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Lipid nanoparticle compositions and methods for mRNA delivery

  • US 10,413,618 B2
  • Filed: 12/26/2018
  • Issued: 09/17/2019
  • Est. Priority Date: 06/08/2011
  • Status: Active Grant
First Claim
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1. A method for delivery of messenger RNA (mRNA) for in vivo production of a protein, comprising administering, to a human, a composition comprising an mRNA that encodes the protein wherein the mRNA is encapsulated within a lipid nanoparticle, wherein the administering of the composition results in expression of the protein encoded by the mRNA that is detectable in serum at least 72 hours after administration, and wherein the lipid nanoparticle comprises one or more PEG-modified lipids.

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