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Adjustable rate drug delivery implantable device

  • US 10,406,336 B2
  • Filed: 07/27/2017
  • Issued: 09/10/2019
  • Est. Priority Date: 08/03/2016
  • Status: Active Grant
First Claim
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1. An implantable device comprising:

  • a casing, a semi-permeable membrane plug at or near a first end of the casing, a piston, beads, and an opening for release of the beads from the implantable device within a body of a human or an animal;

    a sensor configured to monitor a concentration of a drug in the body of the human or the animal;

    a side wall at or near a second end of the casing, wherein the casing is substantially tubular having at least the first end of the casing and the second end of the casing, and the second end of the casing is opposite the first end of the casing;

    a sonicator, wherein the sonicator is located between the piston and the side wall;

    a first chamber between the semi-permeable membrane plug and the piston, a second chamber between the piston and the sonicator, and a third chamber between the second chamber and the side wall, wherein the first chamber comprises a salt solution, the second chamber comprises the beads, and the third chamber comprises a foam;

    wherein the implantable device is configured to be implanted within the body of the human or the animal during delivery of the beads into the body of the human or the animal;

    wherein the beads comprise a core and a shell with the core being enclosed by the shell and the beads contain the drug; and

    wherein the implantable device is configured to produce a desired flow rate of elution of the drug from the implantable device when the implantable device is implanted within the body of the human or the animal, wherein the sonicator is configured to sonicate and increase porosity of the foam.

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