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Devices, systems and methods for linearization of polymers

  • US 10,413,903 B2
  • Filed: 11/01/2016
  • Issued: 09/17/2019
  • Est. Priority Date: 05/08/2014
  • Status: Active Grant
First Claim
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1. A system for sequencing a biopolymer, comprising:

  • a nanochannel having a detection region for detecting said biopolymer or a portion thereof upon flow of said biopolymer through said detection region; and

    a first entropic trapping component and a second entropic trapping component disposed in or adjacent to said nanochannel, wherein (i) said first entropic trapping component is operable to linearize said biopolymer upon flow of said biopolymer through said first entropic trapping component and towards a first side of said detection region, and (ii) said second entropic trapping component is operable to linearize said biopolymer upon flow of said biopolymer through said second entropic trapping component and towards a second side of said detection region, which first side is different from said second side,wherein said first entropic trapping component is in said nanochannel, and wherein said first entropic trapping component includes an increase in cross-section of said nanochannel followed by a decrease in cross-section of said nanochannel towards said detection region.

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