Multiwavelength surgical laser

• US 10,413,362 B2
• Filed: 11/18/2015
• Issued: 09/17/2019
• Est. Priority Date: 12/29/2014
• Status: Active Grant

• Current Assignee: Cyclone Biosciences LLC
• Original Assignee: InnovaQuartz Inc. (Endo International PLC)
• Inventors: Griffin, Stephen E.
• Primary Examiner(s): Farah, Ahmed M
• Application Number:
  US14/945,053
• Publication Number:
  US 20160184019A1
• Time in Patent Office: 1,399 Days
• Field of Search: 606 3- 18, 607 88, 607 89, 128898
• CPC Class Codes: A61B 18/20 using laser
• CPC Class Codes: A61B 18/22 the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
• CPC Class Codes: A61B 2018/00547 Prostate
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00589 Coagulation
• CPC Class Codes: A61B 2018/00601 Cutting
• CPC Class Codes: A61B 2018/00625 Vaporization
• CPC Class Codes: A61B 2018/1807 using light other than laser radiation
• CPC Class Codes: A61B 2018/2015 Miscellaneous features
• CPC Class Codes: A61B 2018/2035 Beam shaping or redirecting; Optical components therefor A61B2018/2255 takes precedence
• CPC Class Codes: A61B 2018/2065 Multiwave; Wavelength mixing, e.g. using four or more wavelengths pilot laser A61B2018/2025
• CPC Class Codes: A61B 2018/207 mixing two wavelengths
• CPC Class Codes: A61B 2018/208 with multiple treatment beams not sharing a common path, e.g. non-axial or parallel
• CPC Class Codes: A61B 2018/2205 Characteristics of fibres
• CPC Class Codes: A61B 2018/2244 Features of optical fibre cables, e.g. claddings

Abstract

A multiwavelength laser-based intense light source is described having applications in incision, excision and ablation of soft tissues with minimal collateral tissue damage. The light source combines the output of a plurality of relatively low power laser sources, emitting radiation in the region of the electromagnetic spectrum bounded by approximately 350 nm to 450 nm, where the combined output may be coupled into a single fiber optic energy delivery device: a standard surgical probe. Spectral and spatial beam combining are used to produce an incoherent light source with relatively low average power at any given wavelength, but with high total power and superior M2 beam quality, targeting multiple chromophores in target tissue and tissue breakdown product chromophores for consistently high and target absorption without indiscriminant char interference throughout a surgical procedure.

Claims

1. A process comprising:

combining light beams from a plurality of laser sources into a polychromatic light beam that comprises a plurality of narrow-bandwidth light beams having output wavelengths in the range of 340 nm to 460 nm;

the plurality of laser sources including a first-laser source and a second-laser source, the first-laser source and the second-laser source having output wavelengths which differ by at least 2 nm; and

optically coupling the polychromatic light beam to an interventional or diagnostic-laser-delivery device adapted for directing the polychromatic light beam to a surgical target.

2. The process of claim 1, wherein combining the beams from the plurality of laser sources includes a waveguide optically coupled to a first laser source and a second laser source.

3. The process of claim 2, wherein the first laser source is a continuous wave laser source.

4. The process of claim 1, further comprising directing the polychromatic light beam to a surgical target;

and

vaporizing the surgical target without char formation.

5. The process of claim 4, where in the surgical target is hyperplastic prostate tissue.

6. The process of claim 4, where in the surgical target is soft tissue.

7. The process of claim 1 further comprising:

directing the polychromatic light beam from the delivery device to a surgical target;

contacting the surgical target with the polychromatic light beam, wherein the first-laser source output wavelength corresponds to a first absorption maximum of a surgical chromophore, and the second-laser source output wavelength corresponds to a second absorption maximum of a surgical chromophore.

8. The process of claim 7, wherein the polychromatic light beam vaporizes the surgical target without char formation.

9. The process of claim 7, further comprising a third-laser source having a third-laser source output wavelength;

wherein the polychromatic light beam includes the third-laser source output wavelength which corresponds to a third absorption maximum of a surgical chromophore.

10. The process of claim 7, wherein the delivery device includes an optical fiber;

and wherein the polychromatic light beam is coupled to the optical fiber.

11. The process of claim 7, wherein the surgical target includes a first surgical chromophore and a second surgical chromophore;

and wherein the first output wavelength corresponds to an absorption maximum of the first surgical chromophore, and the second output wavelength corresponds to an absorption maximum of the second surgical chromophore;

wherein the surgical chromophores are, individually, selected from an endogenous chromophore, a chromophore breakdown product, or a chromophore derivative.

12. A process comprising:

combining light beams from a plurality of diode laser sources into a polychromatic light beam;

the plurality of diode laser sources including a first-laser source and a second-laser source, the first-laser source and the second-laser source having output wavelengths which differ by at least 2 nm and are in the range of about 340 nm to about 460 nm;

optically coupling the polychromatic light beam to an interventional or diagnostic-laser-delivery device;

directing the polychromatic light beam from the delivery device to a surgical target;

contacting the surgical target tissue with the polychromatic light beam; and

vaporizing the surgical target tissue.

13. The process of claim 12, wherein each diode laser source has a power output less than about 1 W.

14. The process of claim 12, wherein the first-laser source has an output wavelength which corresponds to an absorption maximum of deoxy-hemoglobin in the range of about 340 nm to about 460 nm;

and the second-laser source has an output wavelength which corresponds to an absorption maximum of oxy-hemoglobin in the range of about 340 nm to about 460 nm.

15. The process of claim 12, wherein the surgical target is selected from soft tissue, prostate tissue, seminal fluid, and a mixture thereof.

16. The process of claim 12, wherein the first laser source has a first output wavelength which corresponds to an absorption maximum of a tissue endogenous chromophore, and the second laser source has a second output wavelength which corresponds to an absorption maximum of a second endogenous chromophore, a chromophore breakdown product, or a chromophore derivative.