Methods and devices for multi-stage ventricular therapy

• US 10,413,741 B2
• Filed: 09/19/2018
• Issued: 09/17/2019
• Est. Priority Date: 12/11/2007
• Status: Active Grant

• Current Assignee: Washington University In St Louis
• Original Assignee: Washington University In St Louis
• Inventors: Efimov, Igor R., Li, Wenwen, Janardhan, Ajit H.
• Primary Examiner(s): Morales, Jon Eric C
• Application Number:
  US16/135,477
• Publication Number:
  US 20190015670A1
• Time in Patent Office: 363 Days
• Field of Search: 607 5
• CPC Class Codes: A61N 1/3624 occurring in the atrium, i.e. atrial tachycardia
• CPC Class Codes: A61N 1/3906 characterised by the form of the shockwave
• CPC Class Codes: A61N 1/3918 characterised by shock pathway, e.g. by electrode configuration
• CPC Class Codes: A61N 1/395 for treating atrial fibrillation
• CPC Class Codes: A61N 1/3956 Implantable devices for applying electric shocks to the heart, e.g. for cardioversion
• CPC Class Codes: A61N 1/3981 High voltage charging circuitry

Abstract

Methods and apparatus for a three-stage ventricular cardioversion and defibrillation therapy that treats ventricular tachycardia and fibrillation at low energy levels. An implantable therapy generator adapted to generate and selectively deliver a three-stage ventricular therapy and at least two leads operably each having at least one electrode adapted to be positioned proximate the ventricle of the patient. The device is programmed to deliver a three-stage therapy via both a far-field configuration and a near-field configuration of the electrodes upon detection of a ventricular arrhythmia. The three-stage therapy includes a first stage for unpinning of one or more singularities associated with the ventricular arrhythmia, a second stage for anti-repinning of the one or more singularities, both of which are delivered via the far-field configuration of the electrodes, and a third stage for extinguishing of the one or more singularities associated delivered via the near-field configuration of the electrodes.

Claims

1. An arrhythmia treatment device comprising:

a plurality of electrodes, wherein the plurality of electrodes includes at least one far-field electrode configured to deliver far-field pulses, and at least one near-field electrode configured to deliver near-field pulses;

sensing circuitry configured to detect one or more cardiac signals;

detection circuitry operably coupled to the sensing circuitry, wherein the detection circuitry is configured to determine an atrial cycle length based on the one or more cardiac signals and to determine existence of atrial arrhythmia based at least in part on the atrial cycle length; and

control circuitry operably coupled to the detection circuitry and to the plurality of electrodes, wherein the control circuitry is configured to initiate delivery of a plurality of pulses when the existence of atrial arrhythmia is determined by the detection circuitry, wherein the plurality of pulses initiated includes;

a first set of biphasic pulses of 2 volts to 400 volts each configured to be delivered via the at least one far-field electrode; and

a second set of monophasic pulses of 0.5 volts to 20 volts configured to be delivered via the at least one far-field electrode;

wherein at least one of the first set of pulses or the second set of pulses is delivered without confirmation of conversion of the atrial arrhythmia.

2. The device of claim 1, further comprising an implantable therapy generator, wherein the implantable therapy generator is configured to act as one of the plurality of electrodes.

3. The device of claim 1, wherein delivery of the second set of pulses occurs 100 to 400 milliseconds after cessation of the first set of pulses.

4. The device of claim 1, wherein the first set of pulses includes at least 2 and less than 10 pulses, and wherein the second set of pulses includes at least 5 and less than 10 pulses.

5. The device of claim 1, wherein the first set of pulses has a pulse duration of less than 10 milliseconds.

6. The device of claim 1, wherein the first set of pulses has a pulse coupling interval of between 20 to 50 milliseconds.

7. The device of claim 1, wherein the first set of pulses has a total duration of less than twice the atrial cycle length.

8. The device of claim 1, wherein the second set of pulses has a pulse duration of more than 5 and less than 20 milliseconds.

9. The device of claim 1, wherein the second set of pulses has a pulse coupling interval of between 70% to 90% of the atrial cycle length.

