System for selective spatiotemporal stimulation of the spinal cord

• US 10,391,309 B2
• Filed: 12/21/2016
• Issued: 08/27/2019
• Est. Priority Date: 12/22/2015
• Status: Active Grant

• Current Assignee: Ecole polytechnique fãdãrale de lausanne epfl (Schweizerische Eidgenossenschaft)
• Original Assignee: Ecole polytechnique fãdãrale de lausanne epfl (Schweizerische Eidgenossenschaft)
• Inventors: Bloch, Jocelyne, Courtine, Gregoire, Wenger, Nikolaus, Micera, Silvestro, Capogrosso, Marco
• Primary Examiner(s): Wehrheim, Lindsey G
• Application Number:
  US15/387,531
• Publication Number:
  US 20170173326A1
• Time in Patent Office: 979 Days
• CPC Class Codes: A61B 5/389 Electromyography [EMG]
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61N 1/0553 Paddle shaped electrodes, e.g. for laminotomy
• CPC Class Codes: A61N 1/36003 of motor muscles, e.g. for walking assistance
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36139 with automatic adjustment

Abstract

The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.

Claims

1. A system for spatiotemporal electrical neurostimulation of a spinal cord of a subject, comprising:

a signal processing device configured to receive signals from said subject and operate signal-processing algorithms to determine stimulation parameter settings;

one or more multi-electrode arrays configured to cover a portion of the spinal cord of said subject and apply selective spatiotemporal stimulation of spinal circuits and/or dorsal roots of the subject; and

an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from said signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multi-electrode arrays;

wherein said IPG is operatively connected with the signal processing device and the one or more multi-electrode arrays to provide a multipolar stimulation, where the multipolar stimulation directs a stimulation field to a desired anatomical location by modulating a shape of the stimulating field to enhance a spatial specificity of the electrical neuro stimulation; and

wherein the system is configured and arranged to collect information about locomotor intention of the subject and decode this information by means of the signal processing device.

2. The system of claim 1, wherein said signals from the subject include one or more of neural signals, signals providing features of motion of said subject, kinematic signals, and electromyography signals.

3. The system of claim 1, wherein said IPG comprises a neutral returning electrode as reference.

4. The system of claim 1, wherein said signal processing device is included in said IPG.

5. The system of claim 1, wherein said one or more multi-electrode arrays is placed epidurally or subdurally in the spinal cord of said subject.

6. The system of claim 1, further comprising an apparatus for restoring control of neuromotor function to a subject suffering from a neuromotor impairment.

7. The system of claim 6, wherein said neuromotor impairment includes at least one of partial paralysis of limbs, total paralysis of limbs, immunological impairment, and loss of organ function.

8. The system of claim 6, wherein the apparatus comprises at least one of a treadmill, an exoskeleton, a robot-assisted body-weight support, and a multidirectional trunk support system.

9. The system of claim 6, wherein the apparatus is for use in a method for restoring voluntary control of locomotion in the subject suffering from the neuromotor impairment.

10. The system of claim 1, wherein the decoding is done by using machine-learning approaches.

11. The system of claim 1, wherein the system is a system for neuromotor impairment.

12. The system of claim 11, wherein the neuromotor impairment is a consequence of at least one of a spinal cord injury (SCI), an ischemic injury resulting from a stroke, or a neurodegenerative disease including Parkinson'"'"'s disease.

13. A system for electrical neurostimulation of a spinal cord of a subject, comprising:

a pulse generator configured to simultaneously deliver independent current or voltage pulses to multiple electrodes; and

one or more multi-electrode arrays configured to cover a portion of the spinal cord to selectively stimulate spinal circuits and/or dorsal roots, wherein said pulse generator is operatively connected with said one or more multi-electrode arrays to provide a multipolar stimulation that directs a stimulation field to a desired anatomical location by modulating a shape of the stimulating field to enhance a spatial specificity of the electrical neurostimulation; and

wherein the system is configured and arranged to collect information about locomotor intention of the subject and decode this information by means of a signal processing device.

14. The system of claim 13, wherein the pulse generator is an Implanted Pulse Generator (IPG).

15. The system of claim 13, wherein a casing of said pulse generator is set as a neutral referencing ground.

16. The system of claim 13, wherein said one or more multi-electrode arrays is placed epidurally or subdurally in the spinal cord of said subject.

17. The system of claim 13, wherein said one or more multi-electrode arrays includes at least one portion comprising electrodes arranged in a transverse direction relative to the spinal cord and at least one portion comprising electrodes arranged in a longitudinal direction relative to the spinal cord.

18. The system of claim 13, wherein said one or more multi-electrode arrays comprises multiple electrodes arranged in two or more columns disposed in a longitudinal direction relative to the spinal cord.

19. The system of claim 13, wherein the decoding is done by using machine-learning approaches.

20. The system of claim 13, wherein the system is a system for neuromotor impairment.

21. The system of claim 20, wherein the neuromotor impairment is a consequence of at least one of a spinal cord injury (SCI), an ischemic injury resulting from a stroke, or a neurodegenerative disease, such as Parkinson'"'"'s disease.

22. A closed-loop system for electrical neurostimulation of a spinal cord of a subject for a fine control of movement comprising:

a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, operatively connected with

a signal processing device configured to receive said feedback signals and operate real-time automatic control algorithms to determine electrical stimulation parameter settings, operatively connected with

an Implantable Pulse Generator (IPG) configured to receive said stimulation parameter settings from said signal processing device and simultaneously deliver independent current or voltage pulses to multiple electrodes, operatively connected with

one or more multi-electrode arrays configured to cover a portion of the spinal cord and apply a selective stimulation of spinal circuits and/or dorsal roots of the subject, wherein said IPG provides said one or more multi-electrode arrays with a multipolar stimulation that directs a stimulation field to a desired anatomical location by modulating a shape of the stimulating field to enhance a spatial specificity of the electrical neurostimulation; and

wherein the closed-loop system is configured and arranged to collect information about locomotor intention of the subject and decode this information by means of the signal processing device.

23. The system of claim 22, wherein said one or more multi-electrode arrays includes at least one portion comprising electrodes arranged in a transverse direction relative to the spinal cord and at least one portion comprising electrodes arranged in a longitudinal direction relative to the spinal cord.

24. The system of claim 22, wherein said one or more multi-electrode arrays comprises multiple electrodes arranged in two or more columns disposed in a longitudinal direction relative to the spinal cord.

25. The system of claim 22, wherein the signal processing device is configured to execute a method for restoring voluntary control of locomotion in a subject suffering from a neuromotor impairment.

26. The system of claim 22, further comprising an apparatus for restoring voluntary control of locomotion to a subject suffering from a neuromotor impairment.

27. The system of claim 26, wherein the apparatus comprises at least one of a treadmill, an exoskeleton, a robot-assisted body-weight support, and a multidirectional trunk support system.

28. The system of claim 22, wherein the decoding is done by using machine-learning approaches.

29. The system of claim 22, wherein the system is a system for neuromotor impairment.

30. The system of claim 29, wherein the neuromotor impairment is a consequence of at least one of a spinal cord injury (SCI), an ischemic injury resulting from a stroke, or a neurodegenerative disease, such as Parkinson'"'"'s disease.