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Use of microvesicles in analyzing nucleic acid profiles

  • US 10,407,728 B2
  • Filed: 07/06/2015
  • Issued: 09/10/2019
  • Est. Priority Date: 09/09/2009
  • Status: Active Grant
First Claim
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1. A method of treating glioblastoma in a subject, comprising:

  • a. extracting RNA transcripts from at least one microvesicle isolated from a biological sample from the subject;

    b. measuring the expression level of the genes consisting of TMSL3, GNG11, A_24_P530977, B2M, RGS10, GPX1, RPS29, ENST00000357697, LOC390427, SLITRK4, LGAL27, ENST00000325151, RALGDS, MESP1, SYMPK, C17orf74, J03651, FZD9, AL566332, ZNF784, SERPINB1, FOXD3, ENST00000325371, THC2504037, RNF151, ENST00000360514, BAX, POLD1, RKHD1, LGR4, CV575560 in the extracted RNA transcripts;

    c. creating a genetic profile of the subject based on the measured expression level of each gene;

    d. comparing the genetic profile to a reference profile using clustering analysis or principle component analysis; and

    e. treating glioblastoma in the subject having a statistically significant difference in the genetic profile compared to the reference profile.

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