Method for low latency automated closed-loop synchronization of neurostimulation interventions to neurophysiological activity

• US 10,413,724 B2
• Filed: 04/06/2018
• Issued: 09/17/2019
• Est. Priority Date: 10/23/2015
• Status: Active Grant

• Current Assignee: HRL Laboratories LLC (The Boeing Co.)
• Original Assignee: HRL Laboratories LLC (The Boeing Co.)
• Inventors: Choe, Jaehoon, Pilly, Praveen K.
• Primary Examiner(s): Holmes, Rex R
• Application Number:
  US15/947,733
• Publication Number:
  US 20180221661A1
• Time in Patent Office: 529 Days
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/374 Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves
• CPC Class Codes: A61B 5/4806 Sleep evaluation A61B5/4821 takes precedence; devices for inducing sleep A61M21/02
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61B 5/6814 Head
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence
• CPC Class Codes: A61M 2021/0055 with electric or electro-magnetic fields
• CPC Class Codes: A61M 2021/0072 with application of electrical currents
• CPC Class Codes: A61M 21/00 Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
• CPC Class Codes: A61M 21/02 for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia for massage A61H; electrotherapy A61N, e.g. applying alternating or intermittent electric currents for producing anaesthesia A61N1/36021
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2230/005 Parameter used as control input for the apparatus
• CPC Class Codes: A61M 2230/10 Electroencephalographic signals
• CPC Class Codes: A61N 1/025 Digital circuitry features of electrotherapy devices, e.g. memory, clocks, processors
• CPC Class Codes: A61N 1/0456 Specially adapted for transcutaneous electrical nerve stimulation [TENS]
• CPC Class Codes: A61N 1/0476 Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
• CPC Class Codes: A61N 1/36025 : for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36031 : using physiological parameters for adjustment
• CPC Class Codes: G16H 20/30 : relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• CPC Class Codes: G16H 50/30 : for calculating health indices; for individual health risk assessment

Abstract

Described is a system for synchronization of neurostimulation interventions. The system continuously monitors incoming neurophysiological signals. Latencies present in the monitoring of the incoming neurophysiological signals are measured. Based on the measured latencies, the timing of targeted neurostimulation interventions is determined, resulting in a neurostimulation intervention protocol. The neurostimulation intervention protocol is adjusted in real time for administration of neurostimulation during temporal regions of interest. The system then triggers administration of the neurostimulation during the temporal regions of interest.

Claims

1. A system for synchronization of neurostimulation interventions, the system comprising:

one or more processors and a non-transitory computer-readable medium having executable instructions encoded thereon such that when executed, the one or more processors perform operations of;

continuously monitoring incoming neurophysiological signals;

measuring latencies present in the monitoring of the incoming neurophysiological signals;

based on the measured latencies, determining timing of targeted neurostimulation interventions, resulting in a neurostimulation intervention protocol;

adjusting the neurostimulation intervention protocol in real time for administration of neurostimulation during temporal regions of interest;

replicating properties of the incoming neurophysiological signals at the time of neurostimulation; and

administering the neurostimulation during the temporal regions of interest.

2. The system as set forth in claim 1, wherein the one or more processors further perform operations of classifying the incoming neurophysiological signals and adapting the administered neurostimulation according to the classified incoming neurophysiological signals.

3. The system as set forth in claim 1, wherein the one or more processors further perform an operation of verifying that the administered neurostimulation replicates the properties of the incoming neurophysiological signals.

4. The system as set forth in claim 1, wherein the one or more processors further perform an operation of calibrating the triggering of the administration of the neurostimulation to a set of predetermined neurophysiological signals.

5. The system as set forth in claim 1, wherein the one or more processors further perform an operation of determining potential time points of neurostimulation during which the administered neurostimulation matches predicted neurophysiological signals for slow-wave sleep augmentation.

6. A computer implemented method for synchronization of neurostimulation interventions, the method comprising an act of:

causing one or more processers to execute instructions encoded on a non-transitory computer-readable medium, such that upon execution, the one or more processors perform operations of;

continuously monitoring incoming neurophysiological signals;

measuring latencies present in the monitoring of the incoming neurophysiological signals;

based on the measured latencies, determining timing of targeted neurostimulation interventions, resulting in a neurostimulation intervention protocol;

adjusting the neurostimulation intervention protocol in real time for administration of neurostimulation during temporal regions of interest;

replicating properties of the incoming neurophysiological signals at the time of neurostimulation; and

administering the neurostimulation during the temporal regions of interest.

7. The method as set forth in claim 6, wherein the one or more processors further perform an operation of classifying the incoming neurophysiological signals and adapting the administered neurostimulation according to the classified incoming neurophysiological signals.

8. The method as set forth in claim 6, wherein the one or more processors further perform an operation of verifying that the administered neurostimulation replicates the properties of the incoming neurophysiological signals.

9. The method as set forth in claim 6, wherein the one or more processors further perform an operation of calibrating the triggering of the administration of the neurostimulation to a set of predetermined neurophysiological signals.

10. The method as set forth in claim 6, wherein the one or more processors further perform an operation of determining potential time points of neurostimulation during which the administered neurostimulation matches predicted neurophysiological signals for slow-wave sleep augmentation.

11. A computer program product for synchronization of neurostimulation interventions, the computer program product comprising:

computer-readable instructions stored on a non-transitory computer-readable medium that are executable by a computer having one or more processors for causing the processor to perform operations of;

continuously monitoring incoming neurophysiological signals;

measuring latencies present in the monitoring of the incoming neurophysiological signals;

based on the measured latencies, determining timing of targeted neurostimulation interventions, resulting in a neurostimulation intervention protocol;

adjusting the neurostimulation intervention protocol in real time for administration of neurostimulation during temporal regions of interest;

replicating properties of the incoming neurophysiological signals at the time of neurostimulation; and

administering the neurostimulation during the temporal regions of interest.

12. The computer program product as set forth in claim 11, further comprising instructions for causing the one or more processors to further perform an operation of classifying the incoming neurophysiological signals and adapting the administered neurostimulation according to the classified incoming neurophysiological signals.

13. The computer program product as set forth in claim 11, further comprising instructions for causing the one or more processors to further perform an operation of verifying that the administered neurostimulation replicates the properties of the incoming neurophysiological signals.

14. The computer program product as set forth in claim 11, further comprising instructions for causing the one or more processors to further perform an operation of calibrating the triggering of the administration of the neurostimulation to a set of predetermined neurophysiological signals.

15. The computer program product as set forth in claim 11, further comprising instructions for causing the one or more processors to further perform an operation of determining potential time points of neurostimulation during which the administered neurostimulation matches predicted neurophysiological signals for slow-wave sleep augmentation.