Compounds for inducing anti-tumor immunity and methods thereof
First Claim
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1. A method for enhancing or inducing an anti-tumor response in a subject, the method comprising:
- administering to the subject an effective amount of a direct inhibitor of IRE1α
for enhancing or inducing an anti-tumor immune response in the subject, wherein the effective amount of the direct inhibitor of IRE1α
increases antigen presentation in antigen presenting cells, wherein the tumor is a solid tumor, wherein the solid tumor is from an ovarian cancer, epithelial cancer, germ cell cancer, or a stromal tumor, and wherein the direct inhibitor of IRE1α
is a small molecule inhibitor of IRE-1α
.
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Abstract
Described herein is a previously unknown function of XBP1 in controlling anti-tumor immunity. It is shown that inhibiting XBP1 in tumor-associated dendritic cells inhibits tumor growth and induces protective anti-tumor immune responses.
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12 Claims
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1. A method for enhancing or inducing an anti-tumor response in a subject, the method comprising:
administering to the subject an effective amount of a direct inhibitor of IRE1α
for enhancing or inducing an anti-tumor immune response in the subject, wherein the effective amount of the direct inhibitor of IRE1α
increases antigen presentation in antigen presenting cells, wherein the tumor is a solid tumor, wherein the solid tumor is from an ovarian cancer, epithelial cancer, germ cell cancer, or a stromal tumor, and wherein the direct inhibitor of IRE1α
is a small molecule inhibitor of IRE-1α
.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
Specification