Collateral flow channel sealant delivery methods and systems

• US 10,413,300 B2
• Filed: 06/14/2016
• Issued: 09/17/2019
• Est. Priority Date: 06/22/2015
• Status: Active Grant

• Current Assignee: Pulmonx Corp.
• Original Assignee: Pulmonx Corp.
• Inventors: Radhakrishnan, Sri, Olivera, Ryan
• Primary Examiner(s): Natnithithadha, Navin
• Assistant Examiner(s): Messersmith, Eric J
• Application Number:
  US15/182,453
• Publication Number:
  US 20160367259A1
• Time in Patent Office: 1,190 Days
• CPC Class Codes: A61B 17/1204 temporary occlusion
• CPC Class Codes: A61B 17/12104 in an air passage
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 2562/0247 Pressure sensors
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/4848 Monitoring or testing the effects of treatment, e.g. of medication
• CPC Class Codes: A61F 2002/043 Bronchi
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61M 16/0406 implanted flow modifiers
• CPC Class Codes: A61M 16/042 with separate conduits for in-and expiration gas, e.g. for limited dead volume
• CPC Class Codes: A61M 16/0459 one cuff behind another
• CPC Class Codes: A61M 2025/0001 for pressure measurement
• CPC Class Codes: A61M 2202/0413 Blood
• CPC Class Codes: A61M 2202/0468 non-physiological
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 25/0147 with movable mechanical means, e.g. pull wires
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00

Abstract

Devices, methods, and systems are provided for occluding a collateral flow channel between a target lung compartment and an adjacent lung compartment. A video-assisted thoracoscopic device is inserted into a thoracic cavity of a patient and positioned at a fissure between a target lung compartment and an adjacent lung compartment. A collateral flow channel between the target lung compartment and the adjacent lung compartment is then identified using the video-assisted thoracoscopic device and an agent is injected into the collateral flow channel, thereby reducing the collateral flow channel.

Claims

1. A method for occluding a collateral flow channel between a target lung compartment and an adjacent lung compartment, said method comprising:

inserting a video-assisted thoracoscopic device into a thoracic cavity of a patient;

positioning the video-assisted thoracoscopic device at a fissure between a target lung compartment and an adjacent lung compartment;

identifying a collateral flow channel between the target lung compartment and the adjacent lung compartment using the video-assisted thoracoscopic device;

inserting a needle into the thoracic cavity and through tissue forming the collateral flow channel; and

injecting an agent through the needle and into the collateral flow channel, thereby reducing the collateral flow channel.

2. The method of claim 1, further comprising placing a clip on the collateral channel thereby pinching closed the collateral channel.

3. The method of claim 2, wherein the clip is a normally closed clip.

4. The method of claim 1, further comprising cutting tissue at the collateral flow channel thereby disrupting the collateral flow channel.

5. The method of claim 1, wherein the collateral flow channel is sealed.

6. The method of claim 1, wherein the agent is a sealant.

7. The method of claim 1, wherein the agent is a sclerosing agent.

8. The method of claim 1, wherein the agent is autologous blood.

9. A method as in claim 1, further comprising:

accessing the target lung compartment using an endobronchial isolation catheter;

isolating the target lung compartment using the endobronchial isolation catheter;

measuring pressure or flow within the target lung compartment; and

verifying the collateral flow channel has been sealed based on the measured pressure or flow.

10. A method as in claim 1, further comprising placing an endobronchial valve within an airway leading to the target lung compartment.

11. A method as in claim 10, wherein the endobronchial valve is a one-way flow control valve configured to allow air to flow out of the target lung compartment and prevent air flow into the target lung compartment.

12. A method for occluding a collateral flow channel between a target lung compartment and an adjacent lung compartment, said method comprising:

inserting a video-assisted thoracoscopic device into a thoracic cavity of a patient;

positioning the video-assisted thoracoscopic device at a fissure between a target lung compartment and an adjacent lung compartment;

identifying a collateral flow channel between the target lung compartment and the adjacent lung compartment using the video-assisted thoracoscopic device;

placing a clip into the thoracic cavity and on the collateral channel thereby pinching closed the collateral channel.

13. A method for occluding a collateral flow channel between a target lung compartment and an adjacent lung compartment, said method comprising:

inserting a video-assisted thoracoscopic device into a thoracic cavity of a patient;

positioning the video-assisted thoracoscopic device at a fissure between a target lung compartment and an adjacent lung compartment;

identifying a collateral flow channel between the target lung compartment and the adjacent lung compartment using the video-assisted thoracoscopic device;

cutting tissue at the collateral flow channel from the thoracic cavity thereby disrupting the collateral flow channel.