Compositions and methods for treating rosacea and acne
DCFirst Claim
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1. A method for treating acne vulgaris in a subject in need thereof, comprising topically administering to the subject a therapeutically effective amount of a breakable foam obtained from a foamable composition once daily for at least seven consecutive days, wherein the foamable composition comprises:
- (a) a hydrophobic vehicle comprising;
(i) about 70% to about 90% by weight of a hydrophobic solvent comprising;
about 50% w/w of soybean oil;
about 16.5% w/w to about 30.7% w/w of coconut oil;
about 3.5% w/w to about 6.5% w/w of cyclomethicone; and
about 1% w/w to about 6% w/w of light mineral oil; and
(ii) about 10% to about 22% by weight of a foamer complex comprising;
about 3.5% w/w of cetostearyl alcohol;
about 2% w/w to about 4% w/w of stearic acid;
about 1.8% w/w to about 3.3% w/w of myristyl alcohol;
about 1% w/w to about 3% w/w of hydrogenated castor oil;
about 1% w/w to about 3% w/w of beeswax;
about 1% w/w to about 2% w/w of stearyl alcohol; and
about 0.5% w/w to about 1.5% w/w of behenyl alcohol;
(iii) minocycline in an amount ranging from about 1% w/w to about 4% w/w; and
(b) a propellant in an amount ranging from about 3% to about 25% w/w; and
wherein the foamable composition does not comprises silicon dioxide (SiO2),wherein seven days of topical treatment with the breakable foam at the therapeutically effective amount results in a maximum concentration of minocycline in plasma from the subject of about 2 ng/mL, as measured during a 24 hour period following the last topical administration, andwherein the subject is between 15 years old and 16 years and 11 months old.
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Abstract
Provided are compositions and methods for treating rosacea and acne. Specifically, a gel or foam composition having a tetracycline antibiotic and uses thereof for treating rosacea and acne are provided.
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Citations
4 Claims
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1. A method for treating acne vulgaris in a subject in need thereof, comprising topically administering to the subject a therapeutically effective amount of a breakable foam obtained from a foamable composition once daily for at least seven consecutive days, wherein the foamable composition comprises:
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(a) a hydrophobic vehicle comprising; (i) about 70% to about 90% by weight of a hydrophobic solvent comprising; about 50% w/w of soybean oil; about 16.5% w/w to about 30.7% w/w of coconut oil; about 3.5% w/w to about 6.5% w/w of cyclomethicone; and about 1% w/w to about 6% w/w of light mineral oil; and (ii) about 10% to about 22% by weight of a foamer complex comprising; about 3.5% w/w of cetostearyl alcohol; about 2% w/w to about 4% w/w of stearic acid; about 1.8% w/w to about 3.3% w/w of myristyl alcohol; about 1% w/w to about 3% w/w of hydrogenated castor oil; about 1% w/w to about 3% w/w of beeswax; about 1% w/w to about 2% w/w of stearyl alcohol; and about 0.5% w/w to about 1.5% w/w of behenyl alcohol; (iii) minocycline in an amount ranging from about 1% w/w to about 4% w/w; and (b) a propellant in an amount ranging from about 3% to about 25% w/w; and wherein the foamable composition does not comprises silicon dioxide (SiO2), wherein seven days of topical treatment with the breakable foam at the therapeutically effective amount results in a maximum concentration of minocycline in plasma from the subject of about 2 ng/mL, as measured during a 24 hour period following the last topical administration, and wherein the subject is between 15 years old and 16 years and 11 months old. - View Dependent Claims (2, 3, 4)
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Specification