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Method for low latency automated closed-loop synchronization of neurostimulation interventions to neurophysiological activity

  • US 10,413,724 B2
  • Filed: 04/06/2018
  • Issued: 09/17/2019
  • Est. Priority Date: 10/23/2015
  • Status: Active Grant
First Claim
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1. A system for synchronization of neurostimulation interventions, the system comprising:

  • one or more processors and a non-transitory computer-readable medium having executable instructions encoded thereon such that when executed, the one or more processors perform operations of;

    continuously monitoring incoming neurophysiological signals;

    measuring latencies present in the monitoring of the incoming neurophysiological signals;

    based on the measured latencies, determining timing of targeted neurostimulation interventions, resulting in a neurostimulation intervention protocol;

    adjusting the neurostimulation intervention protocol in real time for administration of neurostimulation during temporal regions of interest;

    replicating properties of the incoming neurophysiological signals at the time of neurostimulation; and

    administering the neurostimulation during the temporal regions of interest.

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