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Compositions and methods for treating rosacea and acne

DC
  • US 10,398,641 B2
  • Filed: 09/08/2017
  • Issued: 09/03/2019
  • Est. Priority Date: 09/08/2016
  • Status: Active Grant
First Claim
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1. A method for treating acne vulgaris in a subject in need thereof, comprising topically administering to the subject a therapeutically effective amount of a breakable foam obtained from a foamable composition once daily for at least seven consecutive days, wherein the foamable composition comprises:

  • (a) a hydrophobic vehicle comprising;

    (i) about 70% to about 90% by weight of a hydrophobic solvent comprising;

    about 50% w/w of soybean oil;

    about 16.5% w/w to about 30.7% w/w of coconut oil;

    about 3.5% w/w to about 6.5% w/w of cyclomethicone; and

    about 1% w/w to about 6% w/w of light mineral oil; and

    (ii) about 10% to about 22% by weight of a foamer complex comprising;

    about 3.5% w/w of cetostearyl alcohol;

    about 2% w/w to about 4% w/w of stearic acid;

    about 1.8% w/w to about 3.3% w/w of myristyl alcohol;

    about 1% w/w to about 3% w/w of hydrogenated castor oil;

    about 1% w/w to about 3% w/w of beeswax;

    about 1% w/w to about 2% w/w of stearyl alcohol; and

    about 0.5% w/w to about 1.5% w/w of behenyl alcohol;

    (iii) minocycline in an amount ranging from about 1% w/w to about 4% w/w; and

    (b) a propellant in an amount ranging from about 3% to about 25% w/w; and

    wherein the foamable composition does not comprises silicon dioxide (SiO2),wherein seven days of topical treatment with the breakable foam at the therapeutically effective amount results in a maximum concentration of minocycline in plasma from the subject of about 2 ng/mL, as measured during a 24 hour period following the last topical administration, andwherein the subject is between 15 years old and 16 years and 11 months old.

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