Methods and systems for providing a breathing rate calibrated to a resonance breathing frequency

• US 10,398,350 B2
• Filed: 06/12/2018
• Issued: 09/03/2019
• Est. Priority Date: 02/08/2016
• Status: Active Grant

• Current Assignee: Vardas Solutions, LLC
• Original Assignee: Vardas Solutions, LLC
• Inventors: Vardas, Chad, Jones, Alex
• Primary Examiner(s): Porter, Allen
• Application Number:
  US16/006,558
• Publication Number:
  US 20180289285A1
• Time in Patent Office: 448 Days
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/7242 using integration

Abstract

A target respiration rate is determined for a user where, when the user breathes at the target rate, the user'"'"'s vagal tone is improved, which provides a physiological benefit to the user, e.g., stress reduction without drug intervention. The user is directed to breathe at different rates while heart rate and breathing rate are measured. A value representative of vagal tone is generated from the measured heart and breathing rates for each directed breathing rate. The breathing rate that produced the lowest generated vagal tone value is determined to be the user'"'"'s target respiration rate.

Claims

1. A method for determining a first target respiration frequency for a user, the first target respiration frequency intended to improve a vagal tone of the user, the method comprising:

providing the user with a first indication to breathe at a pre-determined respiration frequency for each of a first plurality of time periods, each of the first plurality of time periods having a pre-determined respiration frequency that is unique among the pre-determined respiration frequencies for the first plurality;

using a first sensor, taking first measurements of the user for each of the first plurality of time periods;

determining, from the first measurements taken of the user, a first heart rate variability value for each of the first plurality of time periods;

using a second sensor, taking second measurements of the user for each of the first plurality of time periods;

determining, from the second measurements taken of the user and the first measurements, a first respiratory sinus arrhythmia value for each of the first plurality of time periods;

combining in whole or in part, for each of the first plurality of time periods, the first heart rate variability value and the first respiratory sinus arrhythmia value to create a first vagal tone value for each of the first plurality of time periods;

comparing the created plurality of first vagal tone values to each other to determine a first optimal vagal tone value; and

setting a first target respiration frequency based on a first respiration frequency from a time period corresponding to the first optimal vagal tone value, the first respiration frequency selected from the first pre-determined respiration frequency or a first actual respiration frequency.

2. The method of claim 1 further comprising:

determining, from the second measurements taken of the user, the first actual respiration frequency for each of the first plurality of time periods;

determining, based on a comparison of the first actual respiration frequency to the first pre-determined respiration frequency for each of the first plurality of time periods, a respiration correlation value for each of the first plurality of time periods, wherein;

the first vagal tone value is created by combining, for each of the first plurality of time periods, the first heart rate variability value, the first respiratory sinus arrhythmia value, and the respiration correlation value to create the first vagal tone value for each of the first plurality of time periods.

3. The method of claim 2, wherein the first respiration frequency from the time period corresponding to the first optimal vagal tone value is the actual respiration frequency for the time period corresponding to the first optimal vagal tone value.

4. The method of claim 1, wherein a time period of the first plurality of time periods has a first duration, the method further comprising:

providing to the user a second indication to breathe at a pre-determined respiration frequency for each of a second plurality of time periods, wherein;

each of the second plurality of time periods has a second duration less than the first duration,

each of the second plurality of time periods has a pre-determined respiration frequency that is unique among the pre-determined respiration frequencies for the second plurality, and

one of the second plurality of time periods has a pre-determined respiration frequency that is the first target respiration frequency;

determining, from third measurements taken of the user, a second heart rate variability value and, determining from the third measurements and from fourth measurements taken of the user a second respiratory sinus arrhythmia value for each of the second plurality time periods;

combining, in whole or in part, for each of the second plurality of time periods, the second heart rate variability and the second respiratory sinus arrhythmia value to create a second vagal tone value for each of the second plurality of time periods;

comparing the created plurality of second vagal tone values to each other to determine a second optimal vagal tone value; and

setting a second target respiration frequency based on a second respiration frequency from a time period corresponding to the second optimal vagal tone value, the second respiration frequency selected from the second pre-determined respiration frequency or a second actual respiration frequency.

5. The method of claim 4 further comprising:

providing to the user a third indication to breathe at the second target respiration frequency for each of a third plurality of time periods;

providing to the user, for each breath in each of the third plurality of time periods, an indication to pause breathing for a pre-determined pause duration after each inhalation and after each exhalation, wherein the second target respiration frequency is maintained, and wherein the pre-determined pause duration is different for each of the third plurality of time periods;

determining, from fifth measurements taken of the user, a third heart rate variability value and, determining from the fifth measurements and from sixth measurements taken of the user a third respiratory sinus arrhythmia value for each of the third plurality time periods;

combining, in whole or in part, for each of the third plurality of time periods, the third heart rate variability and the third respiratory sinus arrhythmia value to create a third vagal tone value for each of the third plurality of time periods;

comparing the created plurality of third vagal tone values to each other to determine a third optimal vagal tone value; and

modifying the second target respiration frequency to include a target pause between inhalation and exhalation, the target pause based on the pre-determined pause duration corresponding to the third optimal vagal tone value.

6. The method of claim 1, wherein the determining, from the first measurements taken of the user, a first heart rate variability value comprises:

determining, from the first measurements, peak valley differences in a heart rate of the user; and

scaling the determined peak valley differences to vary within a range of zero to one.

