Systems and methods for sensing intraocular pressure

• US 10,426,341 B2
• Filed: 09/28/2015
• Issued: 10/01/2019
• Est. Priority Date: 12/16/2011
• Status: Active Grant

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology
• Inventors: Choo, Hyuck, Sretavan, David
• Primary Examiner(s): McCrosky, David J.
• Application Number:
  US14/868,219
• Publication Number:
  US 20160015266A1
• Time in Patent Office: 1,464 Days
• CPC Class Codes: A61B 3/16 for measuring intraocular pressure, e.g. tonometers
• CPC Class Codes: B82Y 15/00 Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• CPC Class Codes: G01L 1/247 using distributed sensing elements, e.g. microcapsules along a single optical fibre G01L1/242
• CPC Class Codes: G01L 9/0077 for measuring reflected light

Abstract

Systems and methods of sensing intraocular pressure are described. An example miniaturized intraocular pressure (IOP) monitoring system is provided using a nanophotonics-based implantable IOP sensor with remote optical readout that can be adapted for both patient and research use. A handheld detector optically excites the pressure-sensitive nanophotonic structure of the IOP-sensing implant placed in the anterior chamber and detects the reflected light, whose optical signature changes as a function of IOP. Optical detection eliminates the need for large, complex LC structures and simplifies sensor design. The use of nanophotonic components improves the sensor'"'"'s resolution and sensitivity, increases optical readout distance, and reduces its size by a factor of 10-30 over previous implants. Its small size and convenient optical readout allows frequent and accurate self-tracking of IOP by patients in home settings.

Claims

1. A system for sensing biological pressure, comprising:

an implantable device comprising a first membrane structure, a second membrane structure, and a plurality of nanophotonic components adapted to reflect light, wherein the first and second membrane structures are separated by a gap and the first membrane structure is movable with respect to the second membrane structure in response to a change in ambient pressure such that the implantable device has a resonance wavelength that shifts as a size of the gap changes; and

a reader unit adapted to transmit optical light to the implantable device and detect the resonance wavelength of the implantable device based on light reflected from the implantable device.

2. The system of claim 1, wherein the reader unit is adapted to detect the resonance wavelength based on a shift in the resonance wavelength of light reflected from the implantable device.

3. The system of claim 2, wherein the reader unit is adapted to determine the biological pressure based on the detected resonance wavelength of the implantable device.

4. The system of claim 1, wherein the implantable device is adapted for implantation into an eye, and wherein the biological pressure is an intraocular pressure.

5. The system of claim 1, wherein the first and second membrane structures are both deformable in response to the change in ambient pressure.

6. The system of claim 1, wherein the first and second membrane structures are separated by one or more mechanical flexures.

7. The system of claim 1, wherein the first and second membrane structures are rigid.

8. The system of claim 1, wherein the nanophotonic components are nanoparticles.

9. The system of claim 1, wherein the nanophotonic components are embedded in the first and second membrane structures.

10. The system of claim 1, wherein the implantable device is a first implantable device, the system further comprising a plurality of additional implantable devices, each additional implantable device having the same structure as the first implantable device.

11. The system of claim 10, wherein each implantable device is coupled to another implantable device.

12. An apparatus for sensing biological pressure, comprising:

an implantable device comprising a first membrane structure, a second membrane structure, and a plurality of nanophotonic components adapted to reflect light,

wherein the first and second membrane structures are separated by a gap and the first membrane structure is movable with respect to the second membrane structure in response to a change in ambient pressure such that the implantable device has a resonance wavelength that shifts as a size of the gap changes, the resonance wavelength being detectable based on light reflected by the implantable device.

13. The apparatus of claim 12, wherein the first and second membrane structures are separated by one or more mechanical flexures.

14. The apparatus of claim 12, wherein the first and second membrane structures are rigid.

15. The apparatus of claim 12, wherein the nanophotonic components are nanoparticles.

16. The apparatus of claim 12, wherein the nanophotonic components are embedded in the first and second membrane structures.

17. The apparatus of claim 12, wherein the implantable device is a first implantable device, the apparatus further comprising a plurality of additional implantable devices, each additional implantable device having the same structure as the first implantable device.

18. The apparatus of claim 17, wherein each implantable device is coupled to another implantable device.

19. The apparatus of claim 12, further comprising a reader unit adapted to detect the resonance wavelength of the implantable device.

20. The apparatus of claim 19, wherein the reader unit is adapted to detect the resonance wavelength based on a shift in the resonance wavelength of light reflected by the implantable device.

21. The apparatus of claim 20, wherein the reader unit is adapted to determine the biological pressure based on the detected resonance wavelength of the implantable device.

22. The apparatus of claim 12, further comprising a reader unit adapted to detect the resonance wavelength of the implantable device, the reader unit adapted to transmit a plurality of wavelengths to the implantable device, and detect the resonance wavelength based on a reflected plurality of wavelengths of light reflected by the implantable device.

23. The apparatus of claim 22, wherein the reader unit is adapted to determine the biological pressure based on the detected resonance wavelength of the implantable device.

24. The apparatus of claim 12, wherein the implantable device is adapted for implantation into an eye, and wherein the biological pressure is an intraocular pressure.

25. The apparatus of claim 12, wherein the first and second membrane structures are both deformable in response to the change in ambient pressure.