Coated surgical mesh, and corresponding systems and methods
First Claim
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1. A surgical mesh coated with a crosslinked basement membrane preparation comprising Type IV collagen and laminin, wherein the crosslinked basement membrane preparation contains no more than 0.024 mg/ml total concentration of glucose, amino acids and salts having a molecular weight of 2000 daltons or less.
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Abstract
Disclosed herein are medical products, including a surgical mesh, with a layer of dehydrated modified basement membrane preparation formed thereon. The basement membrane has been modified before dehydration of remove low molecular weight components. In some embodiments, the basement membrane is crosslinked. Methods of making and using the products also are disclosed.
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Citations
18 Claims
- 1. A surgical mesh coated with a crosslinked basement membrane preparation comprising Type IV collagen and laminin, wherein the crosslinked basement membrane preparation contains no more than 0.024 mg/ml total concentration of glucose, amino acids and salts having a molecular weight of 2000 daltons or less.
- 11. A surgical mesh coated with a basement membrane preparation comprising Type IV collagen and laminin, said basement membrane preparation is crosslinked with a dialdehyde, wherein said crosslinked basement membrane preparation contains no more than 0.024 mg/ml total concentration of glucose, amino acids and salts having a molecular weight of 2000 daltons or less.
Specification