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Method and apparatus for obtaining a three-dimensional map of tympanic membrane thickness

  • US 10,401,141 B2
  • Filed: 11/14/2017
  • Issued: 09/03/2019
  • Est. Priority Date: 12/01/2016
  • Status: Active Grant
First Claim
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1. A method for acquiring a three-dimensional mapping of a physical specimen characterized by a surface and a refractive index, the method comprising:

  • a. obtaining a plurality of surface sub-images of a field of view of the surface of the physical specimen;

    b. obtaining a depth-resolved profile of the physical specimen at one or more fixed locations on each of the plurality of surface sub-images;

    c. extracting at least one of an image feature for use as a landmark for local registration of adjacent sub-images;

    d. pairwise locally registering sub-images to define a set of transformation matrices, each transformation matrix characterizing a coordinate transformation between neighboring sub-images;

    e. iteratively concatenating the transformation matrices so as to reference all of the transformation matrices to one of a plurality of coordinate frames of a plurality of sub-mosaics;

    f. repeating the process of steps (d)-(e) so as to reference all of the transformation matrices to a unitary global coordinate frame of the field of view of the surface of the physical specimen; and

    g. generating a three-dimensional globally co-registered mapping of the physical specimen based in part upon the depth-resolved profile at each of the plurality of locations.

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