Methods and apparatus for determining pulse transit time as a function of blood pressure
First Claim
1. A method for determining pulse transit time as a function of blood pressure for a subject, comprising:
- measuring a proximal waveform indicative of an arterial pulse at a proximal site of the subject using a first sensor;
measuring a distal waveform indicative of the arterial pulse at a distal site of the subject using a second sensor;
defining a relationship between the proximal waveform and the distal waveform in terms of unknown parameters of a nonlinear model, where the nonlinear model accounts for wave propagation and reflection and accounts for arterial compliance that depends on blood pressure, and where the unknown parameters define a function relating pulse transit time and blood pressure;
determining the unknown parameters of the nonlinear model from the measured proximal waveform and the measured distal waveform; and
determining pulse transit time as a function of blood pressure using the parameters of the nonlinear model, where the steps of determining the unknown parameters of the nonlinear model and determining pulse transit time are implemented by a computer processor of a computing device.
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Accused Products
Abstract
A method is provided for determining pulse transit time of a subject as a function of blood pressure. The method includes: measuring a proximal waveform indicative of the arterial pulse at a proximal site of the subject; measuring a distal waveform indicative of the arterial pulse at a distal site of the subject; defining a relationship between the proximal waveform and the distal waveform in terms of unknown parameters of a nonlinear model; determining the unknown parameters of the nonlinear model from the measured proximal waveform and the measured distal waveform; and determining pulse transit time for the subject as a function of blood pressure from the parameters of the nonlinear model. The nonlinear model can account for arterial compliance and peripheral wave reflection, where the arterial compliance depends on blood pressure.
13 Citations
18 Claims
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1. A method for determining pulse transit time as a function of blood pressure for a subject, comprising:
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measuring a proximal waveform indicative of an arterial pulse at a proximal site of the subject using a first sensor; measuring a distal waveform indicative of the arterial pulse at a distal site of the subject using a second sensor; defining a relationship between the proximal waveform and the distal waveform in terms of unknown parameters of a nonlinear model, where the nonlinear model accounts for wave propagation and reflection and accounts for arterial compliance that depends on blood pressure, and where the unknown parameters define a function relating pulse transit time and blood pressure; determining the unknown parameters of the nonlinear model from the measured proximal waveform and the measured distal waveform; and determining pulse transit time as a function of blood pressure using the parameters of the nonlinear model, where the steps of determining the unknown parameters of the nonlinear model and determining pulse transit time are implemented by a computer processor of a computing device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for determining pulse transit time as a function of blood pressure for a subject, comprising:
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measuring a proximal waveform indicative of blood pressure at a proximal site of the subject using a first sensor; measuring a distal waveform indicative of blood pressure at a distal site of the subject using a second sensor; defining a relationship between the proximal waveform and the distal waveform in terms of unknown parameters of a nonlinear tube-load model, wherein the nonlinear tube-load model accounts for wave propagation and arterial compliance that depends on blood pressure; determining the unknown parameters of the nonlinear model from the measured proximal waveform and the measured distal waveform; and determining pulse transit time as a function of blood pressure from the determined parameters of the nonlinear tube-load model, where the steps of determining the unknown parameters of the nonlinear model and determining pulse transit time are implemented by a computer processor of a computing device. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
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18. A method for determining pulse transit time as a function of blood pressure for a subject, comprising:
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measuring a proximal waveform indicative of an arterial pulse at a proximal site of the subject using a first sensor; measuring a distal waveform indicative of the arterial pulse at a distal site of the subject using a second sensor; defining a relationship between the proximal waveform and the distal waveform in terms of unknown parameters of a nonlinear model, wherein the nonlinear model accounts for wave propagation and arterial compliance that depends on blood pressure; determining the unknown parameters of the nonlinear model by fitting the measured proximal waveform to the measured distal waveform; and determining pulse transit time as a function of blood pressure from the parameters of the nonlinear model, where the steps of determining the unknown parameters of the nonlinear model and determining pulse transit time are implemented by a computer processor of a computing device.
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Specification