7. The method of claim 1, wherein the determining, from second measurements taken of the user and the first measurements, a first respiratory sinus arrhythmia value for each of the first plurality of time periods further comprises:

creating, from the first measurements taken of the user, a beat difference signal based on beat differences in a heart rate of the user;

creating, from the second measurements taken of the user, a respiration signal;

normalizing the beat difference signal and the respiration signal to have a common output range;

producing a correlation value indicative of a correlation between the normalized beat difference signal and the normalized respiration signal, the correlation value being the first respiratory sinus arrhythmia value.

8. A system for determining a first target respiration frequency for a user, the first target respiration frequency intended to improve a vagal tone of the user, the system including at least one sensor, at least one processor, and memory, the memory including instructions, which when executed by the at least one processor cause the at least one processor to perform operations comprising:

providing the user with a first indication to breathe at a pre-determined respiration frequency for each of a first plurality of time periods, each of the first plurality of time periods having a pre-determined respiration frequency that is unique among the pre-determined respiration frequencies for the first plurality;

using a first sensor, taking first measurements of the user for each of the first plurality of time periods;

determining, from the first measurements taken of the user, a first heart rate variability value for each of the first plurality of time periods;

using a second sensor, taking second measurements of the user for each of the first plurality of time periods;

determining, from the second measurements taken of the user and the first measurements, a first respiratory sinus arrhythmia value for each of the first plurality of time periods;

combining in whole or in part, for each of the first plurality of time periods, the first heart rate variability value and the first respiratory sinus arrhythmia value to create a first vagal tone value for each of the first plurality of time periods;

comparing the created plurality of first vagal tone values to each other to determine a first optimal vagal tone value; and

setting a first target respiration frequency based on a first respiration frequency from a time period corresponding to the first optimal vagal tone value, the first respiration frequency selected from the first pre-determined respiration frequency or a first actual respiration frequency.

9. The system of claim 8 further comprising instructions causing the at least one processor to perform operations comprising:

determining, from the second measurements taken of the user, the first actual respiration frequency for each of the first plurality of time periods;

determining, based on a comparison of the first actual respiration frequency to the first pre-determined respiration frequency for each of the first plurality of time periods, a respiration correlation value for each of the first plurality of time periods, wherein;

the first vagal tone value is created by combining, for each of the first plurality of time periods, the first heart rate variability value, the first respiratory sinus arrhythmia value, and the respiration correlation value to create the first vagal tone value for each of the first plurality of time periods.

10. The system of claim 9, wherein the first respiration frequency from the time period corresponding to the first optimal vagal tone value is the actual respiration frequency for the time period corresponding to the first optimal vagal tone value.

11. The method of claim 8, wherein a time period of the first plurality of time periods has a first duration, the system further comprising instructions causing the at least one processor to perform operations comprising:

providing to the user a second indication to breathe at a pre-determined respiration frequency for each of a second plurality of time periods, wherein;

each of the second plurality of time periods has a second duration less than the first duration,

each of the second plurality of time periods has a pre-determined respiration frequency that is unique among the pre-determined respiration frequencies for the second plurality, and

one of the second plurality of time periods has a pre-determined respiration frequency that is the first target respiration frequency;

determining, from third measurements taken of the user, a second heart rate variability value and, determining from the third measurements and from fourth measurements taken of the user a second respiratory sinus arrhythmia value for each of the second plurality time periods;

combining, in whole or in part, for each of the second plurality of time periods, the second heart rate variability and the second respiratory sinus arrhythmia value to create a second vagal tone value for each of the second plurality of time periods;

comparing the created plurality of second vagal tone values to each other to determine a second optimal vagal tone value; and

setting a second target respiration frequency based on a second respiration frequency from a time period corresponding to the second optimal vagal tone value, the second respiration frequency selected from the second pre-determined respiration frequency or a second actual respiration frequency.

12. The system of claim 11 further comprising instructions causing the at least one processor to perform operations comprising:

providing to the user a third indication to breathe at the second target respiration frequency for each of a third plurality of time periods;

providing to the user, for each breath in each of the third plurality of time periods, an indication to pause breathing for a pre-determined pause duration after each inhalation and after each exhalation, wherein the second target respiration frequency is maintained, and wherein the pre-determined pause duration is different for each of the third plurality of time periods;

determining, from fifth measurements taken of the user, a third heart rate variability value and, determining from the fifth measurements and from sixth measurements taken of the user a third respiratory sinus arrhythmia value for each of the third plurality time periods;

combining, in whole or in part, for each of the third plurality of time periods, the third heart rate variability and the third respiratory sinus arrhythmia value to create a third vagal tone value for each of the third plurality of time periods;

comparing the created plurality of third vagal tone values to each other to determine a third optimal vagal tone value; and

modifying the second target respiration frequency to include a target pause between inhalation and exhalation, the target pause based on the pre-determined pause duration corresponding to the third optimal vagal tone value.

13. The system of claim 8, wherein the determining, from the first measurements taken of the user, a first heart rate variability value comprises:

determining, from the first measurements, peak valley differences in a heart rate of the user; and

scaling the determined peak valley differences to vary within a range of zero to one.

14. The system of claim 8, wherein the determining, from the second measurements taken of the user and the first measurements, a first respiratory sinus arrhythmia value for each of the first plurality of time periods further comprises:

creating, from the first measurements taken of the user, a beat difference signal based on beat differences in a heart rate of the user;

creating, from the second measurements taken of the user, a respiration signal;

normalizing the beat difference signal and the respiration signal to have a common output range;

producing a correlation value indicative of a correlation between the normalized beat difference signal and the normalized respiration signal, the correlation value being the first respiratory sinus arrhythmia value.