Nanoparticles for mitochondrial trafficking of agents
First Claim
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1. A nanoparticle, comprising:
- a hydrophobic nanoparticle core;
a hydrophilic layer surrounding the core; and
a mitochondria targeting moiety tethered to the core,wherein the nanoparticle has a diameter of from about 10 nanometers to about 200 nanometers or less and has a zeta potential of about 0 mV or greater.
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Abstract
Nanoparticles include a core, a hydrophilic layer around the core, and one or more mitochondrial targeting moieties, and may optionally include one or more contrast agents or one or more therapeutic agents. For effective mitochondrial targeting the nanoparticles have a diameter of about 200 nm or less or have a zeta potential of about 0 mV or more.
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Citations
24 Claims
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1. A nanoparticle, comprising:
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a hydrophobic nanoparticle core; a hydrophilic layer surrounding the core; and a mitochondria targeting moiety tethered to the core, wherein the nanoparticle has a diameter of from about 10 nanometers to about 200 nanometers or less and has a zeta potential of about 0 mV or greater. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification