Device and method for generating calibration factors for use in determining biological indicator levels in tissue

• US 10,420,491 B2
• Filed: 05/26/2016
• Issued: 09/24/2019
• Est. Priority Date: 05/26/2015
• Status: Active Grant

• Current Assignee: Happy Health, Inc.
• Original Assignee: LVL Technologies, Inc.
• Inventors: Rajan, Nithin O., Freckleton, Dustin M., Xavier da Silveira, Paulo E., Olson, Byron
• Primary Examiner(s): Green, Yara B
• Application Number:
  US15/576,671
• Publication Number:
  US 20180132767A1
• Time in Patent Office: 1,216 Days
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/02438 with portable devices, e.g. worn by the patient
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14535 for measuring haematocrit
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/4875 Hydration status, fluid retention of the body
• CPC Class Codes: A61B 5/6828 Leg

Abstract

Optical-electronic device configured to generate a calibration factor for use in determining optical density. The device includes at least one emitter configured to emit light, a detector configured to receive light and transmit data representative of the received light and a processor coupled to the at least one emitter and the detector. The device further includes a non-transitory storage medium coupled to the processor and configured to store instruction to cause the device to perform the calibration method. Additionally, a calibration container includes a main body, upper lid, and a lower lid. The main body is configured to receive the device and an object having known optical properties.

Claims

1. A device configured to generate at least one calibration factor for use in determining optical density, the device comprising:

a plurality of emitters, each having at least one light source, each of the emitters configured to emit light;

a detector configured to receive light and transmit data representative of the received light;

at least two of the plurality of emitters are spaced at different distances from the detector;

a processor coupled to the at least one emitter and the detector;

a non-transitory storage medium coupled to the processor and configured to store instructions to cause the device to repeat the following for each of the light sources;

emit light from one of the light sources of one of the emitters at a predetermined current towards an object that has a known optical density;

detect, at the detector, a portion of the emitted light corresponding to the predetermined current;

calculate, at the processor, a corresponding calibration factor based on the detected portion of emitted light through the object;

store the corresponding calibration factor in the non-transitory storage medium.

2. The device as recited in claim 1, further comprising instructions to cause, repeatedly for each light source and each of a plurality of predetermined currents, the device to:

emit light from one of the at least one light source of the at least one emitter at one of the plurality of predetermined currents towards the object;

detect, at the detector, a portion of the emitted light corresponding to the predetermined current;

calculate, at the processor, a corresponding calibration factor based on the detected portion of emitted light through the object;

store the corresponding calibration factor in the non-transitory storage medium.

3. The device as recited in claim 1, wherein the at least one emitter comprises a plurality of emitters and each of the plurality of emitters having a plurality of light sources, and further comprising instructions to cause the device to:

emit light, towards the object, from one of the plurality of light sources of one of the emitters at one of a plurality of predetermined currents;

detect, at the detector, a portion of the emitted light corresponding to the one of a the plurality of predetermined currents;

calculate, at the processor, a corresponding calibration factor based on the detected portion of emitted light through the object;

store the corresponding calibration factor in the non-transitory storage medium.

4. The device as recited in claim 1, wherein the predetermined current comprises a plurality of currents and each of the steps are performed for each of the plurality of currents.

5. The device in claim 4, further comprising instructions stored on the non-transitory storage medium to cause the device to:

confirm that at least one calibration factor is stored for each light source at the plurality of currents.

6. The device as recited in claim 5, wherein the plurality of predetermined currents are based on a corresponding plurality of predetermined currents and the calculation of the corresponding calibration factor is derived using the formula:

C_ijm=10^ODjm/D_ijm, where i is an index tracking a predetermined current value, j is an index tracking a light source, m is an index tracking a spacing between the light source and detector, OD is the optical density, and D is measured light data.

7. The device as recited in claim 5, wherein the non-transitory storage medium further comprises instructions, upon receiving a measurement command, to:

emitting, iteratively, light from one of a plurality of light sources at one of a plurality of predetermined currents towards the object;

detecting, at a detector, a portion of the emitted light corresponding to a respective one of the light sources and predetermined currents;

determining an optical density of the object based on the calibration factors.

8. The device as recited in claim 1, wherein the corresponding calibration factor is transmitted via a network interface component to a server.

9. The device as recited in claim 1, wherein the corresponding calibration factor is transmitted via a network interface component to an external electronic device.

10. The device as recited in claim 1, wherein the object is made of a material that is designed to mimic a biological tissue.

11. The device as recited in claim 1, wherein the at least one emitter comprises at least two emitters that are spaced apart from each other and from the detector.

12. The device as recited in claim 11, wherein one of the emitters is further away from the detector than the other.

13. The device as recited in claim 12, wherein each of the emitters are arranged along a ray extending from the detector.

14. The device as recited in claim 12, wherein each of the emitters are located on a same side of the detector.

15. The device as recited in claim 11, wherein each of the two emitters comprise a plurality of light sources.

16. The device as recited in claim 15, wherein each of the two emitters comprise four light sources.

17. The device as recited in claim 15, wherein each of the plurality of light sources within a given one of the at least two emitters has a different peak wavelength of emission.

18. A system including an electronic device and a hardware server, the system configured to generate at least one calibration factor for use in determining optical density and comprising:

a plurality of emitters, each having at least one light source, each of the emitters configured to emit light;

a detector configured to receive light and transmit data representative of the received light;

at least two of the plurality of emitters are spaced at different distances from the detector;

a processor coupled to the at least one emitter and the detector;

a non-transitory storage medium coupled to the processor and configured to store instructions to cause the device to repeat the following for each of the light sources;

emit light from one of the light sources of one of the emitters at a predetermined current towards an object that has a known optical density;

detect, at the detector, a portion of the emitted light corresponding to the predetermined current;

calculate, at the processor, a corresponding calibration factor based on the detected portion of emitted light through the object;

store the corresponding calibration factor in the non-transitory storage medium.