Adjustable rate drug delivery implantable device
First Claim
1. An implantable device comprising:
- a casing, a semi-permeable membrane plug at or near a first end of the casing, a piston, beads, and an opening for release of the beads from the implantable device within a body of a human or an animal;
a sensor configured to monitor a concentration of a drug in the body of the human or the animal;
a side wall at or near a second end of the casing, wherein the casing is substantially tubular having at least the first end of the casing and the second end of the casing, and the second end of the casing is opposite the first end of the casing;
a sonicator, wherein the sonicator is located between the piston and the side wall;
a first chamber between the semi-permeable membrane plug and the piston, a second chamber between the piston and the sonicator, and a third chamber between the second chamber and the side wall, wherein the first chamber comprises a salt solution, the second chamber comprises the beads, and the third chamber comprises a foam;
wherein the implantable device is configured to be implanted within the body of the human or the animal during delivery of the beads into the body of the human or the animal;
wherein the beads comprise a core and a shell with the core being enclosed by the shell and the beads contain the drug; and
wherein the implantable device is configured to produce a desired flow rate of elution of the drug from the implantable device when the implantable device is implanted within the body of the human or the animal, wherein the sonicator is configured to sonicate and increase porosity of the foam.
0 Assignments
0 Petitions
Accused Products
Abstract
Embodiments herein relate to an implantable device comprising a casing, a semi-permeable membrane plug at or near a first end of the casing, a piston, beads, and an opening for release of the beads from the implantable device within a body of a human or an animal; wherein the implantable device is configured to be implanted within the body of the human or the animal during delivery of the beads into the body of the human or the animal; wherein the beads comprise a core and a shell with the core being enclosed by the shell and the beads contain a drug; and wherein the implantable device is configured to produce a desired flow rate of elution of the drug from the implantable device when the implantable device is implanted within the body of the human or the animal.
82 Citations
22 Claims
-
1. An implantable device comprising:
-
a casing, a semi-permeable membrane plug at or near a first end of the casing, a piston, beads, and an opening for release of the beads from the implantable device within a body of a human or an animal; a sensor configured to monitor a concentration of a drug in the body of the human or the animal; a side wall at or near a second end of the casing, wherein the casing is substantially tubular having at least the first end of the casing and the second end of the casing, and the second end of the casing is opposite the first end of the casing; a sonicator, wherein the sonicator is located between the piston and the side wall; a first chamber between the semi-permeable membrane plug and the piston, a second chamber between the piston and the sonicator, and a third chamber between the second chamber and the side wall, wherein the first chamber comprises a salt solution, the second chamber comprises the beads, and the third chamber comprises a foam; wherein the implantable device is configured to be implanted within the body of the human or the animal during delivery of the beads into the body of the human or the animal; wherein the beads comprise a core and a shell with the core being enclosed by the shell and the beads contain the drug; and wherein the implantable device is configured to produce a desired flow rate of elution of the drug from the implantable device when the implantable device is implanted within the body of the human or the animal, wherein the sonicator is configured to sonicate and increase porosity of the foam. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
-
-
14. An implantable device comprising:
-
a casing, a semi-permeable membrane plug at or near a first end of the casing, a piston, beads, and an opening for release of the beads from the implantable device within a body of a human or an animal; a sensor configured to monitor a concentration of in the body of the human or the animal; a side wall at or near a second end of the casing, wherein the casing is substantially tubular having at least the first end of the casing and the second end of the casing, and the second end of the casing is opposite the first end of the casing; a plate comprising open holes that allow fluid flow across the plate through the open holes and closed holes that prevent fluid flow across the plate through the closed holes, wherein the plate is located between the piston and the side wall; a first chamber between the semi-permeable membrane plug and the piston, a second chamber between the piston and the plate, and a third chamber between the second chamber and the side wall, wherein the first chamber comprises a salt solution, the second chamber comprises the beads, and the third chamber comprises a foam; wherein the implantable device is configured to be implanted within the body of the human or the animal during delivery of the beads into the body of the human or the animal; wherein the beads comprise a core and a shell with the core being enclosed by the shell and the beads contain drug; and wherein the implantable device is configured to produce a desired flow rate of elution of the drug from the implantable device when the implantable device is implanted within the body of the human or the animal, and wherein the plate is configured to increase the desired flow rate of elution of the drug from the implantable device by transforming one or more of the closed holes into one or more additional open holes. - View Dependent Claims (15, 16, 17, 18, 19, 21, 22)
-
-
20. The implantable device of 17, wherein the metal-containing material comprises metallic particles and wherein the first and/or second materials comprise polymers.
Specification