System for inducing desirable temperature effects on body tissue
First Claim
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1. A system for inducing desirable temperature effects on a target body tissue disposed about a blood vessel, the system comprising:
- a catheter body having a proximal end and a distal end with an axis therebetween;
a radially expandable member comprising a balloon supported by the distal end of the catheter body,the expandable member having a low profile insertion configuration and a larger profile configuration; and
a plurality of electrodes included on a plurality of separate flexible circuits each adhesively bonded to an outer surface of the balloon so as to radially couple with a wall of the blood vessel and define a plurality of remodeling zones in a tissue treatment area when the expandable member is in the large profile configuration within the blood vessel, wherein the plurality of electrodes are distributed circumferentially about the balloon such that the plurality of remodeling zones extend about the circumference of the blood vessel, and wherein the flexible circuits are sufficiently flexible to allow folding and inflation of the balloon,wherein the plurality of electrodes includes a plurality of pairs of electrodes,wherein each pair of electrodes out of the plurality of pairs of electrodes are disposed on one of the plurality of separate flexible circuits, each one of the plurality of separate flexible circuits including a polymeric substrate;
wherein the plurality of electrodes are configured to transmit a tissue remodeling energy to each of the plurality of remodeling zones such that when at least some remodeling zones of the plurality include collateral tissue without the target body tissue, the tissue remodeling energy is transmitted to the at least some remodeling zones heating the collateral tissue without causing thermal damage, while the tissue remodeling energy transmitted to remodeling zones including both the target tissue and collateral tissue heats the target tissue sufficiently to efficaciously alter the target tissue without causing thermal damage to the collateral healthy tissue.
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Accused Products
Abstract
A catheter and catheter system may be used to treat disease tissue by gentle heating in combination with gentle or standard dilation. An elongate flexible catheter body with a radially expandable balloon having a plurality of electrodes engage tissue including diseased tissue when the structure expands.
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Citations
28 Claims
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1. A system for inducing desirable temperature effects on a target body tissue disposed about a blood vessel, the system comprising:
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a catheter body having a proximal end and a distal end with an axis therebetween; a radially expandable member comprising a balloon supported by the distal end of the catheter body, the expandable member having a low profile insertion configuration and a larger profile configuration; and a plurality of electrodes included on a plurality of separate flexible circuits each adhesively bonded to an outer surface of the balloon so as to radially couple with a wall of the blood vessel and define a plurality of remodeling zones in a tissue treatment area when the expandable member is in the large profile configuration within the blood vessel, wherein the plurality of electrodes are distributed circumferentially about the balloon such that the plurality of remodeling zones extend about the circumference of the blood vessel, and wherein the flexible circuits are sufficiently flexible to allow folding and inflation of the balloon, wherein the plurality of electrodes includes a plurality of pairs of electrodes, wherein each pair of electrodes out of the plurality of pairs of electrodes are disposed on one of the plurality of separate flexible circuits, each one of the plurality of separate flexible circuits including a polymeric substrate; wherein the plurality of electrodes are configured to transmit a tissue remodeling energy to each of the plurality of remodeling zones such that when at least some remodeling zones of the plurality include collateral tissue without the target body tissue, the tissue remodeling energy is transmitted to the at least some remodeling zones heating the collateral tissue without causing thermal damage, while the tissue remodeling energy transmitted to remodeling zones including both the target tissue and collateral tissue heats the target tissue sufficiently to efficaciously alter the target tissue without causing thermal damage to the collateral healthy tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A system for inducing desirable temperature effects on a target body tissue disposed about a blood vessel, the system comprising:
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an intravascular catheter body having a proximal end and a distal end with an axis therebetween; an intravascular balloon supported by the distal end of the catheter body, the balloon having a low profile insertion configuration and a larger profile configuration; and a plurality of flex circuits distributed about the balloon, each flex circuit including a polymeric substrate and a pair of electrodes mounted thereto, the flexible circuits being sufficiently flexible to allow folding and inflation of the balloon, the electrodes having a predetermined bipolar pair separation distance therebetween, the polymeric substrate being adhesively bonded to an outer surface of the balloon, wherein the plurality of flex circuits define a plurality of remodeling zones in a tissue treatment area that extend about a circumference of the blood vessel when the balloon is in the larger profile configuration within the blood vessel; a power source configured to electrically couple with the electrodes of the flex circuits, and to transmit a tissue remodeling energy between the electrodes of the pairs on the flex circuits so as to provide an associated remodeling zone of the plurality of remodeling zones in the tissue treatment area for each pair of electrodes of the plurality when the balloon is inflated to the large profile configuration within the blood vessel, wherein the power source is further configured to transmit the tissue remodeling energy to each of the plurality of remodeling zones such that when at least some remodeling zones of the plurality include collateral healthy tissue without the target body tissue, the tissue remodeling energy is transmitted to the at least some remodeling zones heating the collateral healthy tissue without causing thermal damage, while the tissue remodeling energy transmitted to remodeling zones including both the target tissue and collateral tissue heats the target tissue sufficiently to efficaciously alter the target tissue without causing thermal damage to the collateral healthy tissue.
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22. A method for inducing desirable temperature effects on a target body tissue disposed about a body lumen of a patient, the method comprising:
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positioning a radially expandable member supported by a distal end of a catheter body within the lumen adjacent the target body tissue to be heated, the expandable member having a low profile insertion configuration and a larger profile configuration; wherein the expandable member comprises a balloon having a plurality of flexible circuits adhesively bonded to an outer surface thereof, each flexible circuit including a polymeric substrate bearing a pair of electrodes, each pair of electrodes collectively defining a plurality of electrodes, the flexible circuits being sufficiently flexible to allow folding and inflation of the balloon; expanding the expandable member to the larger profile configuration within the lumen so as to engage the plurality of electrodes mounted on the plurality of flexible circuits against a wall of the lumen, the plurality of electrodes defining a plurality of remodeling zones in a tissue treatment area that extend about a circumference of the body lumen; energizing the plurality of electrodes to transmit a remodeling energy to each of the plurality of remodeling zones, with a controller having a power source electrically coupled to the plurality of electrodes; and heating collateral healthy tissue in at least some remodeling zones in the tissue treatment area with the remodeling energy without causing thermal damage, and heating both the target body tissue and collateral healthy tissue in remodeling zones including the target tissue so as to efficaciously alter the target tissue while inhibiting damage to collateral healthy tissue of the wall of the lumen. - View Dependent Claims (23, 24, 25, 26, 27, 28)
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Specification