10. The device of claim 1, wherein the plurality of pulses initiated further includes a third set of pulses having a pulse duration of more than 0.2 and less than 5 milliseconds.

11. The device of claim 1, wherein at least one of the plurality of electrodes is both a far-field electrode and a near-field electrode.

12. The device of claim 1, further comprising a plurality of capacitors, wherein a first capacitor of the plurality of capacitors is configured to discharge energy for delivery of the first set of pulses, and a second capacitor of the plurality of capacitors is configured to discharge energy for delivery of the second set of pulses, and wherein the first capacitor and the second capacitor are configured to recharge at different times.

13. An arrhythmia treatment device comprising:

a plurality of electrodes, wherein the plurality of electrodes includes at least one far-field electrode configured to deliver far-field pulses, and at least one near-field electrode configured to deliver near-field pulses;

an implantable therapy generator;

sensing circuitry configured to detect one or more cardiac signals;

detection circuitry operably coupled to the sensing circuitry, wherein the detection circuitry is configured to determine existence of atrial arrhythmia based at least in part on the one or more cardiac signals;

control circuitry operably coupled to the detection circuitry and to the plurality of electrodes, wherein the control circuitry is configured to initiate delivery of a plurality of pulses when the existence of atrial arrhythmia is determined by the detection circuitry, wherein the plurality of pulses initiated includes;

a first set of pulses including at least 2 and less than 10 pulses of 2 volts to 400 volts each configured to be delivered via the at least one far-field electrode; and

a second set of pulses including at least 5 and less than 10 pulses of 0.5 volts to 20 volts configured to be delivered via the at least one far-field electrode; and

a plurality of capacitors, wherein a first capacitor of the plurality of capacitors is configured to discharge energy for delivery of the first set of pulses, and a second capacitor of the plurality of capacitors is configured to discharge energy for delivery of the second set of pulses.

14. The device of claim 13, wherein delivery of the second set of pulses occurs 100 to 400 milliseconds after cessation of the first set of pulses, and wherein at least one of the first set of pulses or the second set of pulses is delivered without confirmation of conversion of the atrial arrhythmia.

15. The device of claim 13, wherein the implantable therapy generator is configured to act as one of the plurality of electrodes.

16. The device of claim 13, wherein the first set of pulses is biphasic, and the second set of pulses is monophasic.

17. An arrhythmia treatment device comprising:

a plurality of electrodes, wherein the plurality of electrodes includes at least one far-field electrode configured to deliver far-field pulses, and at least one near-field electrode configured to deliver near-field pulses;

an implantable therapy generator;

sensing circuitry configured to detect one or more cardiac signals;

detection circuitry operably coupled to the sensing circuitry, wherein the detection circuitry is configured to determine an atrial cycle length based on the one or more cardiac signals and to determine existence of atrial arrhythmia based at least in part on the atrial cycle length;

control circuitry operably coupled to the detection circuitry and to the plurality of electrodes, wherein the control circuitry is configured to initiate delivery of a plurality of pulses when the existence of atrial arrhythmia is determined by the detection circuitry, wherein the plurality of pulses initiated includes;

a first set of biphasic pulses 2 volts to 400 volts each configured to be delivered via the at least one far-field electrode; and

a second set of monophasic pulses of 0.5 volts to 20 volts configured to be delivered via the at least one far-field electrode; and

a plurality of capacitors, wherein a first capacitor of the plurality of capacitors is configured to discharge energy for delivery of the first set of pulses, and a second capacitor of the plurality of capacitors is configured to discharge energy for delivery of the second set of pulses, and wherein the first capacitor and the second capacitor are configured to recharge at different times;

wherein the control circuitry is configured to initiate delivery of the second set of pulses 100 to 400 milliseconds after cessation of the first set of pulses.

18. The device of claim 17, wherein the first set of pulses includes at least 2 and less than 10 pulses, and the second set of pulses at least 5 and less than 10 pulses.

19. The device of claim 17, wherein at least one of the first set of pulses or the second set of pulses is delivered without confirmation of conversion of the atrial arrhythmia.

20. The device of claim 17, wherein the implantable therapy generator is configured to act as one of the plurality of electrodes.