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PSMA binding ligand-linker conjugates and methods for using

  • US 10,406,240 B2
  • Filed: 05/26/2017
  • Issued: 09/10/2019
  • Est. Priority Date: 08/17/2007
  • Status: Active Grant
First Claim
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1. A compound of the formula
B-L-Cor a salt thereof, whereinB is a ligand of prostate specific membrane antigen (PSMA) that is a urea of two amino acids, wherein the two amino acids are independently selected from asparagine, aspartic acid, cysteine, glutamic acid, lysine, glutamine, arginine, serine, ornithine, threonine and combinations thereof;

  • L is a divalent linker of 7 to 20 atoms in length, the divalent linker comprising a divalent alkylene group, a cycloalkylenecarbonyl group and a hydrophobic side chain divalent group comprising an arylalkyl side chain; and

    C is a chelating group of the formula

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