Rotary motor based transdermal injection device

• US 10,413,671 B2
• Filed: 09/12/2018
• Issued: 09/17/2019
• Est. Priority Date: 09/12/2017
• Status: Active Grant

• Current Assignee: Portal Instruments, Inc.
• Original Assignee: Portal Instruments, Inc.
• Inventors: Dyer, Robert J., Tappan, Carl, VanWyk, Eric
• Primary Examiner(s): Price, Nathan R
• Assistant Examiner(s): Snyder, Melissa A
• Application Number:
  US16/129,241
• Publication Number:
  US 20190076602A1
• Time in Patent Office: 370 Days
• CPC Class Codes: A61M 2205/103 rotating
• CPC Class Codes: A61M 2205/13 with means for the detection of operative contact with patient, e.g. lip sensor
• CPC Class Codes: A61M 2205/3327 Measuring
• CPC Class Codes: A61M 2205/3344 Measuring or controlling pressure at the body treatment site
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 5/1452 pressurised by means of pistons
• CPC Class Codes: A61M 5/16877 Adjusting flow; Devices for setting a flow rate
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: A61M 5/3007 with specially designed jet passages at the injector's distal end
• CPC Class Codes: A61M 5/48 having means for varying, regulating, indicating or limiting injection pressure A61M5/142 takes precedence ; monitoring pressure in infusion systems A61M5/16854
• CPC Class Codes: A61M 5/482 Varying injection pressure, e.g. by varying speed of injection

Abstract

An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.

Claims

1. An apparatus for injectate delivery comprising:

a cartridge containing a volume of an injectate and an exit port;

a linear actuator configured for delivery of the injectate from the exit port of the cartridge, the linear actuator including a linkage;

a rotary motor mechanically coupled to the linkage; and

a controller coupled to the rotary motor;

wherein the controller is configured to control a linear motion of the actuator in response to a control signal by controlling an electrical input supplied to the motor in a first interval during which the rotary motor is stationary;

a second interval immediately following the first interval during which the controller accelerates the rotary motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity at least sufficient to pierce human tissue to a subcutaneous depth;

a third interval during which the controller maintains the rotary motor at or above the first speed; and

a fourth interval during which the controller decelerates the rotary motor to a second speed selected to deliver the volume of the injectate at the subcutaneous depth;

wherein the rotary motor provides sufficient power to reach the first speed in not more than three rotations.

2. The apparatus of claim 1 wherein the linear actuator is not more than three rotations from engagement with the rotary motor at a beginning of the second interval.

3. The apparatus of claim 1 wherein the controller is configured to deliver a sequence of injections of the injectate from the volume without reverse movement of the rotary motor.

4. The apparatus of claim 1 wherein the controller is configured to deliver a sequence of injections of the injectate from the volume in close temporal proximity to one another.

5. The apparatus of claim 1 wherein the volume is at least one milliliter.

6. The apparatus of claim 1 wherein the volume is in a range from 0.5 milliliters to 1 milliliter.

7. The apparatus of claim 1 wherein the volume is not greater than about 0.5 milliliters.

8. The apparatus of claim 1 wherein the volume is not greater than about 0.3 milliliters.

9. The apparatus of claim 1 wherein the volume is a therapeutic amount of the injectate.

10. The apparatus of claim 1 wherein the injectate is a biological drug.

11. The apparatus of claim 1 wherein the injectate has a viscosity of at least three centipoise at a temperature between two degrees and twenty degrees Celsius.

12. The apparatus of claim 1 wherein the injectate has a viscosity of about three centipoise to about two hundred centipoise at a temperature between two degrees and twenty degrees Celsius.

13. The apparatus of claim 1 wherein a second velocity of the jet of injectate from the cartridge during the second interval reaches at least two hundred meters per second.

14. The apparatus of claim 1 wherein a duration of the second interval is less than hundred milliseconds.

15. The apparatus of claim 1 wherein a duration of the second interval is less than sixty milliseconds.

16. The apparatus of claim 1 wherein the second interval is less than ten milliseconds.

17. The apparatus of claim 1 wherein the linear actuator is bidirectionally coupled to the rotary motor and the cartridge to permit bidirectional displacement of contents of the cartridge.

18. The apparatus of claim 1 further comprising a plurality of supercapacitors coupled to the rotary motor and configured to provide electrical power to the rotary motor during the second interval, the third interval and the fourth interval.

19. The apparatus of claim 18 wherein the plurality of supercapacitors are configured to charge in parallel and discharge to power the rotary motor in serial.

20. The apparatus of claim 18 wherein the rotary motor and the plurality of supercapacitors are configured to deliver a peak power to the linear actuator of at least two hundred Watts.