Impedance based anatomy generation

• US 10,405,771 B2
• Filed: 12/04/2016
• Issued: 09/10/2019
• Est. Priority Date: 05/08/2009
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Rhythmia Medical, Inc. (Boston Scientific Corporation)
• Inventors: Harlev, Doron, Csendes, Alpar, Badics, Zsolt
• Primary Examiner(s): Hindenburg, Max F
• Application Number:
  US15/368,661
• Publication Number:
  US 20170086705A1
• Time in Patent Office: 1,010 Days
• CPC Class Codes: A61B 5/0044 for the heart
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/283 Invasive
• CPC Class Codes: A61B 5/287 Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
• CPC Class Codes: A61B 5/6858 with a distal basket, e.g. expandable basket
• CPC Class Codes: A61B 6/503 for diagnosis of the heart
• CPC Class Codes: A61B 8/0883 for diagnosis of the heart

Abstract

Methods and systems for the determination and representation of anatomy anatomical information are disclosed herein.

Claims

1. A method comprising:

inserting a catheter into a heart, the catheter comprising three or more electrodes;

causing the catheter to move to each of multiple, different positions in the heart;

for each of the multiple, different positions, causing current flow between at least some of the three or more electrodes and measuring electrical signals, from the current flow, at each of one or more of the three or more electrodes;

determining anatomical information about the heart by detecting surface boundaries of the heart based at least in part on impedance information generated based on the measured electrical signals; and

determining at least one of;

one or more distances between different surface boundaries of the heart, and one or more distances between at least one of the three or more electrodes and at least one of the surface boundaries of the heart.

2. The method of claim 1, comprising:

displaying the one or more distances between the different surface boundaries of the heart.

3. The method of claim 1, comprising:

displaying the one or more distances between the at least one of the three or more electrodes and the at least one of the surface boundaries of the heart.

4. The method of claim 1, wherein the impedance information comprises complex impedance information determined from the measured signals.

5. The method of claim 1, wherein the impedance information is based on at least one of a conductivity contrast and a permittivity contrast between homogenous and non-homogenous media.

6. The method of claim 1, wherein the impedance information is based on at least one of a conductivity contrast and a permittivity contrast between blood and surrounding tissue.

7. The method of claim 1, wherein the anatomical information accounts for a change in conductivity at a cardiac chamber boundary of the surface boundaries with a first conductivity inside the cardiac chamber boundary and a second conductivity outside the cardiac chamber boundary, the first conductivity being different from the second conductivity.

8. The method of claim 1, wherein the anatomical information accounts for a change in permittivity at a cardiac chamber boundary of the surface boundaries with a first permittivity inside the cardiac chamber boundary and a second permittivity outside the cardiac chamber boundary, the first permittivity being different from the second permittivity.

9. The method of claim 1, wherein detecting the surface boundaries of the heart comprises determining a closed and parameterized surface around at least a portion of the catheter based on the measured electrical signals, the surface boundaries representing boundaries at which at least one of a conductivity and a permittivity changes.

10. The method of claim 1, wherein detecting the surface boundaries of the heart comprises detecting the surface boundaries of the heart based at least in part on a magnitude of a distortion field based at least in part on a difference between a field calculated based on the measured electrical signals and a field in a homogenous medium.

11. A method comprising:

inserting a catheter into a heart, the catheter comprising multiple, spatially distributed electrodes including multiple sets of electrodes, each set comprising at least two electrodes;

for each of the multiple different sets of electrodes, causing current to flow between at least some of the electrodes and in response to current flow, measuring an electrical signal at each of one or more measuring electrodes;

determining anatomical information about the heart by detecting surfaces of the heart based at least in part on complex impedance information generated based on the measured signals; and

determining at least one of a distance between different surfaces of the heart, and a distance between one of the electrodes and one of the surfaces of the heart.

12. The method of claim 11, comprising at least one of;

displaying the distance between the different surfaces of the heart; and

displaying the distance between the one of the electrodes and the one of the surfaces of the heart.

13. The method of claim 11, wherein the complex impedance information is based on at least one of a conductivity contrast and a permittivity contrast between homogenous and non-homogenous media.

14. The method of claim 11, wherein the complex impedance information is based on at least one of a conductivity contrast and a permittivity contrast between blood and surrounding tissue.

15. The method of claim 11, wherein determining the anatomical information comprises:

distinguishing signals indicative of cardiac electrical activity from the measured signals based on the current flow; and

determining the anatomical information based on the measured signals based on the current flow.

16. A system comprising:

a catheter comprising three or more electrodes configured to inject a current and to measure electrical signals in response to the injected current; and

a processing unit configured to determine anatomical information about the heart by detecting surfaces of the heart based at least in part on impedance information generated based on the measured signals, wherein the processing unit determines at least one of;

one or more distances between different surfaces of the heart, and one or more distances between at least one of the three or more electrodes and at least one of the surfaces of the heart.

17. The system of claim 16, wherein the anatomical information accounts for a change in conductivity at a cardiac chamber boundary with a first conductivity inside the cardiac chamber boundary and a second conductivity outside the cardiac chamber boundary, the first conductivity being different from the second conductivity.

18. The system of claim 16, wherein the anatomical information accounts for a change in permittivity at a cardiac chamber boundary with a first permittivity inside the cardiac chamber boundary and a second permittivity outside the cardiac chamber boundary, the first permittivity being different from the second permittivity.

19. The system of claim 16, wherein the impedance information comprises complex impedance information determined from the measured signals and the complex impedance information is based on at least one of a conductivity contrast and a permittivity contrast between at least one of:

homogenous and non-homogenous media, and blood and surrounding tissue.

20. The system of claim 16, wherein the electrodes on the catheter are configured to measure cardiac signals in response to electrical activity in the heart and the processing unit is configured to determine physiological information at multiple locations on the surfaces of the heart based on the determined positions of the electrodes and the measured cardiac signals.