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Adaptive background detection and signal quantification systems and methods

  • US 10,395,350 B2
  • Filed: 02/26/2018
  • Issued: 08/27/2019
  • Est. Priority Date: 07/26/2013
  • Status: Expired due to Fees
First Claim
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1. A processor-implemented method of processing image data of an image to determine a signal quantification value for a signal of interest in the image data, the method comprising:

  • identifying a first region of the image, the first region including a plurality of pixels, each pixel having a pixel intensity value, said first region including the signal of interest and a background signal component;

    determining, using the image data, a total number of discrete pixel intensity values for the plurality of pixels in the first region;

    calculating, for each discrete pixel intensity value, a total number of the pixels in the first region having that discrete pixel intensity value;

    determining a mean value of the background signal component based on the total number of pixels for each discrete pixel intensity value;

    validating a distribution of the background signal component in the first region;

    calculating a signal quantification value for the signal of interest, wherein the signal quantification value represents the signal of interest with the background signal component removed; and

    displaying the signal quantification value on an output device.

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