Oligomers and oligomer conjugates
First Claim
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1. An oligomer conjugate comprising:
- a) at least a first oligomer that is 10 to 20 nucleotides in length and is perfectly complementary to a sequence from positions 1530 to 1598 of SEQ ID NO;
3; and
b) a carrier component comprising an asialoglycoprotein receptor (ASGP-R) targeting moiety.
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Abstract
The present invention relates to an oligomer conjugate for use in the treatment of a viral disorder. The oligomer conjugate comprises: a) an oligomer capable of modulating a target sequence in HBx and/or HBsAg of Hepatitis B Virus (HBV) to treat said viral disorder; and b) a carrier component capable of delivering the oligomer to the liver which is linked, preferably conjugated, to the oligomer.
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Citations
19 Claims
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1. An oligomer conjugate comprising:
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a) at least a first oligomer that is 10 to 20 nucleotides in length and is perfectly complementary to a sequence from positions 1530 to 1598 of SEQ ID NO;
3; andb) a carrier component comprising an asialoglycoprotein receptor (ASGP-R) targeting moiety. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification