Oral microbiota promotion for oral and/or sinus infections

• US 10,398,670 B2
• Filed: 09/15/2017
• Issued: 09/03/2019
• Est. Priority Date: 04/24/2017
• Status: Active Grant

• Current Assignee: Knoze Jr. Corporation
• Original Assignee: Knoze Jr. Corporation
• Inventors: Han, Shunsheng
• Primary Examiner(s): Rosenthal, Andrew S
• Application Number:
  US15/706,323
• Publication Number:
  US 20180303782A1
• Time in Patent Office: 718 Days
• CPC Class Codes: A23L 33/135 Bacteria or derivatives thereof, e.g. probiotics
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/7016 Disaccharides, e.g. lactose, lactulose lactobionic acid A61K31/7032
• CPC Class Codes: A61K 31/702 Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
• CPC Class Codes: A61K 31/719 Pullulans
• CPC Class Codes: A61K 31/733 Fructosans, e.g. inulin
• CPC Class Codes: A61K 35/644 Beeswax; Propolis; Royal jelly; Honey
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 36/54 Lauraceae (Laurel family), e.g. cinnamon or sassafras
• CPC Class Codes: A61K 36/736 Prunus, e.g. plum, cherry, peach, apricot or almond
• CPC Class Codes: A61K 36/898 Orchidaceae (Orchid family)
• CPC Class Codes: A61K 9/0053 Mouth and digestive tract, i.e. intraoral and peroral administration rectal administration A61K9/0031
• CPC Class Codes: A61K 9/0056 Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: B08B 3/10 with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration

Abstract

A method of promoting a desired oral microbiota to treat an oral and/or sinus infection condition in a subject in need of such treatment including providing a preformulated prebiotic edible composition including an amino acid containing ingredient comprising individual molecules of L-arginine; substantially removing a biofilm from surfaces within an oral cavity by heating the inside of the oral cavity to a temperature of about 100 deg F. to about 130 deg F.; wherein following removal of the biofilm, the composition is provided contained and at least partially dissolved within an oral cavity of the subject for a period of at least from about 30 seconds to about an hour on a daily basis of at least two consecutive days to promote an increased concentration of selected oral microbiota, the selected microbiota comprising Veillonella and Streptococcus, thereby treating the oral and/or sinus infection condition.

Claims

1. A method of promoting a desired oral microbiota to treat an oral and/or sinus infection condition in a subject in need of such treatment comprising:

providing a preformulated prebiotic edible composition comprising an amino acid containing ingredient comprising separate individual molecules of L-arginine;

substantially removing a biofilm from surfaces within an oral cavity comprising heating the inside of the oral cavity to a temperature of about 105 deg F. to about 130 deg F.;

wherein following removal of the biofilm, the composition is contained and at least partially dissolved within an oral cavity of the subject for a period of at least from about 30 seconds to about an hour on a daily basis of at least two consecutive days in an effective amount to selectively promote an increased concentration of selected oral microbiota, the selectively promoted microbiota comprising Veillonella and Streptococcus, thereby treating the oral and/or sinus infection condition.

2. The method of claim 1, wherein the oral and/or sinus infection condition comprises one or more of gingivitis, periodontitis, tonsillitis, rhinosinusitis, pharyngitis, and laryngitis.

3. The method of claim 1, wherein the composition is provided in a carrier.

4. The method of claim 3, wherein the carrier comprises a solid, powder or liquid.

5. The method of claim 3, wherein the carrier comprises one or more of a chewable tablet, an edible capsule, and a hygienic paste, and an edible food.

6. The method of claim 3, wherein the carrier is supported on a bioadhesive strip configured for adhesion within an oral cavity.

7. The method of claim 1, wherein the composition is provided within the oral cavity from a period of from about 2 consecutive days to about 60 consecutive days.

8. The method of claim 1, wherein heating the inside of the oral cavity comprises periodic oral rinsing with a heated liquid, each rinsing for about 10 seconds to about 1 minute over a period of from about 5 to about 15 minutes.

9. The method of claim 8, wherein removal of the biofilm comprises at least one of brushing and rubbing the oral cavity with the heated liquid.

10. The method of claim 1, wherein the at least one amino acid further comprises at least one of L-cysteine, DL-aspartic acid, L-glutamic acid, L-serine, and L-tyrosine.

11. The method of claim 1, wherein the amino acid containing ingredient is present in the composition at a weight percent level of from about 0.1 wt. % to about 99.9 wt. %.

12. The method of claim 1, wherein the amino acid containing ingredient is present in the composition at a weight percent level of from about 5.0 wt. % to about 95.0 wt.

13. The method of claim 1, wherein the composition further comprises a sugar containing ingredient, the sugar comprising one or more of monosaccharides, disaccharides, oligosaccharides, and polysaccharides.

14. The method of claim 13, wherein the sugar comprises one or more of mannose, lactose, malibiose, maltose, cellobiose, trehalose, raffinose, stachyose, and verbascose.

15. The method of claim 13, wherein the composition further comprises polysaccharide polymers.

16. The method of claim 15, wherein the polysaccharide polymers comprise one or more of pullulan and inulin.

17. The method of claim 13, wherein the sugar ingredient comprises jujube fruit extract comprising one or more of rhamnose, xylitol, arabitol, fructose, glucose, inositol, sucrose, and maltose.

18. The method of claim 13, wherein the sugar is present in the composition at a weight percent level of from about 0.1 wt. % to about 95 wt. %.

19. The method of claim 13, wherein the sugar is present in the composition at a weight percent level of from about 0.5 wt. % to about 95 wt. %.

20. The method of claim 13, wherein the sugar is present in the composition at a weight percent level of from about 5.0 wt. % to about 95.0 wt. %.

21. The method of claim 1, wherein at least one of the composition and oral cavity further comprises live bacteria comprising a lactic acid producing bacterium and a lactate fermenting bacterium at a level of from about 1000 to about 1,000,000,000 living cells.

22. The method of claim 1, wherein Streptococcus includes one or more of S. salivarius and S. thermophilus and wherein Veillonella comprises one or more of V. Dispar and V. Parvula.

23. A method of promoting a desired oral microbiota to treat an oral and/or sinus infection condition in a subject in need of such treatment comprising:

providing a preformulated prebiotic edible composition comprising an amino acid containing ingredient comprising separate individual molecules of L-arginine;

substantially removing a biofilm from surfaces within an oral cavity comprising heating the inside of the oral cavity to a temperature of about 100 deg F. to about 130 deg F. over a period of from about 5 to about 15 minutes;

wherein following removal of the biofilm, the composition is contained and at least partially dissolved within an oral cavity of the subject for a period of at least from about 30 seconds to about an hour on a daily basis of at least two consecutive days in an effective amount to selectively promote an increased concentration of selected oral microbiota, the selectively promoted microbiota comprising Veillonella and Streptococcus, thereby treating the oral and/or sinus infection condition.