Method and device for measuring venous blood oxygenation

• US 10,398,364 B2
• Filed: 02/13/2014
• Issued: 09/03/2019
• Est. Priority Date: 02/13/2013
• Status: Active Grant

• Current Assignee: Mespere LifeSciences Inc.
• Original Assignee: Mespere LifeSciences Inc.
• Inventors: Cheng, Xuefeng
• Primary Examiner(s): Winakur, Eric F
• Assistant Examiner(s): Liu, Chu Chuan
• Application Number:
  US14/767,698
• Publication Number:
  US 20150351675A1
• Time in Patent Office: 2,028 Days
• CPC Class Codes: A61B 2560/0261 using hydrostatic pressure
• CPC Class Codes: A61B 2562/0233 Special features of optical sensors or probes classified in A61B5/00
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/02116 of pulse wave amplitude A61B5/02225 takes precedence
• CPC Class Codes: A61B 5/02141 Details of apparatus construction, e.g. pump units or housings therefor, cuff pressurising systems, arrangements of fluid conduits or circuits A61B5/02233, A61B5/0235 take precedence
• CPC Class Codes: A61B 5/02427 Details of sensor
• CPC Class Codes: A61B 5/02433 for infrared radiation
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/6822 Neck

Abstract

A device for non-invasively measuring at least one parameter of a cardiac blood vessel in a patient comprises at least one light source that directs light at a tissue site on the patient; at least one photodetector adapted to receive light emitted by the light source and generate an output based on the received light, the output of said photodetector being correlated with a parameter of the blood vessel; and at least one probe for facilitating delivery of light from the light source to the tissue site, and receipt of light by the photodetector. The device may include a height sensor to adapt it for use to determine central venous pressure, or the configuration of light source(s) and photodetector(s) may be adapted to permit the device to provide attenuation correction in the determination of venous blood oxygenation.

Claims

1. A device comprising:

at least one light source adapted to emit light in the 400 nm to 1000 nm wavelength range;

at least one photodetector adapted to receive light emitted by the light source and translate said light into a recordable output wherein said light is reflected from or transmitted through tissue of the patient;

at least one probe which facilitates delivery of light from the light source to an external tissue site on the patient in the proximity of the jugular vein and receipt of light reflected from or transmitted through said patient site by the photodetector;

a pressure sensor mounted on the probe and connected to a reference patch that is compatible for placement on the skin via a tube configured to contain a liquid, wherein the pressure sensor provides a pressure reading useful to determine vertical height from the reference patch to the probe; and

a signal processing means adapted to receive the photodetector output and the pressure reading from the pressure sensor and to calculate a central venous pressure therefrom.

2. The device as defined in claim 1, wherein said light source and said photodetector are embedded in said probe.

3. The device as defined in claim 1, comprising a plurality of photodetectors.

4. The device as defined in claim 3, comprising a plurality of light sources, wherein each light source emits light that is received by a corresponding photodetector of said plurality of photodetectors.

5. The device as defined in claim 1, comprising a plurality of probes, wherein each probe comprises at least one light source and at least one photodetector.

6. The device as defined in claim 1, wherein the recordable output is current or voltage.