X-ray imaging with x-ray markers that provide adjunct information but preserve image quality

• US 10,398,398 B2
• Filed: 06/23/2014
• Issued: 09/03/2019
• Est. Priority Date: 11/26/2003
• Status: Active Grant

• Current Assignee: Hologic Incorporated
• Original Assignee: Hologic Incorporated
• Inventors: Ren, Baorui, Smith, Andrew P., Jing, Zhenxue, Stein, Jay, Defreitas, Kenneth F.
• Primary Examiner(s): Kao, Chih-Cheng
• Application Number:
  US14/312,434
• Publication Number:
  US 20140301529A1
• Time in Patent Office: 1,898 Days
• CPC Class Codes: A61B 5/1075 for measuring dimensions by non-invasive methods, e.g. for determining thickness of tissue layer A61B8/0858 takes precedence
• CPC Class Codes: A61B 6/0414 with compression means
• CPC Class Codes: A61B 6/502 for diagnosis of breast, i.e. mammography
• CPC Class Codes: A61B 6/544 dependent on patient size
• CPC Class Codes: A61B 6/583 using calibration phantoms

Abstract

A method and an apparatus for estimating a geometric thickness of a breast in mammography/tomosynthesis or in other x-ray procedures, by imaging markers that are in the path of x-rays passing through the imaged object. The markings can be selected to be visible or to be invisible when the composite markings/breast image is viewed in clinical settings. If desired, the contribution of the markers to the image can be removed through further processing. The resulting information can be used determining the geometric thickness of the body being x-rayed and thus setting imaging parameters that are thickness-related, and for other purposes. The method and apparatus also have application in other types of x-ray imaging.

Claims

1. A method comprising:

concurrently x-ray imaging a breast compression paddle comprising at least one paddle marker and a patient'"'"'s breast compressed between the compression paddle and an x-ray imaging receptor;

obtaining an x-ray image in which the at least one paddle marker and the breast are imaged, wherein an image of at least a part of the at least one paddle marker is superimposed on an image of the breast in the x-ray image, and wherein the at least one paddle marker is invisible within an outline of the breast in the x-ray image;

identifying at least one region of interest in the x-ray image that corresponds to at least a portion of the at least one paddle marker;

processing the at least one region of interest so as to derive geometric information regarding the at least one paddle marker image in the x-ray image; and

processing the geometric information to derive information regarding the compression paddle.

2. The method of claim 1, wherein the information regarding the compression paddle comprises at least one of a paddle height, a paddle deformation, a paddle orientation, and a compressed breast thickness.

3. The method of claim 2, further comprising storing the information regarding at least one of the paddle height, the paddle deformation, the paddle orientation, and the compressed breast thickness in association with stored image information regarding the imaged breast.

4. The method of claim 1, wherein the at least one paddle marker comprises a plurality of paddle markers.

5. The method of claim 4, wherein the plurality of paddle markers are disposed along a width of the compression paddle.

6. The method of claim 5, wherein the geometric information comprises a paddle height profile at each of the plurality of paddle markers.

7. The method of claim 4, wherein at least some of the plurality of paddle markers are visible in the x-ray image when viewed in clinical settings.

8. The method of claim 4, further comprising selecting the region of interest in the x-ray image that is likely to contain at least a substantial portion of the plurality of imaged paddle markers.

9. The method of claim 1, wherein the x-ray imaging receptor comprises at least one receptor marker, and wherein the at least one receptor marker is imaged concurrently with the breast compression paddle and the patient'"'"'s compressed breast.

10. A method comprising:

performing a first x-ray imaging acquisition concurrently on a breast compression paddle comprising at least one paddle marker and a patient'"'"'s breast compressed between the compression paddle and an x-ray imaging receptor, wherein the first x-ray imaging acquisition is performed with a first x-ray dose;

obtaining an x-ray image in which the at least one paddle marker and the breast are imaged, wherein an image of at least a part of the at least one paddle marker is superimposed on an image of the breast in the x-ray image, and wherein the at least one paddle marker is invisible within an outline of the breast in the x-ray image;

identifying at least one region of interest in the x-ray image that corresponds to at least a portion of the at least one paddle marker;

processing the at least one region of interest so as to derive geometric information regarding the compressed breast image in the x-ray image; and

processing the geometric information to derive compressed breast information.

11. The method of claim 10, further comprising performing a second x-ray imaging acquisition concurrently on the breast compression paddle comprising the at least one paddle marker and the patient'"'"'s breast compressed between the compression paddle and the x-ray imaging receptor, wherein the second x-ray imaging acquisition is performed with a second x-ray dose.

12. The method of claim 11, wherein the second x-ray dose is based at least in part on the compressed breast information.

13. The method of claim 11, wherein the second x-ray dose is higher than the first x-ray dose.

14. The method of claim 10, wherein the compressed breast information comprises breast density information.

15. The method of claim 14, further comprising processing the breast density information to derive predictor information related to cancer risk.

16. The method of claim 15, further comprising recording the cancer risk predictor information in association with image information regarding the imaged breast.

17. The method of claim 14, further comprising recording the breast density information in association with image information regarding the imaged breast.

18. The method of claim 14, further comprising displaying the breast density information in association with image information regarding the imaged breast.