×

Vaginal inserted estradiol pharmaceutical compositions and methods

DC
  • US 10,398,708 B2
  • Filed: 02/09/2018
  • Issued: 09/03/2019
  • Est. Priority Date: 10/22/2014
  • Status: Active Grant
First Claim
Patent Images

1. A method for treating moderate to severe dyspareunia in a human subject comprising:

  • intravaginally administering estradiol to the subject by manually inserting about two inches into the vagina a liquid pharmaceutical composition comprising about 4 μ

    g to about 25 μ

    g of estradiol, wherein the composition has a viscosity from about 50 cP to about 1000 cP at 25°

    C., wherein the composition comprises all of the estradiol and is encapsulated in a capsule, and wherein the composition is inserted while the subject is in a reclining position or in a standing position;

    wherein administration of the composition results in a decrease in the severity of moderate to severe dyspareunia in the subject within two to six weeks from the first administration.

View all claims
  • 9 Assignments
Timeline View
Assignment View
    ×
    ×