 100 mA.

5. The apparatus of claim 1, wherein the device is configured to be positioned in contact with tissue of the patient by being transcutaneously applied to an exterior skin surface of the patient.

6. The apparatus of claim 1, wherein the device is configured to be positioned in contact with tissue of the patient by being partially positioned within the patient.

7. The apparatus of claim 1, wherein the device is configured to be positioned in contact with tissue of the patient by being implanted entirely within the patient.

8. A medical method, comprising:

identifying a depot of brown adipose tissue (BAT) of a patient;

securing an electrode to the patient; and

causing the electrode to deliver an electrical signal to the patient and thereby activate a first nerve type in the BAT without activating a second, different nerve type in the BAT, the first nerve type having a smaller diameter than the second nerve type.

9. The method of claim 8, further comprising generating, using a signal generator operatively coupled to the electrode, the electrical signal to be delivered to the patient, wherein the signal generator is one of:

located outside of the patient, and

implanted within the patient.

10. The method of claim 9, wherein the signal generator continuously generates the electrical signal for a period of time such that the electrical signal is continuously delivered to the patient throughout the period of time.

11. The method of claim 9, wherein the signal generator intermittently generates the electrical signal for a period of time such that the electrical signal is intermittently delivered to the patient during the period of time.

12. The method of claim 8, wherein securing the electrode comprises one of:

implanting the electrode within the patient such that the electrode directly contacts at least one of the BAT, the first nerve type, and the second nerve type, and applying the electrode entirely external to the patient.

13. The method of claim 8, wherein the first nerve type includes sympathetic nerves, and the second nerve type includes parasympathetic nerves.

14. The method of claim 8, wherein the first nerve type includes sympathetic nerves, and the second nerve type includes sensory nerves.

15. The method of claim 8, wherein the first nerve type includes unmyelinated neurons, and the second nerve type includes myelinated neurons.

16. A medical method, comprising:

positioning an electrode in contact with tissue of a patient;

generating an electrical signal using a signal generator; and

causing the electrode to deliver the electrical signal to the patient so as to activate a first nerve type in brown adipose tissue (BAT) without activating a second, different nerve type in the BAT, the first nerve type having a smaller diameter than the second nerve type.

17. The method of claim 16, wherein the first nerve type includes sympathetic nerves, and the second nerve type includes parasympathetic nerves.

18. The method of claim 16, wherein the first nerve type includes sympathetic nerves, and the second nerve type includes sensory nerves.

19. The method of claim 16, wherein the first nerve type includes unmyelinated neurons, and the second nerve type includes myelinated neurons.

20. The method of claim 16, wherein positioning the electrode comprises one of:

implanting the electrode within the patient such that the electrode directly contacts at least one of the BAT, the first nerve type, and the second nerve type, and

applying the electrode entirely external to the patient.