Methods of providing optimized drug-eluting stent assemblies
First Claim
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1. A method of providing a stent assembly which comprises:
- providing a stent configured to be positioned in the body lumen; and
disposing a knitted stent jacket comprising an expansible mesh structure coaxially over a radial portion of the stent and along an entire length thereof, the mesh structure being formed from a single fiber and having a coverage area over the stent of about 10% to less than 20% relative to the total coverage area over the stent including a plurality of apertures therein, the apertures having approximate aperture diameters greater than 20 micrometers up to a minimum center dimension of 234 micrometers,wherein the stent assembly is configured to elute an amount of an active pharmaceutical agent that is present therein, andwherein the fiber has a diameter of approximately 7 micrometers to 40 micrometers.
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Abstract
Methods of providing a stent assembly that includes a stent jacket formed from an expansible mesh structure having apertures and that includes a fiber having a diameter of about 7 micrometers and about 40 micrometers, and an expansible stent operatively associated with the stent jacket. The method further comprises administering to the subject an active pharmaceutical ingredient (API) eluted from the stent assembly.
174 Citations
29 Claims
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1. A method of providing a stent assembly which comprises:
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providing a stent configured to be positioned in the body lumen; and disposing a knitted stent jacket comprising an expansible mesh structure coaxially over a radial portion of the stent and along an entire length thereof, the mesh structure being formed from a single fiber and having a coverage area over the stent of about 10% to less than 20% relative to the total coverage area over the stent including a plurality of apertures therein, the apertures having approximate aperture diameters greater than 20 micrometers up to a minimum center dimension of 234 micrometers, wherein the stent assembly is configured to elute an amount of an active pharmaceutical agent that is present therein, and wherein the fiber has a diameter of approximately 7 micrometers to 40 micrometers. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A method of providing a stent assembly which comprises:
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providing a stent configured to be positioned in the body lumen; coaxially disposing a knitted stent jacket comprising an expansible mesh structure over a circumference of the stent and along a length thereof, the mesh structure being formed from a single fiber and having a coverage area of about 9% to less than 16% relative to the coverage area of a plurality of apertures therein, the apertures having approximate aperture diameters greater than 20 micrometers up to a minimum center dimension of 234 micrometers; and providing at least one coating on an inner side or an outer side of the knitted stent jacket; wherein the stent assembly elutes an amount of an active pharmaceutical agent that is present therein, and wherein the fiber has a diameter of approximately 7 micrometers to 40 micrometers.
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Specification