Ultrasound tracking of medication delivery by medication injection devices

• US 10,413,676 B1
• Filed: 10/23/2017
• Issued: 09/17/2019
• Est. Priority Date: 10/24/2016
• Status: Active Grant

• Current Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Original Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Inventors: Krasnow, Benjamin David
• Primary Examiner(s): Bosworth, Kami A
• Application Number:
  US15/790,932
• Time in Patent Office: 694 Days
• CPC Class Codes: A61B 5/002 Monitoring the patient using a local or closed circuit, e.g. in a room or building A61B5/0017 takes precedence
• CPC Class Codes: A61B 5/0026 characterised by the transmission medium
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/4848 Monitoring or testing the effects of treatment, e.g. of medication
• CPC Class Codes: A61M 2205/33 Controlling, regulating or measuring
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/332 Force measuring means
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2205/3375 Acoustical, e.g. ultrasonic, measuring means
• CPC Class Codes: A61M 2205/3561 local, e.g. within room or hospital
• CPC Class Codes: A61M 2205/3584 using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: A61M 5/31568 Means keeping track of the total dose administered, e.g. since the cartridge was inserted

Abstract

A medication injection device includes a plunger head having an elastomer housing that fits within a barrel. The plunger head includes an ultrasonic transducer that sends and receives ultrasonic signals in the form of ultrasonic waves, an antenna, a microcontroller that interfaces with the ultrasonic transducer and the antenna, and a power source that powers the microcontroller and the ultrasonic transducer. The ultrasonic transducer, the antenna, the microcontroller, and the power source may be at least partially encapsulated in the elastomer housing. The microcontroller may be programmed to measure echo times of the ultrasonic waves, compare consecutive echo times, and apply a compensation factor. The microcontroller may also be programmed to calculate a volume of medication dispensed from the barrel.

Claims

1. A plunger head, comprising:

an elastomer housing configured to fit within a barrel of a medication injection device;

an ultrasonic transducer configured to send and receive ultrasonic signals as ultrasonic waves;

an antenna;

a microcontroller electrically coupled to the ultrasonic transducer and the antenna; and

a power source electrically coupled to the microcontroller and the ultrasonic transducer and configured to power the microcontroller and the ultrasonic transducer;

wherein the ultrasonic transducer, the antenna, the microcontroller, and the power source are at least partially encapsulated in the elastomer housing;

wherein the microcontroller is programmed with instructions that when executed by the microcontroller cause the plunger head to perform operations including;

measuring echo times of the ultrasonic waves;

comparing consecutive echo times of the ultrasonic waves to determine a change in distance travelled by the plunger head;

assessing whether the change in distance is deemed to be indicative of an error;

applying a compensation factor to the change in distance when the change in distance is deemed to be indicative of the error; and

calculating a volume of medication dispensed from the barrel based on the change in distance of the plunger head, as compensated by the compensation factor when the change in distance is deemed to be indicative of the error.

2. The plunger head of claim 1, wherein assessing whether the change in distance is deemed to be indicative of the error comprises:

identifying when the change in distance is greater than or equal to about one wavelength of the ultrasonic waves.

3. The plunger head of claim 2, wherein the compensation factor is equal to about one wavelength of the ultrasonic waves.

4. The plunger head of claim 1, wherein the microcontroller is programmed with further instructions that when executed by the microcontroller cause the plunder head to perform additional operations comprising:

determining that the change in distance is not indicative of the error when the change in distance is less than one wavelength of the ultrasonic waves.

5. The plunger head of claim 1, wherein the ultrasonic signals have a frequency between about 2 Mhz and about 3 Mhz.

6. The plunger head of claim 1, wherein the microcontroller is programmed with further instructions that when executed by the microcontroller cause the plunger head to perform additional operations comprising:

starting to assess whether the change in distance is deemed to be indicative of the error only after the plunger head reaches a last 20% of a total available travel distance of the plunger head within the barrel.

7. The plunger head of claim 1, wherein the microcontroller is programmed with further instructions that when executed by the microcontroller cause the plunger head to perform additional operations comprising:

transmitting data indicative of the volume of medication dispensed from the barrel to a remote device via the antenna.

8. The plunger head of claim 7, wherein the microcontroller is programmed with further instructions that when executed by the microcontroller cause the plunger head to perform additional operations comprising:

registering a date and time the volume of medication is dispensed; and

transmitting the date and time to the remote device along with the data indicative of the volume of medication dispensed.

9. The plunger head of claim 1, further comprising a temperature sensor configured to measure a temperature of the volume of medication, wherein the microcontroller is programmed with further instructions that when executed by the microcontroller cause the plunger head to perform additional operations comprising:

compensating for changes in the temperature of the volume of medication when calculating the volume of medication dispensed.

10. The plunger head of claim 1, wherein the medication injection device is at least one of a disposable syringe, an auto-injector, or insulin pen.