Muting glucose sensor oxygen response and reducing electrode edge growth with pulsed current plating
First Claim
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1. An analyte sensor apparatus comprising:
- a base substrate comprising a well;
a platinum composition disposed in the well, wherein;
the platinum composition is disposed in the well as a layer of electrodeposited platinum black comprising a central planar region having a first thickness and an edge region having a second thickness that surrounds the central planar region;
the first thickness is different from the second thickness;
the average thickness of the platinum black layer in the edge region is less than 2×
the average thickness of the platinum black layer in the central planar region;
the central planar region and the edge region comprise platinum dendrites; and
the layer of electrodeposited platinum black forms an electroactive surface of a working electrode;
an analyte sensing layer disposed over the working electrode, wherein the analyte sensing layer detectably alters the electrical current at the working electrode in the presence of an analyte; and
an analyte modulating layer disposed over the analyte sensing layer, wherein the analyte modulating layer modulates the diffusion of analyte therethrough.
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Abstract
The invention disclosed herein includes amperometric glucose sensors having electrodes formed from processes that electrodeposit platinum black in a manner that produces relatively smooth three dimensional metal architectures, ones that contribute to sensor reliability and stability. Embodiments of the invention provide analyte sensors having such uniform electrode architectures as well as methods for making and using these sensor electrodes. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.
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15 Claims
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1. An analyte sensor apparatus comprising:
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a base substrate comprising a well; a platinum composition disposed in the well, wherein; the platinum composition is disposed in the well as a layer of electrodeposited platinum black comprising a central planar region having a first thickness and an edge region having a second thickness that surrounds the central planar region; the first thickness is different from the second thickness; the average thickness of the platinum black layer in the edge region is less than 2×
the average thickness of the platinum black layer in the central planar region;the central planar region and the edge region comprise platinum dendrites; and the layer of electrodeposited platinum black forms an electroactive surface of a working electrode; an analyte sensing layer disposed over the working electrode, wherein the analyte sensing layer detectably alters the electrical current at the working electrode in the presence of an analyte; and an analyte modulating layer disposed over the analyte sensing layer, wherein the analyte modulating layer modulates the diffusion of analyte therethrough. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 15)
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11. A sensor electrode configuration comprising:
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a base substrate comprising a well; and a platinum composition disposed in the well, wherein; the platinum composition is disposed in the well as a layer of electrodeposited platinum black comprising a central planar region having a first thickness and an edge region having a second thickness that surrounds the central planar region; the average thickness of the platinum black layer in the edge region is less than 2×
the average thickness of the platinum black layer in the central planar region;the first thickness is different from the second thickness; the central planar region and the edge region comprise platinum dendrites; and the layer of electrodeposited platinum black forms an electroactive surface of the electrode.
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13. An amperometric glucose sensor apparatus comprising:
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a base substrate comprising a well; a platinum composition disposed in the well, wherein; the platinum composition is disposed in the well as a layer of electrodeposited platinum black comprising a central planar region having a first thickness and an edge region having a second thickness that surrounds the central planar region; the first thickness is different from the second thickness the average thickness of the platinum black layer in the edge region is less than 2×
the average thickness of the platinum black layer in the central planar region;the central planar region and the edge region comprise platinum dendrites; and the layer of electrodeposited platinum black forms an electroactive surface of a working electrode; an analyte sensing layer disposed over the working electrode, wherein the analyte sensing layer detectably alters the electrical current at the working electrode in the presence of an analyte; an analyte modulating layer disposed over the analyte sensing layer, wherein the analyte modulating layer modulates the diffusion of analyte therethrough; and a processor that assesses signal data from the working electrode wherein; the amperometric glucose sensor apparatus generates a first signal in a solution comprising 100 mg/dL glucose and 5% oxygen; and
a second signal in a solution comprising 100 mg/dL glucose and 0.1% oxygen;and the first signal and the second signal differ by less than 10%. - View Dependent Claims (14)
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Specification