Methods and systems for intraventricular brain stimulation

• US 10,406,351 B2
• Filed: 02/07/2018
• Issued: 09/10/2019
• Est. Priority Date: 05/01/2013
• Status: Active Grant

• Current Assignee: Sherwin Hua
• Original Assignee: Sherwin Hua
• Inventors: Hua, Sherwin
• Primary Examiner(s): Gedeon, Brian T
• Application Number:
  US15/891,231
• Publication Number:
  US 20180229027A1
• Time in Patent Office: 580 Days
• Field of Search: None
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/36064 Epilepsy
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Abstract

The present application is directed to devices and methods that can treat dementia or other brain disorders via electrical stimulation. Embodiments disclosed herein utilize brain stimulation of brain areas involved in memory and cognition through an intraventricular approach. Brain stimulation is combined with CSF flow in an intraventricular electrode having one or more passageways to permit fluid to flow therethrough. For example, an intraventricular electrode shunt catheter can be safely placed in any part of the ventricular system and through any foramen or aqueduct of the ventricular system without fear of obstruction to CSF flow.

Claims

1. A neuromodulation system configured to pass into, within, or through brain tissue from a lateral entry site to provide bilateral deep brain stimulation, the system comprising:

an electrode catheter comprising one or more passageways for fluid, wherein the electrode catheter comprises at least one fluid drainage perforation that is configured to drain fluid through the one or more passageways, wherein the electrode catheter is configured to provide both electrical and drainage capabilities; and

a plurality of electrodes or effectors carried by the electrode catheter configured for bilateral stimulation and configured to modulate neural activity thereby modulating a neural state, wherein the at least one fluid drainage perforation is located between the plurality of electrodes or effectors;

wherein the electrode catheter is sized and configured to pass through one lateral ventricle in a unilateral approach through a foramen of Monroe on an ipsilateral side into the third ventricle, and a tip of the electrode catheter is configured to curve under the ipsilateral fornix to the contralateral fornix by curving from the foramen of Monroe on the ipsilateral side past the ipsilateral fornix to the contralateral fornix.

2. The neuromodulation system of claim 1, wherein the neural activity modulated comes from one of more of the following:

brain cells, neural fibers, fornix, thalamus, anterior nucleus of thalamus, a structure within the circuit of Papez, and hypothalamus.

3. The neuromodulation system of claim 1, wherein the neural state is one or more of the following neural states:

a normal neural state, an abnormal neural state, an abnormal neural state related to seizure, an abnormal neural state related to epilepsy, an abnormal neural state related to Alzheimer'"'"'s disease, an abnormal neural state related to Mild Cognitive Impairment, an abnormal neural state related to normal pressure hydrocephalus, an abnormal neural state related to Attention Deficit and Hyperactivity Disorder, an abnormal neural state related to encephalopathy, an abnormal neural state related to stroke, an abnormal neural state related to Parkinson'"'"'s Disease, an abnormal neural state related to neurodegenerative disease, an abnormal neural state related to cerebral palsy, an abnormal neural state related to schizophrenia, an abnormal neural state related to neuropsychiatric disorder.

4. The neuromodulation system of claim 1, wherein the modulation of neural activity comprises one or more of the following:

an increase in neural activity, a decrease in neural activity, a modulation of memory, attention, concentration.

5. The neuromodulation system of claim 1, wherein the electrode catheter comprises perforations to permit cerebral spinal fluid to flow therethrough.

6. The neuromodulation system of claim 1, wherein the passageway is configured to permit cerebrospinal fluid to flow out of the cranium to drain into a body cavity including the circulatory system, peritoneum, or pleural space, and wherein the passageway comprises a shunt system with a valve controlling cerebrospinal fluid flow.

7. The neuromodulation system of claim 1, wherein the passageway is configured so as to not be open to cerebrospinal fluid flow outside the cranium.

8. The neuromodulation system of claim 1, wherein the system is configured to allow the electrode or effector to reach both the fornix and anterior nucleus of thalamus.

9. The neuromodulation system of claim 1, wherein the electrode catheter is configured to use mechanical properties to maintain contact with neural structures on the wall of the ventricle or a foramen of Monroe.

10. The neuromodulation system of claim 1, wherein the catheter diameter can be enlarged or decreased to better fit within the ventricle or a foramen of Monroe so that the electrode or effector is in better contact with the neural structures on the wall of the ventricular system.

11. The neuromodulation system of claim 1, wherein the electrode catheter is configured to be inserted to the target using one or more of the following means:

stereotactic guidance, an endoscopic viewer, fluoroscopic visualization guided by radio-opaque substance, and ventriculography.

12. The neuromodulation system of claim 1, wherein the electrode catheter is configured to be introduced supratentorially.

13. The neuromodulation system of claim 1, further comprising a straight stylet that is configured to be inserted into the electrode catheter, wherein removal of the straight stylet from the electrode catheter causes the electrode catheter to curve.

14. The neuromodulation system of claim 1, wherein the electrode catheter is configured to be introduced laterally through a burr hole.

15. The neuromodulation system of claim 1, wherein the electrode is shaped to conform to the shape of the lateral ventricle on the ipsilateral side through the foramen of Monroe on the ipsilateral side through the third ventricle through the foramen of Monroe on the contralateral side into the contralateral lateral ventricle.

16. The neuromodulation system of claim 1, wherein the tip of the electrode catheter is configured to curve in a “

V”

shape.

17. The neuromodulation system of claim 1, comprising electrodes on both sides of a bend in the “

V”

shape configured to provide bilateral stimulation.

18. The neuromodulation system of claim 1, wherein the at least one fluid drainage perforation is configured to drain fluid out of the cranium.

19. The neuromodulation system of claim 1, wherein the at least one fluid drainage perforation is configured to drain fluid from at least one of the left ventricle, right ventricle, and third ventricle.

20. The neuromodulation system of claim 1, wherein the plurality of electrodes or effectors are directional.